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Cat. No.: HY-176995

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AZ-GHS-38

AZ-GHS-38 (compound 38) is an orally active CNS-penetrant inverse agonist of growth hormone secretagogue receptor (GHS-R1a) with an IC₅₀ of 6.7 nM. AZ-GHS-38 results in acute reduction of food intake in wild-type mice. AZ-GHS-38 can be used for anti-obesity research.

For research use only. We do not sell to patients.

CAS No.: 1143021-16-2
Formula: C₂₅H₂₈ClN₅O₅S₂
Molecular Weight:578.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AZ-GHS-38 Chemical Structure

CAS No.: 1143021-16-2

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Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

GHSR1a

6.7 nM (IC₅₀)

All GHSR Isoforms :

GHSR1a

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	39 nM Compound: 38	Displacement of [125I]human ghrelin from mouse GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method Displacement of [125I]human ghrelin from mouse GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	[PMID: 24967667]

Parmacokinetics

Species	Dose	Route	CL	V_ss	C_max	F
Dog^[1]	2 mg/kg	i.v.	10 mL/min/kg	0.4 L/kg	/	/
Dog^[1]	2 mg/kg	p.o.	/	/	1.0 μM	31 %
Mice^[1]	2 mg/kg	i.v.	1.8 mL/min/kg	0.4 L/kg	/	/
Mice^[1]	7 mg/kg	p.o.	/	/	8 μM	25 %

Chemical Information

CAS No. 1143021-16-2
Molecular Weight 578.10
Formula C₂₅H₂₈ClN₅O₅S₂
SMILES

O=C(NC1=NC2=C(S1)C=C(S(=O)(C3CCN(CC3)C)=O)C=C2)NC(C4=CC(N5CCOCC5)=CC=C4Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McCoull W, et al. Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J Med Chem. 2014 Jul 24;57(14):6128-40. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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