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Results for "

HCN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HCN Channel (30) 5-HT Receptor (2) Antibiotic (1) Drug Metabolite (5) Endogenous Metabolite (1) Isotope-Labeled Compounds (2) Phosphatase (1) PKA (1) Potassium Channel (8) Reference Standards (3) Serotonin Transporter (2) Small Interfering RNA (siRNA) (13) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (12) Endocrinology (1) Infection (2) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (27)
Oligonucleotides:	Rat Pre-designed siRNA Sets (4) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (5) siRNAs (13)

Inhibitors & Agonists

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: HCN Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0162A

Ivabradine hydrochloride 3 Publications Verification	HCN Channel	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Cancer
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-101346

ZD7288 Maximum Cited Publications 9 Publications Verification ICI D7288	HCN Channel	Neurological Disease
ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker .

HY-N6789

KT5720 4 Publications Verification	PKA	Neurological Disease Cancer
KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC₅₀=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 ⁺ concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases .

HY-W052508

Norquetiapine 1 Publications Verification N-Desalkylquetiapine	Drug Metabolite 5-HT Receptor HCN Channel Serotonin Transporter	Neurological Disease
Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

HY-18940A

Cilobradine hydrochloride DK-AH 269	HCN Channel	Cardiovascular Disease Neurological Disease
Cilobradine hydrochloride is a *HCN* channel blocker. Cilobradine hydrochloride induces cardiac pacemaker currents and produces antidepressant effects .

HY-B0162

Ivabradine 3 Publications Verification	HCN Channel	Cardiovascular Disease Cancer
Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-160505

RO-275	HCN Channel	Neurological Disease
RO-275 (compound 29) is a potent, selective and orally active *HCN1* inhibitor with IC₅₀ values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder .

HY-13422

Zatebradine hydrochloride 2 Publications Verification UL-FS-49; UL-FS-49CL	HCN Channel	Cardiovascular Disease
Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of *hyperpolarization-activated cyclic nucleotide-gated (HCN) channels* with an IC₅₀ values 1.96 µM. Zatebradine blocks the slow inward current through human *HCN1, HCN2, HCN3* and HCN4 channels, with IC₅₀ values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively .

HY-172550

MS7710	HCN Channel	Neurological Disease
MS7710 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel inhibitor with blood-brain barrier permeability and an excellent brain/plasma concentration ratio. MS7710 inhibits *HCN* channel-mediated I_h current, and reduces the firing frequency and burst activity of dopaminergic neurons in the ventral tegmental area. MS7710 ameliorates chronic social defeat stress-induced deficits in social interaction and impairments in reward-related cognitive flexibility in mice. MS7710 exerts only limited effects on ventral tegmental area dopaminergic neuron activity, social interaction, exploratory behavior, locomotor activity or sucrose preference in control mice. MS7710 is applicable to the research of major depressive disorder .

HY-163455

*pan-HCN-IN-1*	HCN Channel	Neurological Disease
pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC₅₀ of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices .

HY-13422A

Zatebradine 2 Publications Verification UL-FS-49 free base; UL-FS-49CL free base	HCN Channel	Cardiovascular Disease
Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of *hyperpolarization-activated cyclic nucleotide-gated (HCN) channels* with an IC₅₀ value of 1.96 µM. Zatebradine blocks the slow inward current through human *HCN1, HCN2, HCN3* and HCN4 channels, with IC₅₀ values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively .

HY-108574

CP 339818 hydrochloride	Potassium Channel HCN Channel	Neurological Disease
CP 339818 hydrochloride is a non-peptide Kv1.3 channel (IC₅₀ = 200 nM) and Kv1.4 channel blocker. CP 339818 hydrochloride inhibits HCN channel with IC₅₀s of 18.9 μM and 43.4 μM against *HCN1* and *HCN4* (high Cl ^-). CP 339818 hydrochloride has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP 339818 hydrochloride selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP 339818 hydrochloride can be used to study the physiological functions of HCN and Kv channels .

HY-161092

KIO-301 chloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light .

HY-161092A

KIO-301 chloride hydrochloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .

HY-RS16342

MALAT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MALAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for MALAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MALAT1 Human Pre-designed siRNA Set A MALAT1 Human Pre-designed siRNA Set A

HY-W052508S

Norquetiapine-d8 N-Desalkylquetiapine-d₈	Isotope-Labeled Compounds	Others Neurological Disease Inflammation/Immunology
Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

HY-160209

KIO-301	HCN Channel	Cardiovascular Disease
KIO-301 is a photoswitchable HCN channel blocker, and can be used as the vitreous “light switch” molecule that reactivates retinitis pigmentosa .

HY-W040555

Norquetiapine dihydrochloride 1 Publications Verification N-Desalkylquetiapine dihydrochloride	Drug Metabolite 5-HT Receptor HCN Channel Serotonin Transporter	Neurological Disease
Norquetiapine ( N-Desalkylauetiapine) dihydrochloride, a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine dihydrochloride selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine dihydrochloride blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine dihydrochloride shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine dihydrochloride can be used for the study of depression and inflammation .

HY-119102

BPU-11	HCN Channel	Inflammation/Immunology
BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease .

HY-RS06048

HCN3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN3 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN3 Human Pre-designed siRNA Set A HCN3 Human Pre-designed siRNA Set A

HY-RS25103

Hcn2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn2 Rat Pre-designed siRNA Set A Hcn2 Rat Pre-designed siRNA Set A

HY-RS06046

HCN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN1 Human Pre-designed siRNA Set A HCN1 Human Pre-designed siRNA Set A

HY-RS06047

HCN2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN2 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN2 Human Pre-designed siRNA Set A HCN2 Human Pre-designed siRNA Set A

HY-RS18617

Hcn2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn2 Mouse Pre-designed siRNA Set A Hcn2 Mouse Pre-designed siRNA Set A

HY-RS26794

Hcn4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn4 Rat Pre-designed siRNA Set A Hcn4 Rat Pre-designed siRNA Set A

HY-RS06049

HCN4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HCN4 Human Pre-designed siRNA Set A contains three designed siRNAs for HCN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HCN4 Human Pre-designed siRNA Set A HCN4 Human Pre-designed siRNA Set A

HY-RS22198

Hcn1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn1 Mouse Pre-designed siRNA Set A Hcn1 Mouse Pre-designed siRNA Set A

HY-RS19140

Hcn3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn3 Mouse Pre-designed siRNA Set A Hcn3 Mouse Pre-designed siRNA Set A

HY-13422R

Zatebradine hydrochloride (Standard) UL-FS-49 (Standard); UL-FS-49CL (Standard)	HCN Channel Reference Standards	Cardiovascular Disease
Zatebradine (hydrochloride) (Standard) is the analytical standard of Zatebradine (hydrochloride). This product is intended for research and analytical applications. Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 μM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively .

HY-18940

Cilobradine Cilo	Endogenous Metabolite	Cardiovascular Disease
Cilobradine (Cilo) is a HCN channel blocker with heart rate reducing activity. Cilobradine blocks the slow inward current of human HCN1, HCN2, HCN3, and HCN4 channels. Cilobradine has a slightly higher efficiency in blocking endogenous If in mouse sinoatrial node cells (IC50 value is 0.62μM). Cilobradine can dose-dependently reduce the heart rate from 600 to 200 bpm with an ED50 value of 1.2 mg/kg. Cilobradine induces arrhythmias at doses greater than 5 mg/kg, which are characterized by periodic fluctuations between T waves and P waves .

HY-186062

HCN-IN-1	Toll-like Receptor (TLR) Potassium Channel Phosphatase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
HCN-IN-1 is a TLR4 inhibitor and HCN channel modulator with activity against *HCN2* and *HCN4*.HCN-IN-1 inhibits TLR4-mediated alkaline phosphatase (SEAP) signal activity.HCN-IN-1 reduces *HCN2* current across tested voltages, shifts voltage-dependent activation to more hyperpolarized potentials, slows activation kinetics, and does not affect deactivation process.HCN-IN-1 blocks *HCN4* current.HCN-IN-1 exhibits analgesic, anti-inflammatory, and anti-anginal effects.HCN-IN-1 can be used for the research of inflammatory pain, neuropathic pain, heart failure, inflammation .

HY-114540

CP-339818	Potassium Channel HCN Channel	Neurological Disease
CP-339818 is a non-peptide Kv1.3 channel (IC₅₀ = 200 nM) and Kv1.4 channel blocker. CP 339818 inhibits HCN channel with IC₅₀s of 18.9 μM and 43.4 μM against *HCN1* and *HCN4* (high Cl ^-). CP-339818 has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP-339818 selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP-339818 can be used to study the physiological functions of HCN and Kv channels .

HY-131281

Ivabradine impurity 1	Drug Metabolite	Others
Ivabradine impurity 1 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-131282

Ivabradine impurity 2	Drug Metabolite	Others
Ivabradine impurity 2 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-131283

8-Demethyl Ivabradine	Drug Metabolite	Endocrinology
8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-B0162S

Ivabradine-d6	Isotope-Labeled Compounds HCN Channel	Cardiovascular Disease
Ivabradine-d₆ is the deuterium labeled Ivabradine . Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162AR

Ivabradine hydrochloride (Standard)	Reference Standards HCN Channel	Cardiovascular Disease Metabolic Disease Cancer
Ivabradine hydrochloride (Standard) is the analytical standard of Ivabradine hydrochloride. This product is intended for research and analytical applications. Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-186058

HCN2-IN-6	HCN Channel	Neurological Disease Inflammation/Immunology
HCN2-IN-6 is a *HCN2* ion channel inhibitor with an IC₅₀ of 7 nM. HCN2-IN-6 shows weak inhibitory activity for HCN4. HCN2-IN-6 can be used for the research of inflammatory disease and neurological disorders .

HY-186057

HCN2-IN-5	HCN Channel
HCN2-IN-5 is a *HCN2* ion channel inhibitor with an IC₅₀ of 9 nM. HCN2-IN-5 shows weak inhibitory activity for HCN4. HCN2-IN-5 can be used for the research of inflammatory disease and neurological disorders .

HY-186056

HCN2-IN-3	HCN Channel	Neurological Disease
HCN2-IN-3 is an orally active *HCN2* inhibitor. HCN2-IN-3 inhibits the activity of *HCN2* ion channels. HCN2-IN-3 is applicable to research related to pain, tinnitus, central nervous system diseases, mental illnesses and mood disorders .

HY-186061

HCN2-IN-4	HCN Channel	Neurological Disease
HCN2-IN-4 is an orally active *HCN2* ion channel inhibitor, with an IC₅₀ of 3 nM. HCN2-IN-4 inhibits the activity of *HCN2* ion channels. HCN2-IN-4 can be used in the research of pain, tinnitus and central nervous system diseases .

HY-186066

HCN2-IN-2	HCN Channel	Neurological Disease
HCN2-IN-2 (Compound 35), azaindazole derivative, is a selective *HCN2* inhibitor with an IC₅₀ of 145 nM. HCN2-IN-2 inhibits HCN2 channel activity blocks abnormal firing of peripheral nociceptive neurons. HCN2-IN-2 can be used for the research of pain .

HY-186065

HCN2-IN-1	HCN Channel	Neurological Disease
HCN2-IN-1 (compound 32) is a *HCN2* inhibitor with the IC₅₀ of 98 nM. HCN2-IN-1 can be used for the research of central nervous system (CNS) and psychiatric disorders .

HY-114735

Mandelonitrile benzoate	Antibiotic	Infection
Mandelonitrile benzoate is a defensive secretion of millipedes that releases other chemicals during the cyanidation process in addition to hydrocyanic acid (HCN) and benzaldehyde. Several families of millipedes, including Polydesmidae, Paradoxosomatidae, and Euryuridae, have been shown to secrete phenols and guaiaeol, with one Paradoxosomatid also producing ethylbenzoic acid and benzoic acid. In addition, members of the Xystodesmidae family commonly produce three compounds: benzoic acid, mandelonitrile benzoate, and benzoyl cyanide. Benzoyl cyanide has not been previously discovered as a natural product. These additional natural products are discussed as defensive antipredator and antibiotic agents. Benzoyl cyanide appears to have anesthetic properties for some predators. The study provides a preliminary chemotaxonomic basis for distinguishing various taxonomic groups of millipedes.

HY-186059

HCN2 modulator-4	Potassium Channel	Neurological Disease
HCN2 modulator-4 is a *HCN2* ion channel inhibitor. HCN2 modulator-4 inhibits *HCN2* ion channel activity. HCN2 modulator-4 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .

HY-186059A

HCN2 modulator-5	Potassium Channel	Neurological Disease
HCN2 modulator-5 (S-configuration 39) is a *HCN2* ion channel inhibitor. HCN2 modulator-5 inhibits *HCN2* ion channel activity. HCN2 modulator-5 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .

HY-186060

HCN2 modulator-6	HCN Channel	Neurological Disease
HCN2 modulator-6 is a *HCN2* ion channel inhibitor has an IC₅₀ of 7 nM. HCN2 modulator-6 inhibits *HCN2* ion channel activity. HCN2 modulator-6 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .

HY-186061A

HCN2 modulator-8	Potassium Channel	Neurological Disease
HCN2 modulator-8 is a pyrazolopyridine derivative and selective *HCN2* inhibitor. HCN2 modulator-8 can be used for the research of pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders .

HY-RS25631

Hcn3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcn3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn3 Rat Pre-designed siRNA Set A Hcn3 Rat Pre-designed siRNA Set A

HY-RS20286

Hcn4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hcn4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcn4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hcn4 Mouse Pre-designed siRNA Set A Hcn4 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Chemical Structure

HY-W052508S

Norquetiapine-d8

Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

HY-B0162S

Ivabradine-d6
Ivabradine-d₆ is the deuterium labeled Ivabradine . Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

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