1 Result for "

Clausenidin

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Clausenidin" in MCE Product Catalog:

Clausenidin
Clausenidin
0 Images
Cat. No.: HY-N16771
CAS No.: 28384-44-3
Category:  

Rutaceae Coumarins Phenylpropanoids Plants Clausena excavata N. L. Burman

Target:  

Caspase Apoptosis Bcl-2 Family Bacterial VEGFR

Clausenidin is a selective inhibitor targeting apoptosis-related pathways, including the mitochondrial pathway and death receptor pathway, and vascular endothelial growth factor (VEGF). Clausenidin induces mitochondrial membrane depolarization by activating caspase-3, caspase-8 and caspase-9, upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-2. Clausenidin also inhibits VEGF expression and blocks angiogenesis, exerting anti-tumor activity. Clausenidin has inhibitory effects against Mycobacterium tuberculosis (MIC=200 μg/mL). Clausenidin can induce apoptosis in liver cancer cells, arrest the cell cycle in the G2/M phase, and inhibit tumor angiogenesis. Clausenidin can be used in the research of malignant tumors such as liver cancer .
loading...
    loading...
View All Sizes
Assay Types