188 Results for "

Fc-gamma

" in MedChemExpress (MCE) Product Catalog:
Products (188)

188 Results for "Fc-gamma" in MCE Product Catalog:

25
25 Publications Verification
Cat. No.: HY-P1731C
Synonyms: LY3298176 sodium
Tirzepatide sodium (LY3298176 sodium) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide sodium exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide sodium can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .
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2 Cited Publications
Cat. No.: HY-P73252
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IFNG; IMD69; Interferon gamma; IFG; IFN-gamma; IFI; Immune Interferon
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2 Cited Publications
Cat. No.: HY-P70669
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: High affinity immunoglobulin gamma Fc receptor I; Fcgr1; FcRI; CD64; Fc receptor; IgG; high affinity I
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1 Cited Publications
Cat. No.: HY-P70771
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGHG4; Immunoglobulin Heavy Constant gamma 4; Immunoglobulin Heavy Constant gamma 4 (G4m Marker); Ig gamma-4 Chain C Region; Immunoglobulin Heavy Chain Constant Region gamma 4
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1 Cited Publications
Cat. No.: HY-P72603
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Ig gamma-2A chain C region; Immunoglobulin heavy chain gamma polypeptide; Ighg
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1 Cited Publications
Cat. No.: HY-P70705
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FcGR3A; CD16; Prev. FcGR3; Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16); Prev. FcG3; Fc Of IgG Low Affinity IIIa Receptor Isoform 2; FcgammaRIIIa; Fc Of IgG Low Affinity IIIa Receptor Isoform 1; FcGRIIIA; Immunoglobulin G Fc Receptor III; CD
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1 Cited Publications
Cat. No.: HY-P70601
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FcGRT; Major Histocompatibility Complex Class I-Like Fc Receptor; Fc gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal
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1 Cited Publications
Cat. No.: HY-P7508
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ANGPTL4; Peroxisome Proliferator-Activated Receptor (PPAR) gamma Induced Angiopoietin-Related Protein; Angiopoietin Like 4; Hepatic Angiopoietin-Related Protein; HFARP; PPARG Angiopoietin Related Protein; PGAR; Fasting-Induced Adipose Factor; ARP4; Angiop
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Cat. No.: HY-P99761
CAS No.: 1690307-05-1
Synonyms: XmAb5871

Target:  

CD19 Apoptosis

Research Areas:  

Inflammation/Immunology

Obexelimab (XmAb5871) is a humanized anti-CD19 antibody. Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus erythematosus .
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Cat. No.: HY-P991055
CAS No.: 2649379-96-2
Synonyms: RG-6234; RO-7425781

Target:  

CD3

Research Areas:  

Inflammation/Immunology

Forimtamig (RG-6324) is a GPRC5DxCD3 T-cell-engaging bispecific antibody. Forimtamig has a 2 + 1 format, comprising two high-affinity GPRC5D binding moieties and one CD3 binder. Forimtamig further features a P329G LALA mutated Fc domain that inhibits Fcγ receptor and C1q binding, yet retains binding to the neonatal Fc receptor. The isotype control for Forimtamig can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P990256

Target:  

CTLA-4

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) is a mouse-derived IgG2a κ type antibody inhibitor targeting to mouse CTLA-4/CD152. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) can be used for the researches of cancer and immunology, such as colon .
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Cat. No.: HY-P990314

Target:  

EGFR

Research Areas:  

Inflammation/Immunology

AFM24 is a bispecific antibody with a TandAb structure expressed in CHO, targeting EGFR&Fc-gamma-RIIIA. AFM24 contains a huIgG1-SCFV heavy chain and a λ light chain, with a predicted molecular weight (MW) of 196.34 kDa. The isotype control for AFM24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P99983

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Mouse IgG1 (D265A) kappa, Isotype Control is a mouse IgG1(D265A)κ isotype control with a D265A mutation and inactivity against mouse Fc gamma receptors (FcγR1, FcγR2, FcγR3, FcγR4) .
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Cat. No.: HY-P990067
CAS No.: 2639688-77-8
Synonyms: ATOR-1017

Target:  

TNF Receptor

Research Areas:  

Cancer

Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart can be used as monotherapy or in combination with anti-PD1 to exert anticancer activity.
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Cat. No.: HY-N16039
CAS No.: 126221-76-9
TAN-1030A is an indolocarbazole alkaloid with macrophage-activating properties. TAN-1030A induces spreading of a murine macrophage cell line, Mm 1, and augmentes the phagocytic activity, Fc gamma receptor expression and β-glucuronidase activity of murine macrophage cell lines, Mm 1 and J774A.1. TAN-1030A can activate macrophage functions in mice .
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Cat. No.: HY-P991610
Synonyms: Sym025

Research Areas:  

Cancer

S-095029 is a humanized IgG1 monoclonal antibody inhibitor targeting NKG2A. S-095029 significantly attenuates Fc-effector functions, inhibits the interaction with its ligand HLA-E, and increases the antibody-dependent cellular cytotoxicity mediated by other Fc-competent mAbs. S-095029 has a potent antitumor activity with enhancement of killing activity and cytokine secretion (IFNγ, TNF-α and CXCL9) of NK and γδ T-cells in co-culture with cancer cells .
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Cat. No.: HY-P991074

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

GMA-161 is a humanized IgG1 antibody that targets Fcγ receptor III (CD16). GMA-161 has the potential for the study of autoimmune disorders. The isotype control for GMA-161 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-D2341
CAS No.: 3055969-34-8
6FC-GABA-Taxol is a fluorescent probe with cell permeability, which is formed by connecting 6FC to the anticancer drug Taxol (HY-B0015) via γ-aminobutyric acid (GABA). 6FC-GABA-Taxol can bind to microtubules in living cells and image them through confocal microscopy. Additionally, 6FC-GABA-Taxol enables the quantification of microtubule binding using flow cytometry without the addition of efflux inhibitors .
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Cat. No.: HY-P991582

Research Areas:  

Cancer

BI-1607 is a humanized monoclonal antibody targeting FcγRIIB/CD32b. BI-1607 selectively blocks inhibitory FcγRIIB signaling, abrogates its inhibitory function, redirects tumor cell-bound antibodies to activating FcγRs, and its modified Fc region prevents the binding of its own Fc segment to FcγRs. BI-1607 reduces αPD-1 trogocytosis, enhances the effector functions of anti-tumor antibodies (including ADCP and ADCC, promotes intratumoral regulatory T cell (Treg) depletion, myeloid cell reprogramming, induction of interferon-γ (IFN-γ) and CXCL10, and increases the number of activated effector CD8 + T cells. BI-1607 can be used in research related to colorectal cancer, HER2-positive advanced solid tumors, HER2-positive locally advanced or metastatic breast cancer, and HER2-positive metastatic gastric cancer .
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Cat. No.: HY-P11340
CAS No.: 202657-61-2
Target:  

MHC

Research Areas:  

Infection Inflammation/Immunology

VMAPRTLFL is a 9-mer peptide derived from the signal peptide of HLA-G and can serve as a peptide ligand for HLA-E. VMAPRTLFL plays a crucial role in regulating the functions of adaptive natural killer (NK) cells. Specifically, VMAPRTLFL enriches FcεRγ - adaptive NK cells, upregulates the expression of CD25, and enhances their proliferative activity, antibody-dependent cellular cytotoxicity (ADCC), and IFN-γ release. VMAPRTLFL can be used in research related to human cytomegalovirus (HCMV) infection, transplant rejection, and pregnancy immunity .
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