JMV 3008
JMV 3008 is a GHS-R1a antagonist with an IC50 of 5.6 nM. JMV 3008 can be used in the research of diseases such as diabetes and obesity.
For research use only. We do not sell to patients.
- CAS No.: 925239-09-4
- Formula: C36H39N7O3
- Molecular Weight:617.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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GHSR1a 5.6 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
5.6 nM
Compound: 2, JMV 3008
|
Antagonist activity at mouse GSH-R1a receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced calcium mobilization after 5 mins by FLIPR assay
Antagonist activity at mouse GSH-R1a receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced calcium mobilization after 5 mins by FLIPR assay
|
[PMID: 22342626] |
| LLC-PK1 | IC50 |
5.6 nM
Compound: JMV 3008
|
Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells
Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells
|
[PMID: 18193826] |
Chemical Information
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CAS No. 925239-09-4
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Molecular Weight 617.74
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Formula C36H39N7O3
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SMILES
O=C([C@H]1NCCC1)N[C@@H](C2=NN=C(CCC3=CNC4=C3C=CC=C4)N2CC5=CC=C(OC)C=C5OC)CC6=CNC7=C6C=CC=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)