2569032-08-0
Chemical Structure
BV-1
- CAS No.: 2569032-08-0
- Formula:C24H27BF2N2O2
- Molecular Weight:424.29
InChIKey: QGGHTXINNZRAHE-CSKARUKUSA-N
SMILES: CCC1=C(C)N2[B-](F)(F)[N+]3=C(C)C(C)=C(C)C3=C(/C=C/C4=CC(O)=CC=C4O)C2=C1C
Biological Activity: BV-1 is a fluorescent probe for viscosity detection and imaging in living cells. BV-1 can be used to detect changes in intracellular viscosity and mitochondrial viscosity in living cells. BV-1 responds to environmental viscosity via a molecular rotor mechanism. In a low-viscosity environment, the centrally located unsaturated structure induces a twisted intramolecular charge transfer (TICT) state and promotes non-radiative transitions, resulting in fluorescence quenching; when viscosity increases, molecular rotation is restricted, the TICT state is attenuated, and fluorescence is enhanced with a red shift. BV-1 can be used for real-time monitoring of changes in cytoplasmic viscosity and the viscosity increase during cell apoptosis. Ex/Em = 480/570 nm[1].
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BV-1 | BV-1 is a fluorescent probe for viscosity detection and imaging in living cells. BV-1 can be used to detect changes in intracellular viscosity and mitochondrial viscosity in living cells. BV-1 responds to environmental viscosity via a molecular rotor mechanism. In a low-viscosity environment, the centrally located unsaturated structure induces a twisted intramolecular charge transfer (TICT) state and promotes non-radiative transitions, resulting in fluorescence quenching; when viscosity increases, molecular rotation is restricted, the TICT state is attenuated, and fluorescence is enhanced with a red shift. BV-1 can be used for real-time monitoring of changes in cytoplasmic viscosity and the viscosity increase during cell apoptosis. Ex/Em = 480/570 nm. | |||||||||||||||||||||
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