8-Hydroxyjulolidine-9-carboxaldehyde
Based on 1 Customer Validation
8-Hydroxyjulolidine-9-carboxaldehyde (9-Formyl-8-hydroxyjulolidine) is a highly selective fluorescent probe for hydrogen sulfide (S2−) and silicate (SiO32−). 8-Hydroxyjulolidine-9-carboxaldehyde operates via a mechanism of blocking intramolecular charge transfer (ICT), exhibiting significant fluorescence enhancement in the presence of weak acid ions. 8-Hydroxyjulolidine-9-carboxaldehyde is promising for research of fluorescence imaging of hydrogen sulfide within living cells.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 63149-33-7
- Formula: C13H15NO2
- Molecular Weight:217.26
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
>70 μM
Compound: 13
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Antiproliferative activity against mouse B16 cell line
Antiproliferative activity against mouse B16 cell line
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[PMID: 16793260] |
| DLD-1 | IC50 |
>70 μM
Compound: 13
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Antiproliferative activity against human DLD1 cell line
Antiproliferative activity against human DLD1 cell line
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[PMID: 16793260] |
| HeLa | IC50 |
>70 μM
Compound: 13
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Antiproliferative activity against human HeLa cell line
Antiproliferative activity against human HeLa cell line
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[PMID: 16793260] |
| HUVEC | IC50 |
35.4 μM
Compound: 13
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Antiproliferative activity against HUVEC cell line
Antiproliferative activity against HUVEC cell line
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[PMID: 16793260] |
| NIH3T3 | IC50 |
>70 μM
Compound: 13
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Antiproliferative activity against mouse NIH3T3 cell line
Antiproliferative activity against mouse NIH3T3 cell line
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[PMID: 16793260] |
| Sf21 | IC50 |
>20000 nM
Compound: 10
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Inhibition of human recombinant puritin-His-tagged IRE-1 RNase expressed in SF21 cells using XBP-1 RNA stem loop as substrate incubated for 30 mins prior to substrate addition measured after 2 hrs by FRET-suppression assay
Inhibition of human recombinant puritin-His-tagged IRE-1 RNase expressed in SF21 cells using XBP-1 RNA stem loop as substrate incubated for 30 mins prior to substrate addition measured after 2 hrs by FRET-suppression assay
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[PMID: 24749861] |
| SiHa | IC50 |
>70 μM
Compound: 13
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Antiproliferative activity against human SiHa cell line
Antiproliferative activity against human SiHa cell line
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[PMID: 16793260] |
| U-87MG ATCC | IC50 |
>70 μM
Compound: 13
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Antiproliferative activity against human U87 MG cell line
Antiproliferative activity against human U87 MG cell line
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[PMID: 16793260] |
Chemical Information
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CAS No. 63149-33-7
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Appearance Solid
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Molecular Weight 217.26
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Formula C13H15NO2
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SMILES
O=CC1=C(O)C2=C3N(CCC2)CCCC3=C1
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Synonyms
9-Formyl-8-hydroxyjulolidine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (230.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6028 mL | 23.0139 mL | 46.0278 mL | 115.0695 mL |
| 5 mM | 0.9206 mL | 4.6028 mL | 9.2056 mL | 23.0139 mL | |
| 10 mM | 0.4603 mL | 2.3014 mL | 4.6028 mL | 11.5070 mL | |
| 15 mM | 0.3069 mL | 1.5343 mL | 3.0685 mL | 7.6713 mL | |
| 20 mM | 0.2301 mL | 1.1507 mL | 2.3014 mL | 5.7535 mL | |
| 25 mM | 0.1841 mL | 0.9206 mL | 1.8411 mL | 4.6028 mL | |
| 30 mM | 0.1534 mL | 0.7671 mL | 1.5343 mL | 3.8357 mL | |
| 40 mM | 0.1151 mL | 0.5753 mL | 1.1507 mL | 2.8767 mL | |
| 50 mM | 0.0921 mL | 0.4603 mL | 0.9206 mL | 2.3014 mL | |
| 60 mM | 0.0767 mL | 0.3836 mL | 0.7671 mL | 1.9178 mL | |
| 80 mM | 0.0575 mL | 0.2877 mL | 0.5753 mL | 1.4384 mL | |
| 100 mM | 0.0460 mL | 0.2301 mL | 0.4603 mL | 1.1507 mL |
8-Hydroxyjulolidine-9-carboxaldehyde Related Classifications
HY-W024271 Related Classifications
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