2. Metabolic Enzyme/Protease
  3. PGC-1α
  4. PPARγ agonist-24

PPARγ agonist-24 is a peroxisome proliferator-activated receptor gamma agonist with oral effectiveness, a PPARγ IC50 of 1.752 μM, and a PPARγ Ki of 54.81 nM. PPARγ agonist-24 shows higher selectivity toward PPARγ than PPARα and weak activity toward PPARδ. PPARγ agonist-24 enhances PPARγ protein expression in hepatic cells. PPARγ agonist-24 can be used for the research of type 2 diabetes (t2dm).

For research use only. We do not sell to patients.

PPARγ agonist-24

PPARγ agonist-24 Chemical Structure

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PPARγ agonist-24 Related Antibodies

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Description

PPARγ agonist-24 is a peroxisome proliferator-activated receptor gamma agonist with oral effectiveness, a PPARγ IC50 of 1.752 μM, and a PPARγ Ki of 54.81 nM. PPARγ agonist-24 shows higher selectivity toward PPARγ than PPARα and weak activity toward PPARδ. PPARγ agonist-24 enhances PPARγ protein expression in hepatic cells. PPARγ agonist-24 can be used for the research of type 2 diabetes (t2dm)[1].

IC50 & Target

PPARγ

1.752 μM (IC50)

PPARγ

54.81 nM (Ki)

In Vitro

PPARγ agonist-24 (Compound 7o) potently binds to the purified ligand-binding domain of PPARγ, with an IC50 of 1.752 μM and a Ki of 54.81 nM[1].
PPARγ agonist-24 (10-50 μM, 48 h) significantly upregulates the expression of PPARγ protein in HepG-2 cells in a dose-dependent manner in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PPARγ agonist-24 Related Antibodies

Immunofluorescence[1]

Cell Line: HepG-2 cells
Concentration: 0, 10, 25, 50 μM
Incubation Time: 48 h
Result: Showed a dose-dependent increase in PPARγ protein expression, with 1.22-fold and 1.41-fold increases at 25 μM and 50 μM, respectively.
Molecular Weight

499.58

Formula

C29H25NO5S
SMILES

O=S(C1=CC=CC=C1)(NC2=CC=C(C(/C=C/C3=CC=CC(OCC4=CC=C(OC)C=C4)=C3)=O)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PPARγ agonist-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARγ agonist-24PPARγ agonist24PPARγ agonist 24PGC-1αPPARγ coactivator-1αperoxisome proliferator-activated receptor gammaHepG-2 cellstype 2 diabetesPPARαPPARγPPARδPPARγ ligand-binding domainhepatic cellsInhibitorinhibitorinhibit

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PPARγ agonist-24
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HY-184323
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