Search Result

Isoforms Recommended:	ERK5

Results for "

ERK5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ERK (25) Apoptosis (2) Autophagy (1) Bcl-2 Family (1) CaMK (1) Caspase (1) E3 Ligase Ligand-Linker Conjugates (1) Epigenetic Reader Domain (1) Ferroptosis (2) FGFR (1) Ligands for Target Protein for PROTAC (1) MEK (3) mTOR (1) p62 (1) PROTAC Linkers (1) PROTACs (2) Reactive Oxygen Species (ROS) (2) Reference Standards (2) Small Interfering RNA (siRNA) (3) TNK1 (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Screening Libraries

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: ERK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-176528

*PROTAC ERK5* degrader-1**	ERK PROTACs	Cancer
PROTAC ERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. PROTAC ERK5 degrader-1 induces ERK5 degradation via VHL-mediated proteasome pathway in MOLT-4 cells. PROTAC ERK5 degrader-1 can be used for the study of a disease or disorder characterized by aberrant ERK5 activity, such as acute lymphoblastic leukemia .

HY-128341

ERK5-IN-2	ERK	Cardiovascular Disease Cancer
ERK5-IN-2 is an orally active, sub-micromolar, selective *ERK5* inhibitor with IC₅₀s of 0.82 μM, 3 μM for *ERK5* and ERK5 MEF2D, respectively. ERK5-IN-2 does not interact with the BRD4 bromodomain. ERK5-IN-2 suppresses both tumor xenograft growth and basic fibroblast growth factor (bFGF) driven Matrigel plug angiogenesis .

HY-12056

BIX02189 5+ Cited Publications	MEK ERK	Cancer
BIX02189 is a potent and selective *MEK5* inhibitor with an IC₅₀ of 1.5 nM. BIX02189 also inhibits *ERK5* catalytic activity with an IC₅₀ of 59 nM.

HY-14443

XMD8-92 Maximum Cited Publications 15 Publications Verification	Epigenetic Reader Domain ERK TNK1 CaMK	Cancer
XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with K_ds of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with K_ds of 190, 600 and 890 nM, respectively. Anti-cancer activity .

HY-108886

JWG-071 5 Publications Verification	ERK	Cancer
JWG-071 is the kinase-selective chemical probe for *ERK5. JWG-071 inhibits ERK5* and LRRK2 with IC₅₀ values of 88nM and 109 nM, respectively .

HY-14403

ERK5-IN-1	ERK	Cancer
ERK5-IN-1 is a potent *ERK5* inhibitor with an IC₅₀ of 87±7 nM. ERK5-IN-1 also inhibits LRRK2[G2019S] with an IC₅₀ of 26 nM.

HY-15665

XMD17-109 5+ Cited Publications	ERK	Cancer
XMD17-109 is a novel, specific *ERK-5* inhibitor, with an IC₅₀ of 162 nM.

HY-101846

AX-15836 5+ Cited Publications	ERK	Inflammation/Immunology Cancer
AX-15836 is a potent and selective *ERK5* inhibitor with an IC₅₀ of 8 nM.

HY-112082

BAY885 1 Publications Verification	ERK	Cancer
BAY885, a chemical probe, is a highly potent and selective *ERK5* inhibitor with an IC₅₀ of 35 nM. BAY885 shows weak inhibition on others kinases .

HY-12055

BIX02188 3 Publications Verification	MEK ERK	Cancer
BIX02188 is a potent *MEK5*-selective inhibitor with an IC₅₀ of 4.3 nM. BIX02188 inhibits *ERK5* catalytic activity, with an IC₅₀ of 810 nM.

HY-43191

tert-Butyl 6-bromohexanoate	PROTAC Linkers	Cancer
tert-Butyl 6-bromohexanoate is a PROTAC linker. tert-Butyl 6-bromohexanoate can be used to design PROTAC, such as PROTAC ERK5 degrader-1 (HY-176528) .

HY-149616

PPM-3	PROTACs ERK	Cancer
PPM-3 is a potent and selective PROTAC ERK5 degrader, with an IC₅₀ of 62.4 nM. PPM-3 did not influence tumor cell growth directly. PPM-3 influences tumor development by affecting the differentiation of macrophages .

HY-15813

FIIN-1 FGFR irreversible inhibitor-1	FGFR	Cancer
FIIN-1 is a potent, irreversible, selective FGFR inhibitor. FIIN-1 binds to FGFR1/2/3/4 and Flt1/4 with K_ds of 2.8/6.9/5.4/120 nM and 32/120 nM respectively. The biochemical IC₅₀s of FIIN-1 are 9.2, 6.2, 11.9, and 189 nM against FGFR1/2/3/4, respectively .

HY-176529

ERK5 ligand-1	Ligands for Target Protein for PROTAC ERK	Cancer
ERK5 ligand-1 is a is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). ERK5 ligand-1 can be used to design PROTAC, such as PROTAC ERK5 degrader-1 (HY-176528) .

HY-156450

ERK5-IN-5	ERK	Cancer
ERK5-IN-5 (compound 4a) is an *ERK5* kinase inhibitor with anticancer activity. ERK5-IN-5 exhibits good anti-proliferative activity with the IC₅₀ value of 6.23 µg/mL for A549 cells .

HY-173119

SKLB-D18	ERK Autophagy Apoptosis p62 mTOR Reactive Oxygen Species (ROS) Ferroptosis	Cancer
SKLB-D18 is an orally active *ERK1/2/ERK5* inhibitor, with an IC₅₀ of 38.69 nM and a K_d of 126.9 nM against human *ERK1, an IC₅₀* of 40.12 nM and a K_d of 209.8 nM against *ERK2, and an IC₅₀* of 59.72 nM and a K_d of 468.2 nM against *ERK5. SKLB-D18 inhibits cancer cell proliferation, induces G0/G1 cell cycle arrest and apoptosis. SKLB-D18 reduces the levels of p-ERK5, p-RSKp90, p-c-Myc* and c-Myc, and upregulates the level of *p-ERK1/2, thereby inhibiting the ERK1/2/5 pathway in cells. SKLB-D18 increases LC3B-II* accumulation, and decreases the levels of p62, p-mTOR and p-p70S6K. SKLB-D18 elevates the levels of ROS, lipid peroxidation and free ferrous ions, reduces the levels of NCOA4 and GPX4, and induces ferritin autophagy-dependent ferroptosis in cancer cells. SKLB-D18 exhibits antitumor activity in a triple-negative breast cancer xenograft mouse model. SKLB-D18 can be used in research related to triple-negative breast cancer .

HY-150606

ERK5-IN-4	ERK	Cancer
ERK5-IN-4 (compound 34b) is a potent and selective inhibitor of extracellular signal-related kinase 5 (ERK5). ERK5-IN-4 inhibits *ERK5* (full-length) and truncated ERK5 (ERK5 ΔTAD) kinase activity in HEK293 cells with an IC₅₀ of 77 nM and 300 nM, respectively .

HY-156451

ERK5-IN-6	ERK	Cancer
ERK5-IN-6 (compound 5J) is an *ERK5* kinase inhibitor with anticancer activity. ERK5-IN-6 exhibits good anti-proliferative activity with the IC₅₀ value of 4.56 µg/mL for A549 cells .

HY-149412

MHJ-627	ERK	Cancer
MHJ-627 is a potent *ERK5* (MAPK7) inhibitor (IC₅₀: 0.91 μM). MHJ-627 promotes the mRNA expression of tumor suppressors and anti-metastatic genes, and promotes cancer cell death .

HY-107622

(E/Z)-BIX02188	ERK MEK	Metabolic Disease
(E/Z)-BIX02188 is a MEK5/ERK5 pathway inhibitor. (E/Z)-BIX02188 inhibits the catalytic function of purified MEK5 enzyme.(E/Z)-BIX02188 can be used for the role of MEK5/ERK5 pathway in various biological systems .

HY-150605

ERK5-IN-3	ERK	Cancer
ERK5-IN-3 (compound 33j) is a potent and selective *ERK5* (extracellular signal-related kinase 5) inhibitor, with an IC₅₀ of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC₅₀ of 31 nM .

HY-181477

ERK5-IN-7	ERK Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)	Cancer
ERK5-IN-7 is an orally active *ERK5* inhibitor with an IC₅₀ of 403.4 nM. ERK5-IN-7 directly inhibits *ERK5* kinase activity, and downregulates the phosphorylation level and total protein expression of *ERK5. ERK5-IN-7* induces Apoptosis (upregulates Bax, downregulates Bcl-2, and induces Caspase-3 cleavage). ERK5-IN-7 induces ROS accumulation. ERK5-IN-7 exhibits anticancer effects against Lewis lung cancer .

HY-138215

ADTL-EI1712	ERK	Cancer
ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of *ERK1* and *ERK5, inhibition rates of ERK*1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo .

HY-181968

JWG-045	ERK Ferroptosis	Cancer
JWG-045 is a selective *ERK5* inhibitor. JWG-045 exhibits unique ferroptosis-resistant activity independent of ERK5 inhibition. JWG-045 can be used in breast cancer research .

HY-182398

BAY-693	ERK	Cancer
BAY-693 is a highly potent and highly selective *ERK5* inhibitor with an IC₅₀ of 6.40 μM. BAY-693 reduces the transcriptional activity of MEF2. BAY-693 is applicable for cancer research .

HY-108886R

JWG-071 (Standard)	Reference Standards ERK	Cancer
JWG-071 (Standard) is the analytical standard of JWG-071 (HY-108886). This product is intended for research and analytical applications. JWG-071 is the K_inase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC₅₀ values of 88nM and 109 nM, respectively .

HY-101846R

AX-15836 (Standard)	Reference Standards ERK	Inflammation/Immunology Cancer
AX-15836 (Standard) is the analytical standard of AX-15836 (HY-101846). This product is intended for research and analytical applications. AX-15836 is a potent and selective ERK5 inhibitor with an IC₅₀ of 8 nM.

HY-RS08119

Mapk7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mapk7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mapk7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mapk7 Mouse Pre-designed siRNA Set A Mapk7 Mouse Pre-designed siRNA Set A

HY-RS08120

MAPK7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAPK7 Rat Pre-designed siRNA Set A contains three designed siRNAs for MAPK7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAPK7 Rat Pre-designed siRNA Set A MAPK7 Rat Pre-designed siRNA Set A

HY-RS08118

MAPK7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAPK7 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAPK7 Human Pre-designed siRNA Set A MAPK7 Human Pre-designed siRNA Set A

HY-176530

(S,R,S)-AHPC-Me-amide-C4-Br	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-amide-C4-Br incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-Me-amide-C4-Br can be used to design PROTAC, such as PROTAC ERK5 degrader-1 (HY-176528) .

Cat. No.	Product Name

HY-L010

MAPK Compound Library	1,063 compounds
MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers. MCE designs a unique collection of 1,063 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

MAPK Compound Library

1,063 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 1,063 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703179

	MAPK7 Protein, Human BMK1; ERK5; PRKM7	Human	E. coli
	MAPK7 Protein, Human is the recombinant human-derived MAPK7, expressed by E. coli , with tag Free labeled tag. ,

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Rat (2) Mouse (3)
Application:	IHC-P (3) ICC/IF (2) IP (2) WB (3) FC (1) ELISA (3)
Isotype:	IgG (1) IgG1 (2) IgG/Kappa (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84530

	ERK5 Antibody (YA4227) BMK1; ERK4; ERK5; PRKM7	IHC-P, ELISA	Human
	ERK5 Antibody (YA4227) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ERK5.

HY-P84530A

	ERK5 Antibody (YA4227)(PBS only) BMK1; ERK4; ERK5; PRKM7	IHC-P, ELISA	Human
	ERK5 Antibody (YA4227) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ERK5.

HY-P80122

	ERK5 Antibody (YA451)	WB, ICC/IF, IP, FC	Human, Mouse
	ERK5 Antibody (YA451) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK5.

HY-P86354

	ERK5 Antibody (YA6046) MAPK7; BMK1; ERK5; PRKM7; Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ERK5 Antibody (YA6046) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK5.

HY-P85724

	ERK5 Antibody (YA5416)	IHC-P, WB	Human, Mouse, Rat
	ERK5 Antibody (YA5416) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ERK5.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Mapk7 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mapk7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mapk7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: