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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
GHS
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "GHS" in MCE Product Catalog:
3
3 Cited Publications
Referencia número: HY-U00433
No. CAS: 925238-89-7
Target:
Áreas de investigación:
JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.
3
3 Cited Publications
Referencia número: HY-U00433A
No. CAS: 2448414-54-6
Target:
Áreas de investigación:
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
2
2 Cited Publications
Referencia número: HY-19884B
No. CAS: 2863659-22-5
Synonyms: RM-131 TFA; BIM-28131 TFA
Target:
Áreas de investigación:
1
1 Cited Publications
Referencia número: HY-P5645
No. CAS: 1683582-94-6
Synonyms: Human liver expressed antimicrobial peptide-2
Áreas de investigación:
Referencia número: HY-W002199
No. CAS: 647-42-7
Synonyms: 6:2 FTOH; 1H,1H,2H,2H-Perfluoro-1-octanol; 2-(Perfluorohexyl)ethanol
Target:
Áreas de investigación:
6:2 Fluorotelomer alcohol (6:2 FTOH) is an orally active, blood-brain barrier-permeable modulator of cyclin D1 and ETS1. 6:2 Fluorotelomer alcohol downregulates cyclin D1 expression, upregulates ETS1 via the TNF-α/ERK 1/2 pathway, impairs mitochondrial membrane potential and respiratory function, increases reactive oxygen species levels, disrupts calcium homeostasis and activates endoplasmic reticulum stress markers, and induces cell proliferation inhibition and endothelial-mesenchymal transition. Furthermore, 6:2 Fluorotelomer alcohol induces morphological abnormalities in zebrafish embryos and liver developmental damage, while disrupting the brain immune microenvironment in mice, causing systemic toxicity and delayed pup maturation in CD-1 mice. 6:2 Fluorotelomer alcohol also induces cortical neuron apoptosis, glial cell activation, synaptic abnormalities, colonic barrier damage, intestinal dysbiosis and autism spectrum disorder-like symptoms in mice. 6:2 Fluorotelomer alcohol shows no mutagenic, clastogenic, primary skin/eye irritation or skin sensitizing effects, exhibits no selective reproductive toxicity in CD-1 mice, and is classified as GHS Category 4 for acute oral toxicity. 6:2 Fluorotelomer alcohol can be used in studies of neurodevelopmental disorders and autism spectrum disorders .
Target:
Áreas de investigación:
(αR,8aS)-GSK1614343 is the isomer of GSK1614343 (HY-113906). GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors .
Referencia número: HY-P1139
No. CAS: 485803-62-1
Synonyms: PCFWKTCK
Target:
Áreas de investigación:
Referencia número: HY-50760
No. CAS: 145455-35-2
Target:
Áreas de investigación:
L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release .
Referencia número: HY-19884
No. CAS: 661472-41-9
Synonyms: RM-131; BIM-28131
Target:
Áreas de investigación:
Synonyms: MK-0751
Target:
Áreas de investigación:
L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a Ki of 63 nM .
Referencia número: HY-137061
No. CAS: 1143020-91-0
Target:
Áreas de investigación:
AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC50=0.77 nM) .
Referencia número: HY-19884A
No. CAS: 1809080-14-5
Synonyms: RM-131 acetate; BIM-28131 acetate
Target:
Áreas de investigación:
Referencia número: HY-116959
No. CAS: 259667-25-9
Target:
Áreas de investigación:
SM-130686 is an oxindole derivative and an active GH secretagogue (GHS). SM-130686 stimulates GH release with a Half-maximum stimulation of 6.3 nM. SM-130686 has an orally active .
Referencia número: HY-15242
No. CAS: 193273-66-4
Synonyms: CP 424391
Target:
Áreas de investigación:
Capromorelin (CP 424391) is a pyrazolinone-piperidine dipeptide. Capromorelin is an orally active and potent growth hormone secretagogue (GHS) (hGHS-R1a Ki=7 nM, rat pituicyte EC50=3 nM) .
Referencia número: HY-113906
No. CAS: 1092076-04-4
Target:
Áreas de investigación:
GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. GSK1614343 inhibits the calcium response induced by ghrelin with a pIC50 value of 7.90. GSK1614343 represents a useful tool to investigate the physiological relevance of the ghrelin system in rat models .
Referencia número: HY-119125
No. CAS: 295337-71-2
BMS-317180 is an orally active and potent growth hormone secretagogue receptor (GHS-R) agonist (EC50=7.9 nM). BMS-317180 stimulates endogenous growth hormone (GH) release. BMS-317180 is promising for research of age-related frailty, osteoporosis, and cancer cachexia .
Referencia número: HY-129287
No. CAS: 925239-09-4
Target:
Áreas de investigación:
JMV 3008 is a GHS-R1a antagonist with an IC50 of 5.6 nM. JMV 3008 can be used in the research of diseases such as diabetes and obesity .
Referencia número: HY-10957A
No. CAS: 169188-19-6
Synonyms: MK-0751 hydrochloride
Target:
Áreas de investigación:
L-692429 (MK-0751) hydrochloride is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 hydrochloride binds to G protein-coupled receptor with a Ki of 63 nM .
Referencia número: HY-176995
No. CAS: 1143021-16-2
Target:
Áreas de investigación:
AZ-GHS-38 (compound 38) is an orally active CNS-penetrant inverse agonist of growth hormone secretagogue receptor (GHS-R1a) with an IC50 of 6.7 nM. AZ-GHS-38 results in acute reduction of food intake in wild-type mice. AZ-GHS-38 can be used for anti-obesity research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
