2. GPCR/G Protein
  3. GHSR
  4. BMS-317180

BMS-317180 is an orally active and potent growth hormone secretagogue receptor (GHS-R) agonist (EC50=7.9 nM). BMS-317180 stimulates endogenous growth hormone (GH) release. BMS-317180 is promising for research of age-related frailty, osteoporosis, and cancer cachexia.

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BMS-317180

BMS-317180 Chemical Structure

CAS No. : 295337-71-2

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BMS-317180 Related Antibodies

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GHSR1a

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Description

BMS-317180 is an orally active and potent growth hormone secretagogue receptor (GHS-R) agonist (EC50=7.9 nM). BMS-317180 stimulates endogenous growth hormone (GH) release. BMS-317180 is promising for research of age-related frailty, osteoporosis, and cancer cachexia[1].

Cellular Effect
Cell Line Type Value Description References
H4 EC50
1.9 nM
Compound: 2, BMS-317180
Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay
Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay
[PMID: 17973363]
H4 EC50
1.9 nM
Compound: 4, BMS-317180
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay
[PMID: 18378446]
Molecular Weight

463.53

Formula

C21H33N7O5
CAS No.
SMILES

O=C(NCCCCO)OCCN1N=NN=C1[C@@H](COCC2=CC=CC=C2)NC(C(N)(C)C)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-317180 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-317180295337-71-2BMS317180BMS 317180GHSRGrowth hormone secretagogue receptorGhrelin receptororally activeGHS-Rcancer cachexiaInhibitorinhibitorinhibit

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