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Cat. No.: HY-114567

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GW780056X

GW780056X is a CDK12 inhibitor. GW780056X decreases nuclear foci count in DM1 cells. GW780056X can be used for the research of myotonic dystrophy type 1.

For research use only. We do not sell to patients.

CAS No.: 1093294-48-4
Formula: C₂₁H₂₃N₇
Molecular Weight:373.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GW780056X Chemical Structure

CAS No.: 1093294-48-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

GW780056X is a CDK12 inhibitor. GW780056X decreases nuclear foci count in DM1 cells. GW780056X can be used for the research of myotonic dystrophy type 1^[1].

IC₅₀ & Target^[1]

CDK12

All CDK Isoforms :

In Vitro

GW780056X (0.1-10 μM; 24 h) reduces nuclear foci in DM1 fibroblast cells in a dose-dependent manner^[1].
GW780056X (2 μM) binds to CDK12 in K562 cell extracts, and this binding affinity correlates strongly with its nuclear foci-reducing activity in DM1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1093294-48-4
Molecular Weight 373.46
Formula C₂₁H₂₃N₇
SMILES

N1=CC=C(N=C1NC2=CC=CC(=C2)CN(CC)CC)C=3C=NN4N=CC=CC34
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ketley A, et al. CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model. Sci Transl Med. 2020;12(541):eaaz2415. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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GW780056X

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GW780056X Related Classifications

HY-114567 Related Classifications