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Isoforms Recommended:	CDK1

Results for "

Cdk-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (189) AAK1 (2) Akt (6) Anaplastic lymphoma kinase (ALK) (1) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (71) Aryl Hydrocarbon Receptor (2) ATM/ATR (2) Aurora Kinase (7) Autophagy (10) Bacterial (1) Bcl-2 Family (7) c-Myc (3) Casein Kinase (1) Caspase (8) CFTR (1) COX (1) Cyclin G-associated Kinase (GAK) (2) DNA/RNA Synthesis (2) Drug Derivative (2) DYRK (1) Endogenous Metabolite (1) Ephrin Receptor (1) ERK (3) FGFR (3) GSK-3 (29) HBV (2) HCV (1) HDAC (1) Histone Demethylase (1) HIV (3) HSP (1) HSV (1) IAP (1) Insulin Receptor (1) Interleukin Related (1) IRAK (1) Isotope-Labeled Compounds (2) Itk (1) JAK (2) JNK (2) Ligands for Target Protein for PROTAC (4) LIM Kinase (LIMK) (1) Lipoxygenase (1) MAP3K (1) MAP4K (1) MDM-2/p53 (1) MEK (2) MELK (1) Microtubule/Tubulin (2) MMP (1) Molecular Glues (4) mTOR (3) Necroptosis (1) NEKs (2) NF-κB (3) Orthopoxvirus (2) p38 MAPK (2) PAK (1) PANoptosis (1) PARP (1) PERK (1) Phosphatase (2) PI3K (7) PKC (3) Polo-like Kinase (PLK) (3) PROTACs (7) Raf (2) Reactive Oxygen Species (ROS) (3) Reference Standards (20) Reverse Transcriptase (1) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (4) SnRK (1) SphK (1) Src (1) STAT (1) Tie (1) TNF Receptor (1) ULK (1) VEGFR (5) Wee1 (6) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (195) Cardiovascular Disease (1) Infection (5) Inflammation/Immunology (9) Metabolic Disease (7) Neurological Disease (12)
Click Chemistry:	Alkynes (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Phospholipids (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (4)

209

Inhibitors & Agonists

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Targets Recommended: CDK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12529

Ro-3306 65+ Cited Publications	CDK Apoptosis	Cancer
Ro-3306 is a potent and selective inhibitor of *CDK1, with K_is of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin* B1 and CDK2/cyclin E, respectively.

HY-10005

Flavopiridol 50+ Cited Publications HMR-1275; Alvocidib; L86-8275	CDK Autophagy HIV Apoptosis	Cancer
Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of *CDKs, inhibiting CDK1, CDK2, CDK4 with IC₅₀*s of 30, 170, 100 nM, respectively.

HY-10492

Dinaciclib 50+ Cited Publications SCH 727965	CDK Apoptosis	Cancer
Dinaciclib (SCH 727965) is a potent inhibitor of *CDK, with IC₅₀s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9*, respectively ^[1].

HY-15777

Ribociclib Maximum Cited Publications 80 Publications Verification LEE011	CDK	Neurological Disease Cancer
RRibociclib (LEE011) is an ATP-competitive and orally active CDK4/6 inhibitor that crosses the blood-brain barrier with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex ^[1] .

HY-10580

GSK 3 Inhibitor IX 15+ Cited Publications 6-Bromoindirubin-3'-oxime; BIO; MLS 2052	GSK-3 CDK Apoptosis	Cancer
GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and *CDK1-cyclinB* complex with IC₅₀s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively.

HY-15777A

Ribociclib hydrochloride Maximum Cited Publications 80 Publications Verification LEE011 hydrochloride	CDK	Neurological Disease Cancer
RRibociclib (LEE011) hydrochloride is an ATP-competitive and orally active CDK4/6 inhibitor that crosses the blood-brain barrier with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex ^[1] .

HY-10329

JNJ-7706621 5 Publications Verification	Aurora Kinase CDK Apoptosis	Cancer
JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits *CDK1* and *CDK2, with IC₅₀s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A* and aurora-B, respectively ^[1] .

HY-10006

Flavopiridol Hydrochloride 50+ Cited Publications Alvocidib Hydrochloride; L86-8275 Hydrochloride; HMR-1275 Hydrochloride	CDK Autophagy HIV	Cancer
Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of *CDK, competing with ATP to inhibit CDKs* including CDK1, CDK2, CDK4 with IC₅₀s of 30, 170, 100 nM, respectively.

HY-18629

SU9516 5 Publications Verification	CDK Autophagy Apoptosis	Cancer
SU9516 is a potent *CDK2* inhibitor, with an IC₅₀ of 22 nM, and also shows inhibitory effects on CDK1 and CDK4, with IC₅₀s of 40, 200 nM, respectively.

HY-18340

(R)-CR8 1 Publications Verification CR8, (R)-Isomer	Molecular Glues CDK Apoptosis	Neurological Disease Cancer
(R)-CR8, a second-generation analog of Roscovitine, is a potent *CDK1/2/5/7/9* inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC₅₀=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect ^[1] . (R)-CR8 acts as a molecular glue degrader that depletes cyclin K .

HY-13914

Roniciclib 2 Publications Verification BAY 1000394	CDK	Cancer
Roniciclib is an orally bioavailable pan-cyclin dependent kinase *(CDK)* inhibitor, with IC₅₀s of 5-25 nM for CDK1, CDK2, CDK3, CDK4, CDK7 and CDK9.

HY-50940

AT7519 10+ Cited Publications AT7519M	CDK Apoptosis	Cancer
AT7519 (AT7519M) as a potent inhibitor of *CDKs, with IC₅₀s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK*9, respectively.

HY-122609

XO44 PF-6808472	CDK	Cancer
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in *CDK2 and CDK1. XO44 also labels CDK4* proteins in cells ^[1] .

HY-15569

NU6102	CDK	Cancer
NU6102 is a potent *CDK1* and *CDK2* inhibitor with IC₅₀s of 9.5 nM and 5.4 nM for *CDK1/cyclinB* and *CDK2/cyclinA3, respectively. NU6102 shows selectivity for CDK1/CDK2* over CDK4 (IC₅₀ of 1.6 μM), DYRK1A (IC₅₀ of 0.9 μM), PDK1 (IC₅₀ of 0.8 μM) and ROCKII (IC₅₀ of 0.6 μM) ^[1] .

HY-10014

R547 2 Publications Verification	CDK GSK-3 Apoptosis	Cancer
R547 is a potent, selective and orally active ATP-competitive *CDK* inhibitor, with K_is of 2 nM, 3 nM and 1 nM for CDK1/cyclin B, CDK2/cyclin E and CDK4/cyclin D1, respectively ^[1] .

HY-11001

PHA-793887 4 Publications Verification	CDK Apoptosis	Cancer
PHA-793887 is a potent, ATP-competitive *CDK* inhibitor, can inhibit Cdk2, Cdk1, Cdk4, and Cdk9 with IC₅₀s of 8 nM, 60 nM, 62 nM and 138 nM, respectively, and also inhibits glycogen synthase kinase 3β with an IC₅₀ of 79 nM.

HY-19807

Indirubin-3'-monoxime 4 Publications Verification Indirubin-3'-oxime	GSK-3 CDK Lipoxygenase	Cancer
Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC₅₀s of 22 nM and 7.8-10 µM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC₅₀s of 100 and 180 nM.

HY-117535

CDK2-IN-4 3 Publications Verification	CDK	Cancer
CDK2-IN-4 (compound 73) is a potent and selective *CDK2* inhibitor with an IC₅₀ of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC₅₀=86 uM) ^[1].

HY-137432

Avotaciclib 3 Publications Verification BEY1107	CDK Apoptosis	Cancer
Avotaciclib (BEY1107) is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib can be used in the research of cancer such as pancreatic cancer and lung cancer ^[1] .

HY-N5072

Desmethylglycitein 3 Publications Verification 4',6,7-Trihydroxyisoflavone	CDK PI3K PKC	Cancer
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to *CDK1* and *CDK2* in vivo, resulting in the suppresses CDK1 and CDK2 activity ^[1]. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-103647

K00546	CDK VEGFR GSK-3	Cancer
K00546 is a potent *CDK1* and *CDK2* inhibitor with IC₅₀s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. K00546 is also a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC₅₀s of 8.9 nM and 29.2 nM, respectively ^[1] .

HY-13266A

BS-181 hydrochloride 5+ Cited Publications	CDK	Cancer
BS-181 hydrochloride is a highly selective *CDK7* inhibitor with IC₅₀ of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.

HY-50914

AZD5597	CDK	Cancer
AZD5597 is an inhibitor of *CDK* with IC₅₀ values of both 2 nM for *CDK1* and *CDK2*. AZD5597 can inhibit the proliferation of tumor cells and has anti-tumor activity ^[1].

HY-50943

AT7519 Hydrochloride 10+ Cited Publications	CDK Apoptosis	Cancer
AT7519 Hydrochloride is a potent inhibitor of *CDKs, with IC₅₀s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK*9, respectively.

HY-16559

Riviciclib hydrochloride 3 Publications Verification P276-00	CDK Apoptosis	Cancer
Riviciclib hydrochloride (P276-00) is a potent cyclin-dependent kinase (CDK) inhibitor, which inhibits *CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB* with IC₅₀s of 20 nM, 63 nM, and 79 nM, respectively ^[1] . Riviciclib hydrochloride (P276-00) shows antitumor activity on cisplatin-resistant cells .

HY-124760

hSMG-1 inhibitor 11e 3 Publications Verification	mTOR PI3K CDK	Cancer
hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC₅₀ of <0.05 nM. hSMG-1 inhibitor 11e shows >900-fold selectivity over mTOR (IC₅₀ of 45 nM), PI3Kα/γ (IC₅₀s of 61 nM and 92 nM) and CDK1/CDK2 (IC₅₀s of 32 μM and 7.1 μM) ^[1].

HY-103221

MeBIO	Aryl Hydrocarbon Receptor GSK-3 CDK	Others
MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC₅₀ of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively ^[1].

HY-115565

CGP-74514	CDK Apoptosis	Cancer
CGP-74514 (Compound 13) is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC₅₀=25 nM). CGP-74514 inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G₂/M phase and induces tumor cell apoptosis. CGP-74514 is promising for research of bladder cancer ^[1] .

HY-114779

N9-Isopropylolomoucine	CDK	Cancer
N9-Isopropylolomoucine is a mitotic cyclin dependent kinase (CDK) inhibitor. N9-Isopropylolomoucine targets CCNB 1/CDK1 and can be used for cancer research ^[1].

HY-111930

5-Iodo-indirubin-3'-monoxime	GSK-3 CDK	Cancer
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, *CDK5/P25* and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC₅₀s of 9, 20 and 25 nM, respectively ^[1].

HY-129478

TC11 2 Publications Verification	Caspase Bcl-2 Family CDK	Cancer
TC11 is a *MCL1* degrader and Caspase-9 and *CDK1* activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of *MCL1* leading to apoptotic death ^[1] during prolonged mitotic arrest.

HY-13816

NU6027	CDK ATM/ATR	Cancer
NU6027 is a potent and ATP-competitive inhibitor of both *CDK1* and *CDK2, with K_is of 2.5 μM and 1.3 μM, respectively. NU6027 is also a potent inhibitor of ATR* and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner ^[1] .

HY-112463

CDK1-IN-2	CDK	Cancer
CDK1-IN-2 is a *CDK1* inhibitor (IC₅₀: 5.8 μM) ^[1].

HY-112462

Cdk1/2 Inhibitor III	CDK	Cancer
Cdk1/2 Inhibitor III (compound 3n) is a highly potent and selective Cdk1/cyclin B and Cdk2/cyclin A inhibitor of with IC₅₀s of 0.6 nM and 0.5 nM, respectively. Cdk1/2 Inhibitor III shows selectivity over VEGF-R2 (IC₅₀ of 32 nM), GSK-3β (IC₅₀ of 140 nM), and a other kinases. Cdk1/2 Inhibitor III inhibits in cell proliferation with IC₅₀s of 20 nM, 35 nM and 92 nM for HCT-116, HeLa, and A375 cells, respectively ^[1].

HY-50940A

AT7519 TFA 10+ Cited Publications AT7519M TFA	CDK	Cancer
AT7519 (AT7519M) TFA as a potent inhibitor of *CDKs, with IC₅₀s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK*9, respectively.

HY-137432A

Avotaciclib trihydrochloride 3 Publications Verification BEY1107 trihydrochloride	CDK Apoptosis	Cancer
Avotaciclib (BEY1107) trihydrochloride is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib trihydrochloride can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib trihydrochloride can be used in the research of cancer such as pancreatic cancer and lung cancer ^[1] .

HY-115924

CDK1-IN-1	CDK	Cancer
CDK1-IN-1 is a potent *CDK1* inhibitor (CDK1/CycB IC₅₀=161.2 nM) with potential antiproliferative activity and selectivity for cancer tissues. CDK1-IN-1 induces apoptosis in p53 dependent manner through the intrinsic apoptotic pathway. CDK1-IN-1 is a potential targeted antitumor agent ^[1].

HY-147646

CDK1/Cyc B-IN-1	CDK Apoptosis	Cancer
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC₅₀ of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines ^[1].

HY-RS02348

CDK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CDK	Others
CDK1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDK1 Human Pre-designed siRNA Set A CDK1 Human Pre-designed siRNA Set A

HY-103381

NSC693868	CDK GSK-3	Cancer
NSC693868 is a selective inhibitor of *CDK1* and *CDK5* with IC₅₀s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC₅₀ of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways ^[1].

HY-15612

CDK4-IN-1	CDK	Cancer
CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively.

HY-N11774

Euphornin	Apoptosis Caspase	Cancer
Euphornin is a anticaner agent, that can be isolated from E. helioscopia. Euphornin induces apoptosis via caspase-mediated pathways. Euphornin induces cell cycle arrest by increasing the level of the phospho-CDK1 (Tyr15) protein ^[1].

HY-19316

NU2058 O6-(Cyclohexylmethyl)guanine	CDK	Cancer
NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based *CDK* inhibitor with IC₅₀s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.

HY-168673

CDK1-IN-6	CDK	Cancer
CDK1-IN-6 (Ligand 3) is a potent *CDK1* inhibitor. CDK1-IN-6 has the potential for the research of cancer ^[1].

HY-P2480

Histone H1-derived Peptide	CDK	Others
Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDK, can be used to detecting CDK1-cyclinB1 enzyme activity ^[1] .

HY-112471

TrkA Inhibitor	CDK	Cancer
TrkA Inhibitor (Compound 18) is a *CDK2* inhibitor with an IC₅₀ of 0.69  μM over CDK1. TrkA Inhibitor can be used for chemotherapy-induced alopecia research ^[1].

HY-137432B

Avotaciclib hydrochloride 3 Publications Verification BEY1107 hydrochloride	CDK Apoptosis	Cancer
Avotaciclib (BEY1107) hydrochloride is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib hydrochloride can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib hydrochloride can be used in the research of cancer such as pancreatic cancer and lung cancer ^[1] .

HY-E70653

CDK1/CycB1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycB1 Recombinant Human Active Protein Kinase is an ortholog of CDK1. CDK1/cyclin B1 complexes initiates mitotic entry by phosphorylating a multitude of proteins to condense chromosomes, disrupt the nuclear envelope, and enable microtubules polymerization to attach and to segregate the chromosomes ^[1].

HY-118976

CGP-74514 hydrochloride CGP-74514A	CDK Apoptosis	Cancer
CGP-74514 hydrochloride is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC₅₀: 25 nM). CGP-74514 hydrochloride inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G₂/M phase and induces tumor cell apoptosis. CGP-74514 hydrochloride is promising for research of bladder cancer ^[1] .

HY-112336

Aloisine RP106	CDK GSK-3	Neurological Disease
Aloisine RP106 (compound 38) is a potent inhibitor of Cdk1/cyclin B, *Cdk5/p25, and GSK3* with IC₅₀s of 0.70µM, 1.5µM, 0.92 µM, respectively ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P2480

Histone H1-derived Peptide	CDK	Others
Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDK, can be used to detecting CDK1-cyclinB1 enzyme activity ^[1] .

HY-P11028

M1-20	CDK	Cancer
M1-20 is a *CDK1* inhibitor. M1-20 promotes CDK1 ubiquitination by CUL4-DDB1-DCAF1 complexes and degradation through the proteasome pathway. M1-20 abolishes the formation of CDK1/CCNB1 complexes. M1-20 has significant anticancer activity of spontaneous breast cancer in FVB/N MMTV-PyVT mice model ^[1].

HY-P5428

Cdc2 kinase substrate	CDK	Others
Cdc2 kinase substrate is a biological active peptide. (The native peptide HATPPKKKRK is a substrate for cyclin-dependent protein kinase 1 (CDC2; CDK1).)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0255

Adefovir dipivoxil 2 Publications Verification GS 0840	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	HBV Orthopoxvirus HSV DNA/RNA Synthesis ATM/ATR CDK
Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the *KCTD12-CDK1* interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer ^[1] .

HY-N0417

Cucurbitacin E Maximum Cited Publications 6 Publications Verification α-Elaterin; α-Elaterine	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Disease Research Fields Source Classification Cancer	CDK Autophagy PANoptosis
Cucurbitacin E is a *CDK1* inhibitor that significantly inhibits the activity of the cyclin B1/CDC2 complex. Cucurbitacin E also induces PANoptosis in adrenocortical carcinoma cells in a *ZBP1*-dependent manner. Cucurbitacin E exhibits synergistic effects with Mitotane (HY-13690); when used in combination, they effectively eliminate tumors ^[1] .

HY-N5072

Desmethylglycitein 3 Publications Verification 4',6,7-Trihydroxyisoflavone	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Phenols Polyphenols Plants Disease Research Fields Isoflavones Source Classification Cancer	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to *CDK1* and *CDK2* in vivo, resulting in the suppresses CDK1 and CDK2 activity ^[1]. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-N5112A

β,β-Dimethylacrylalkannin 3 Publications Verification Arnebin 1	Quinones Structural Classification other families Classification of Application Fields Other Diseases Plants Naphthalene Quinones Pteris livida Mett. Disease Research Fields	FGFR Necroptosis Apoptosis CDK JNK
β,β-Dimethylacrylalkannin (Arnebin 1) is an orally active *FGFR1* inhibitor (IC₅₀=2.5 μM) and the main active component of Lithospermum erythrorhizon. β,β-Dimethylacrylalkannin blocks downstream signaling by binding to the ATP pocket of FGFR1, and regulates the *CDK1/Cdc25C* pathway and ROS-JNK axis, thereby inducing G2/M phase arrest, necrosis and apoptosis in cancer cells, and inhibiting tumor proliferation. β,β-Dimethylacrylalkannin also acts as a colistin adjuvant to disrupt the cell membrane of Gram-negative bacteria. β,β-Dimethylacrylalkannin exhibits significant tumor-inhibitory effects with no obvious toxicity in PDX models, but chronic exposure to high doses may alter the relative lung/liver weights of rats, while acute exposure to high doses causes responses such as reduced motor activity. β,β-Dimethylacrylalkannin finds wide application in studies related to hepatocellular carcinoma, colorectal cancer, colistin-resistant bacterial infections, hepatitis and psoriasis ^[1] .

HY-157647

1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC PC(18:0/22:4)	Structural Classification Endogenous metabolite Lipid Source Classification	CDK Apoptosis
1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC (PC(18:0/22:4)) is an inhibitor of cyclin-dependent kinases (CDKs). 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC induces apoptosis and inhibits the growth of various cancer cell lines ^[1].

HY-N11774

Euphornin	Natural Products Euphorbia helioscopia L. Euphorbiaceae Plants Source Classification	Apoptosis Caspase
Euphornin is a anticaner agent, that can be isolated from E. helioscopia. Euphornin induces apoptosis via caspase-mediated pathways. Euphornin induces cell cycle arrest by increasing the level of the phospho-CDK1 (Tyr15) protein ^[1].

HY-N5072R

Desmethylglycitein (Standard) 4',6,7-Trihydroxyisoflavone (Standard)	Structural Classification Flavonoids Leguminosae Glycine max (L.) merr Phenols Polyphenols Plants Isoflavones Source Classification	Reference Standards CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity ^[1]. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-B0255R

Adefovir dipivoxil (Standard) GS 0840 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards HBV Reverse Transcriptase Orthopoxvirus Endogenous Metabolite
Adefovir dipivoxil (Standard) is the analytical standard of Adefovir dipivoxil. This product is intended for research and analytical applications. Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the *KCTD12-CDK1* interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer ^[1] .

HY-N12625

(R)-(+)-O-Demethylbuchenavianine	Alkaloids Flavonoids Flavones Other Alkaloids Buchenavia macrophylla Spruce ex Eichler Combretaceae Plants Source Classification	CDK DYRK GSK-3
(R)-(+)-O-Demethylbuchenavianine is an inhibitor for Cyclin-dependent kinases (CDK). (R)-(+)-O-Demethylbuchenavianine inhibits CDK1, CDK5, glycogen synthase kinase-3 (GSK3), cdc2-like kinase (CLK1) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), with IC₅₀s of 1.1, 0.95, >10, >10 and >10 μM, respectively ^[1].

HY-N11439

Albanol B	Natural Products Phenols Polyphenols Morus alba L. Plants Moraceae Source Classification	CDK Akt ERK Apoptosis Bacterial
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates *CDK1* expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and *ERK1/2* ^[1].

HY-N12625A

(S)-(-)-O-Demethylbuchenavianine	Alkaloids Flavonoids Flavones Other Alkaloids Buchenavia macrophylla Spruce ex Eichler Combretaceae Plants Source Classification	CDK
(S)-(-)-O-Demethylbuchenavianine (Compound (S)-(−)-1) is a flavonoidal alkaloids. (S)-(-)-O-Demethylbuchenavianine is a potent *CDK* inhibitor, with IC₅₀ values of 0.03 and 0.05 μM for CDK1 and CDK5, respectively ^[1].

Recombinant Proteins Recommended:

Cyclin Dependent Kinase 1 (CDK1)

Species:	Human (8) Mouse (1)
Tag:	His (6) Avi (1) GST (7) Flag (3)
Source:	sf9 insect cells (1) Sf9 insect cells (8)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702779

	CDK1 Protein, Human (Active, sf9) Cyclin-dependent kinase 1; Cdk1; p34 protein kinase; CDC2; CDC28A; CdkN1; P34CDC2	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1 Protein, Human (sf9) is the recombinant human-derived CDK1, expressed by Sf9 insect cells, with tag-free. The total length of CDK1 Protein, Human (sf9) is 297 a.a..

HY-P705799

	CDK1 Protein, Human (Biotinylated, sf9, Avi) Cyclin-dependent kinase 1; Cdk1; p34 protein kinase; CDC2; CDC28A; CdkN1; P34CDC2	Human	sf9 insect cells

HY-P75668

	CDK1 Protein, Human (Inactive, sf9, GST) Cyclin-dependent kinase 1; Cdk1; p34 protein kinase; CDC2; CDC28A; CdkN1; P34CDC2	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1 Protein, Human (sf9, GST) is the recombinant human-derived CDK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P75669

	CDK1 Protein, Mouse (sf9, His-GST) Cyclin-dependent kinase 1; Cdk1; p34 protein kinase; CDC2; CDC28A; CdkN1; P34CDC2	Mouse	Sf9 insect cells
	The CDK1 protein centrally controls the eukaryotic cell cycle, coordinating the G2-M transition and mitotic events. It interacts with a variety of cell cycle proteins, phosphorylates a variety of substrates, and affects cell cycle regulation, DNA repair, and apoptosis. CDK1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P74257

	CDK1-CCNE1 Heterodimer Protein, Human (Inactive, sf9, His-GST) Cyclin-dependent kinase 1; Cdk1; CDC2; G1/S-specific cyclin-E1; CCNE1	Human	Sf9 insect cells
	The FGF-9 protein undergoes autoproteolysis and cholesterol attachment in the endoplasmic reticulum. It acts as a morphogen during development, inducing ventral cell fate, participating in limb bud patterning, and aiding in axon guidance. FGF-9 binds to the PTCH1 receptor and activates target gene transcription when in association with SMO, while PTCH1 represses SMO signaling in the absence of FGF-9. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST) is a recombinant protein dimer complex containing human-derived CDK1-CCNE1 Heterodimer protein, expressed by Sf9 insect cells , with N-10*His, N-GST labeled tag. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST), has molecular weight of ~109.7 (60.4+49.3) kDa.

HY-P702736

	CDK1-CCNB1 Protein, Human (Active, sf9, GST, Flag, His) Cdk1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1-CCNB1 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK1-CCNB1, expressed by Sf9 insect cells, with N-GST, N-Flag, N-His labeled tag.

HY-P702671

	CDK1-CCNA2 Protein, Human (Active, sf9, GST, His) Cdk1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1-CCNA2 Protein, Human (sf9, GST, His) is the recombinant human-derived CDK1-CCNA2, expressed by Sf9 insect cells, with N-His, N-GST labeled tag.

HY-P702674

	CDK1-CCNE2 Protein, Human (Active, sf9, GST, His, Flag) Cdk1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1-CCNE2 Protein, Human (sf9, GST, His, Flag) is the recombinant human-derived CDK1-CCNE2, expressed by Sf9 insect cells, with N-His, N-GST, N-Flag labeled tag.

HY-P702673

	CDK1-CCNE1 Heterodimer Protein, Human (Active, sf9, GST, His, Flag) Cdk1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1-CCNE1 Heterodimer Protein, Human (sf9, GST, His, Flag) is the recombinant human-derived CDK1-CCNE1, expressed by Sf9 insect cells, with N-GST, N-Flag, N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-15777S

Ribociclib-d6
Ribociclib-d₆ (LEE011-d₆) is a deuterium labeled Ribociclib (HY-15777). Ribociclib is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex ^[1].

HY-15777AS

Ribociclib-d6 hydrochloride
Ribociclib-d₆ (LEE011-d₆) hydrochloride is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex ^[1].

HY-15777S1

Ribociclib-d8
Ribociclib-d₈ is the deuterium labeled Ribociclib ^[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex .

HY-176174S

CDK2-IN-46
CDK2-IN-46 (compound 5g) is a selective *CDK2* inhibitor with an IC₅₀ of 0.3 nM. CDK2-IN-46 has a selectivity of >200-fold for CDK1, CDK7, CDK9, CDK4, and CDK6. CDK2-IN-46 shows improves rat and cyno pharmacokinetic profiles ^[1].

Host:	Mouse (2) Rabbit (13)
Reactivity:	Human (15) Rat (4) Mouse (6) Hamster (2)
Application:	IHC-P (7) ICC/IF (5) IP (8) WB (15) FC (4) Dot Blot (1) ELISA (3)
Isotype:	IgG (13) IgG1 (2)
Conjugation:	Non-conjugated (15) Biotin (1)
Clonality:	Polyclonal (1) Monoclonal (5) Monoclonal Antibody (1) Recombinant (4)
Modification:	Phosphorylated (3) Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83973

	CDK1 Antibody (YA3670) CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; Cdk1	WB, ICC/IF, FC, ELISA	Human
	CDK1 Antibody (YA3670) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CDK1.

HY-P86404

	CDK1 Antibody (YA6096) Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse
	CDK1 Antibody (YA6096) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK1.

HY-P83973A

	CDK1 Antibody (YA3670)(PBS only) CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; Cdk1	WB, ICC/IF, FC, ELISA	Human
	CDK1 Antibody (YA3670) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CDK1.

HY-P80076

	CDK2 Antibody (YA514) 1 Publications Verification Cdc2 related protein kinase; CDC28; CDC2A; Cdk 2; Cdk1; Cdk2; Cdk2_HUMAN ; CdkN2; MPF; p33(Cdk2) antibody;	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
	CDK2 Antibody (YA514) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK2.

HY-P80611

	CDK1 Antibody (YA516) 2 Publications Verification Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB, IP	Human
	CDK1 Antibody (YA516) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK1.

HY-P80611A

	CDK1 Antibody (YA516)(PBS only) Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB, IP	Human
	CDK1 Antibody (YA516) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK1.

HY-P80796

	*Phospho-CDK1* (Tyr15) Antibody** Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB	Human, Mouse, Rat
	Phospho-CDK1 (Tyr15) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-CDK1 (Tyr15).

HY-P810643

	*Phospho-CDK1* (Thr161) Antibody (YA9905)** Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Phospho-CDK1 (Thr161) Antibody (YA9905) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-CDK1 (Thr161).

HY-P810644

	*Phospho-CDK1/2/3 (Thr14) Antibody (YA9906)* Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB, IHC-P	Human, Mouse, Rat
	Phospho-CDK/2/3 (Thr14) Antibody (YA9906) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-Cdk1/2/3 (Thr14).

HY-P810642

	*Phospho-CDK* (Tyr15) Antibody (YA9904)** Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB, IHC-P	Human, Mouse
	Phospho-CDK (Tyr15) Antibody (YA9904) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-CDK (Tyr15).

HY-P82827

	*Phospho-CDK1/2 (Thr14) Antibody (YA2572)* CdkN2; p33(Cdk2)	WB, IHC-P, IP	Human
	Phospho-CDK1/2 (Thr14) Antibody (YA2572) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CDK1/2 (Thr14).

HY-P82827A

	*Phospho-CDK1/2 (Thr14) Antibody (YA2572)(PBS only)* CdkN2; p33(Cdk2)	WB, IHC-P, IP	Human
	Phospho-CDK1/2 (Thr14) Antibody (YA2572) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CDK1/2 (Thr14).

HY-P80797

	*Phospho-CDK1/2/3 (Thr14) Antibody (YA218)* CDC2; CDC28A; P34CDC2	WB, IP	Human, Hamster
	Phospho-CDK1/2/3 (Thr14) Antibody (YA218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CDK1/2/3 (Thr14).

HY-P80797A

	*Phospho-CDK1/2/3 (Thr14) Antibody (YA218)(PBS only)* CDC2; CDC28A; P34CDC2	WB, IP	Human, Hamster
	Phospho-CDK1/2/3 (Thr14) Antibody (YA218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CDK1/2/3 (Thr14).

HY-P810605

	*Phospho-CDK1* (Thr161) + CDK2/CDK3 (Thr160) Antibody (YA9867)** Cdk2; CdkN2; Cyclin-dependent kinase 2; Cell division protein kinase 2; p33 protein kinase	WB, Dot Blot	Human
	Phospho-CDK1 (Thr161) + CDK2/CDK3 (Thr160) Antibody (YA9867) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-CDK1 (Thr161) + CDK2/CDK3 (Thr160).

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-122609

XO44 PF-6808472		Alkynes
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in *CDK2 and CDK1. XO44 also labels CDK4* proteins in cells ^[1] .

HY-116423

JH295		Alkynes
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint ^[1]. JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-116423A

JH295 hydrate		Alkynes
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint ^[1]. JH295 (hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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