4 Results for "

Garcinone C

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "Garcinone C" in MCE Product Catalog:

2
Garcinone C
Garcinone C
0 Images
2 Cited Publications
Cat. No.: HY-N6954
CAS No.: 76996-27-5
Category:  

other families Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

ATM/ATR STAT CDK Hedgehog

Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
loading...
    loading...
View All Sizes
4
Garcinone D
Garcinone D
0 Images
4 Cited Publications
Cat. No.: HY-N6953
CAS No.: 107390-08-9
Category:  

Xanthones Guttiferae Garcinia mangostana Linn. Phenols Polyphenols Plants

Target:  

STAT Keap1-Nrf2 Reactive Oxygen Species (ROS)

Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer .
loading...
    loading...
View All Sizes
Garcinone C (Standard)
Garcinone C (Standard)
0 Images
Cat. No.: HY-N6954R
CAS No.: 76996-27-5
Category:  

other families Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Phenols Polyphenols Plants

Target:  

Reference Standards ATM/ATR STAT CDK Hedgehog

Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
loading...
    loading...
View All Sizes
Garcinone D (Standard)
Garcinone D (Standard)
0 Images
Cat. No.: HY-N6953R
CAS No.: 107390-08-9
Category:  

Xanthones Guttiferae Garcinia mangostana Linn. Phenols Polyphenols Plants

Target:  

Reference Standards STAT Keap1-Nrf2 Reactive Oxygen Species (ROS)

Garcinone D (Standard) is the analytical standard of Garcinone D (HY-N6953). This product is intended for research and analytical applications. Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer .
loading...
    loading...
View All Sizes
Assay Types