PPM-3
Based on 1 Customer Validation
PPM-3 is a potent and selective PROTAC ERK5 degrader, with an IC50 of 62.4 nM. PPM-3 did not influence tumor cell growth directly. PPM-3 influences tumor development by affecting the differentiation of macrophages.
For research use only. We do not sell to patients.
- Purity: 98.2%
- CAS No.: 3032388-42-1
- Formula: C54H69N11O6S
- Molecular Weight:1000.26
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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ERK5 62.4 ± 18. nM (IC50) |
PPM-3 (200 nM, 0-72 h, A375 cells)-mediated degradation of ERK5 begins within 2-4 h and that degradation peaks at 12 h and lasts at least 72 h[1].
PPM-3 (0-1 μM, 12 h) shows ERK5 degradation activity in H1975, HepG2, MDA-MB-231, PC-3, HCT116, and A375 cancer cell lines, with DC50 values of 11.5+2.5, 13.7+8.2, 22.7+13.3, 23.5+10.3, 5.6+1.9, and 41.4+22.3 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3032388-42-1
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Appearance Solid
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Molecular Weight 1000.26
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Formula C54H69N11O6S
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Color White to off-white
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SMILES
O=C(C1=CC=CC=C1N(C)C2=NC(NC3=CC=C(C=C3OC)N4CCN(CC4)CCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(N[C@H](C6=CC=C(C=C6)C7=C(N=CS7)C)C)=O)O)=O)=O)=NC=C28)N8C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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