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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
DM1 cells
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "DM1 cells" in MCE Product Catalog:
Cat. No.: HY-P991501
Synonyms: HcHAb18
Cat. No.: HY-P99492
CAS No.: 400010-39-1
Synonyms: SB-408075; huC242-DM1
Research Areas:
Cat. No.: HY-132260
CAS No.: 1607824-64-5
Synonyms: IMGN529; Debio 1562
Research Areas:
Cat. No.: HY-107502
CAS No.: 1260431-28-4
Cat. No.: HY-P991661
CAS No.: 1607838-85-6
Research Areas:
Cat. No.: HY-P10567
Cat. No.: HY-175834
Research Areas:
DNA/TOP2A-IN-1 is an inhibitor of DNA and TOP2A. DNA/TOP2A-IN-1 selectively binds to TOP2A, not TOP2B, and interacts with DNA and TOP2A to form a stable DM1-TOP2A-DNA ternary complex. DNA/TOP2A-IN-1 induces DNA damage, increases reactive oxygen species (ROS) and triggers apoptosis in triple-negative breast cancer (TNBC) cells. DNA/TOP2A-IN-1 disrupts microtubule distribution and induces cell cycle arrest. DNA/TOP2A-IN-1 shows strong antiproliferative activity and inhibits cell migration. DNA/TOP2A-IN-1 inhibits tumor growth and can be used for TNBC research .
Cat. No.: HY-114567
CAS No.: 1093294-48-4
Target:
Research Areas:
GW780056X is a CDK12 inhibitor. GW780056X decreases nuclear foci count in DM1 cells. GW780056X can be used for the research of myotonic dystrophy type 1 .
Cat. No.: HY-185483
Research Areas:
AMG-172 is an antibody-drug conjugate (ADC) composed of a fully human IgG1 monoclonal anti-CD27L antibody conjugated to DM1 (HY-19792) via the non-cleavable linker MCC. AMG-172 releases the intracellular active component Lysine-MCC-DM through catabolism. Lysine-MCC-DM inhibits the assembly and disassembly dynamics of Microtubule and induces cell arrest at metaphase. AMG-172 can be used for research on relapsed/refractory clear cell renal cell carcinoma .
Cat. No.: HY-173503
CAS No.: 1598439-44-1
Target:
Research Areas:
DS-1150b is an orally active GLUT4 activator. DS-1150b has the activity of activating GLUT4 transport and can promote the translocation of GLUT4 to the cell membrane in skeletal muscle cells. DS-1150b has shown hypoglycemic effects in the Zucker obese rat model and can be used in the study of type 2 diabetes mellitus (T2DM) .
Cat. No.: HY-184323
Target:
Research Areas:
PPARγ agonist-24 is a peroxisome proliferator-activated receptor gamma agonist with oral effectiveness, a PPARγ IC50 of 1.752 μM, and a PPARγ Ki of 54.81 nM. PPARγ agonist-24 shows higher selectivity toward PPARγ than PPARα and weak activity toward PPARδ. PPARγ agonist-24 enhances PPARγ protein expression in hepatic cells. PPARγ agonist-24 can be used for the research of type 2 diabetes (t2dm) .
Cat. No.: HY-147262
Research Areas:
Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
