485803-62-1
Chemical Structure
Cortistatin-8
Synonym(s): PCFWKTCK
- CAS. Nr.: 485803-62-1
- Formula:C47H68N12O9S2
- Molecular Weight:1009.25
IUPAC Name: (4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-10-(4-aminobutyl)-16-benzyl-N-((S)-1,6-diamino-1-oxohexan-2-yl)-7-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-19-((S)-pyrrolidine-2-carboxamido)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
InChIKey: UHALUVNIZLPZSZ-BPBAYLLVSA-N
SMILES: O=C(N[C@@H]1CC2=CNC3=CC=CC=C23)[C@H](CC4=CC=CC=C4)NC([C@@]([H])(NC([C@@H]5CCCN5)=O)CSSC[C@H](NC([C@@]([H])(NC([C@@]([H])(NC1=O)CCCCN)=O)[C@@H](C)O)=O)C(N[C@@H](CCCCN)C(N)=O)=O)=O
Biological Activity: Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1].
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Cortistatin-8 | 99.56% | Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals. | ||||||||||||||||||||
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