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Cat. No.: HY-184323

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PPARγ agonist-24

PPARγ agonist-24 is a peroxisome proliferator-activated receptor gamma agonist with oral effectiveness, a PPARγ IC₅₀ of 1.752 μM, and a PPARγ K_i of 54.81 nM. PPARγ agonist-24 shows higher selectivity toward PPARγ than PPARα and weak activity toward PPARδ. PPARγ agonist-24 enhances PPARγ protein expression in hepatic cells. PPARγ agonist-24 can be used for the research of type 2 diabetes (t2dm).

For research use only. We do not sell to patients.

Formula: C₂₉H₂₅NO₅S
Molecular Weight:499.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PPARγ agonist-24 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

PPARγ

1.752 μM (IC₅₀)

PPARγ

54.81 nM (Ki)

In Vitro

PPARγ agonist-24 (Compound 7o) potently binds to the purified ligand-binding domain of PPARγ, with an IC₅₀ of 1.752 μM and a K_i of 54.81 nM^[1].
PPARγ agonist-24 (10-50 μM, 48 h) significantly upregulates the expression of PPARγ protein in HepG-2 cells in a dose-dependent manner in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

HepG-2 cells
Concentration:

0, 10, 25, 50 μM
Incubation Time:

48 h
Result:

Showed a dose-dependent increase in PPARγ protein expression, with 1.22-fold and 1.41-fold increases at 25 μM and 50 μM, respectively.

Chemical Information

Molecular Weight 499.58
Formula C₂₉H₂₅NO₅S
SMILES

O=S(C1=CC=CC=C1)(NC2=CC=C(C(/C=C/C3=CC=CC(OCC4=CC=C(OC)C=C4)=C3)=O)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ali IH, et al.. Discovery of novel chalcone-benzenesulfonamide conjugates as PPARγ agonists: Design, synthesis, and biological evaluation. European journal of medicinal chemistry. 2026 Jun 02;316:119024. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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