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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
Charge transfer
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "Charge transfer" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W127832
CAS No.: 123148-15-2
Cat. No.: HY-W345885
CAS No.: 87-73-0
Target:
degradation of organic contaminants .
Target:
Research Areas:
BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro .
Cat. No.: HY-D0916
CAS No.: 143413-85-8
Synonyms: YOYO 1; YOYO1
Cat. No.: HY-W024271
CAS No.: 63149-33-7
Synonyms: 9-Formyl-8-hydroxyjulolidine
Target:
Research Areas:
8-Hydroxyjulolidine-9-carboxaldehyde (9-Formyl-8-hydroxyjulolidine) is a highly selective fluorescent probe for hydrogen sulfide (S 2−) and silicate (SiO3 2−). 8-Hydroxyjulolidine-9-carboxaldehyde operates via a mechanism of blocking intramolecular charge transfer (ICT), exhibiting significant fluorescence enhancement in the presence of weak acid ions. 8-Hydroxyjulolidine-9-carboxaldehyde is promising for research of fluorescence imaging of hydrogen sulfide within living cells .
Cat. No.: HY-W007392
CAS No.: 934-05-4
Synonyms: Methyl 4-bromopyrrole-2-carboxylate
Cat. No.: HY-D2479
CAS No.: 2978635-30-0
Cat. No.: HY-D1259
CAS No.: 2414276-32-5
Synonyms: VDP-green (NEP)
Cat. No.: HY-149203
Cat. No.: HY-124357
CAS No.: 127685-30-7
Synonyms: S-Norfluoxetine hydrochloride; LY 215229 hydrochloride
Target:
Research Areas:
Seproxetine (S-Norfluoxetine) hydrochloride is a selective serotonin reuptake inhibitor (SSRI) that enhances serotonin levels in the brain by specifically inhibiting the serotonin uptake carrier. Seproxetine hydrochloride exhibits strong charge transfer interactions with π-electron acceptors, forming stable complexes that enhance its binding affinity to multiple receptors, including serotonin and dopamine receptors. Seproxetine hydrochloride demonstrates improved biological activity when interacting with charge transfer complexes, leading to increased stability and efficacy in therapeutic applications.
Cat. No.: HY-149203A
Purity: 97.36%
Target:
Research Areas:
MQA-P is a multifunctional near-infrared (NIR) fluorescent probe that simultaneously detects ONOO -, viscosity, and polarity within mitochondria. MQA-P exhibits significant response to ONOO -, λem=645 nm; and NIR channel at λem>704 nm Medium is highly sensitive to viscosity/polarity. MQA-P possesses excited-state intramolecular charge transfer (ESICT) properties that are highly sensitive to polarity by designing the N,N-dimethylamino group as the electron donor and the quinoline cation unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .
Cat. No.: HY-W094110
CAS No.: 10028-22-5
Research Areas:
Iron (III) sulfate is a stable rhombohedral NASICON compound. Iron (III) sulfate can serve as a sodium ion intercalation host, enabling sodium ion intercalation and deintercalation via a single-phase mechanism relying on the Fe 2+/Fe 3+ redox couple. Iron (III) sulfate exhibits reversible electrochemical behavior and moderate polarization in cyclic voltammetry tests, and its charge transfer resistance changes during charge-discharge cycles. Iron (III) sulfate possesses a high redox potential, excellent rate capability, and long-cycle stability .
Cat. No.: HY-D3127
CAS No.: 455251-97-5
Target:
Research Areas:
DCA-Mln is a Fluorescent probe for ferric iron (Fe³⁺) detection. The probe works via an internal charge transfer (ICT) process from its diethylamino group to its dicyano group, which produces bright pink fluorescence in its unbound state; when Fe³⁺ is present, two molecules of DCA-Mln chelate with one Fe³⁺ ion, with one cyano group of each DCA-Mln participating in the complexation, and this binding triggers a photoinduced electron transfer (PET) process that provides a nonradiative deactivation pathway, resulting in fluorescence quenching; additionally, the probe exhibits a visible color change from purple to peach pink upon Fe³⁺ binding, enabling dual-channel detection. The probe has an excitation wavelength of 570 nm and an emission wavelength of 670 nm, and it shows a rapid response, with fluorescence stabilizing within 15 seconds of Fe³⁺ addition. DCA-Mln is cell-membrane-permeable, nontoxic at the imaging concentration of 10 μM, and can be used for Fe³⁺ detection in actual water samples, Fe³⁺ imaging in living cells, and as an anti-counterfeiting ink[1].
Cat. No.: HY-D3108
CAS No.: 2569032-08-0
Cat. No.: HY-D3118
CAS No.: 2989973-69-3
Target:
Research Areas:
Biotin-V is a fluorescent probe targeting the biotin receptor (BiR), which can be used to detect changes in intracellular viscosity in cancer cells and tumor tissues. Biotin-V consists of a viscosity-responsive TICT (twisted internal charge transfer) fluorophore and a biotin-targeting moiety. In a high-viscosity environment, intramolecular rotation is restricted, which reduces non-radiative transitions and enhances fluorescence intensity and fluorescence lifetime. Biotin-V enters BiR-positive cancer cells via biotin receptor-mediated uptake, and mainly localizes to mitochondria, enabling dual-modal viscosity imaging (fluorescence intensity imaging and fluorescence lifetime imaging) (Ex/Em = 540/608 nm; cell imaging Ex/Em = 561/570-620 nm) .
Cat. No.: HY-D3125
Target:
Research Areas:
NtHzBtd is a fluorescent probe for detecting Fe 3+. NtHzBtd is applicable to the selective fluorescent detection of Fe 3+ ions and live cell imaging studies. NtHzBtd can selectively coordinate with Fe 3+ to form a 1:1 complex, triggering chelation enhanced quenching (CHEQ) and intramolecular charge transfer (ICT) processes, which result in fluorescence turn-off, thereby enabling sensitive detection of Fe 3+ and live cell fluorescence imaging. After binding to Fe 3+, NtHzBtd reduces fluorescence intensity, exhibits a rapid response property, with a limit of detection of 0.036 μM and a response time of approximately 55 s. The detection wavelengths are Ex/Em = 334/401 nm (solution system) .
Cat. No.: HY-D3090
CAS No.: 2757682-04-3
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Research Areas:
NRLD is a lipid droplet-targeting solvatochromic fluorescent probe developed based on Nile Red (HY-D0718), which can target lipid droplets and sense the non-polar lipid microenvironment inside lipid droplets. NRLD exhibits superior lipid droplet-targeting selectivity compared to the parent Nile Red dye in HeLa cell imaging. NRLD achieves detection relying on the solvatochromic effect generated by excited-state charge transfer, and its emission wavelength shifts according to the local polarity changes of the microenvironment it locates in: the more compact and ordered the lipid packing and the lower the environmental polarity, the more blue-shifted the emission; the looser the lipid packing or the stronger the hydration and the higher the environmental polarity, the more red-shifted the emission. NRLD shows blue shift in the non-polar oil core of lipid droplets and red shift in high-polarity environments such as phosphate buffer .
Cat. No.: HY-D3105
Target:
Research Areas:
DCA is a Fluorescent probe for visualization of phase behavior in ER membranes. DCA is an ER-targeting, polarity-responsive NIR ratiometric probe, with its p-toluenesulfonamide group responsible for ER localization; its sensitivity to polarity relies on its donor-π-acceptor (D-π-A) structure, where aniline acts as the donor and dicyanomethylene acts as the acceptor, driving an intramolecular charge transfer (ICT) process upon excitation. In environments with low polarity, such as the closely packed, low water content ERₒ phase of ER membranes, DCA emits at a shorter wavelength, while in high polarity environments like the loosely packed, higher water content ERd phase, ICT leads to a red-shifted emission, allowing discrimination of the two phases via dual NIR emission colors and ratiometric imaging. Ex/Em = 488/570–620 nm and 488/665–735 nm; additional excitation/emission pairs include Ex/Em = 488/631 nm in low polarity 1,4-dioxane and Ex/Em = 488/677 nm in 1,4-dioxane with 30% water, the higher polarity condition. It shows a large Stokes shift of ~170 nm, and pH, viscosity, and biologically relevant species including Cys, GSH, H₂O₂, and metal ions do not exert marked interference on its fluorescence spectra[1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
