3055969-34-8
Chemical Structure
6FC-GABA-Taxol
- CAS No.: 3055969-34-8
- Formula:C61H61FN2O19
- Molecular Weight:1145.14
InChIKey: JTEZFTRLDGHJQM-XOQMUVTQSA-N
SMILES: O=C(N[C@@H](C1=CC=CC=C1)[C@@H](O)C(O[C@@H]2C(C)=C([C@@H](OC(C)=O)C([C@@]3(C)[C@]([C@](OC(C)=O)(CO4)[C@H]4C[C@@H]3OC(CCCNC(C5=CC6=CC(F)=C(O)C=C6OC5=O)=O)=O)([H])[C@@H]7OC(C8=CC=CC=C8)=O)=O)C(C)(C)[C@@]7(O)C2)=O)C9=CC=CC=C9
Biological Activity: 6FC-GABA-Taxol is a fluorescent probe with cell permeability, which is formed by connecting 6FC to the anticancer drug Taxol (HY-B0015) via γ-aminobutyric acid (GABA). 6FC-GABA-Taxol can bind to microtubules in living cells and image them through confocal microscopy. Additionally, 6FC-GABA-Taxol enables the quantification of microtubule binding using flow cytometry without the addition of efflux inhibitors[1].
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6FC-GABA-Taxol | 6FC-GABA-Taxol is a fluorescent probe with cell permeability, which is formed by connecting 6FC to the anticancer drug Taxol (HY-B0015) via γ-aminobutyric acid (GABA). 6FC-GABA-Taxol can bind to microtubules in living cells and image them through confocal microscopy. Additionally, 6FC-GABA-Taxol enables the quantification of microtubule binding using flow cytometry without the addition of efflux inhibitors. | |||||||||||||||||||||
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Keywords
