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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
HNF4α
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "HNF4α" in MCE Product Catalog:
14
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14
14 Publications Verification
Cat. No.: HY-P0082A
CAS No.: 28270-04-4
Synonyms: Glucagon hydrochloride
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Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
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5 Cited Publications
Cat. No.: HY-108469
CAS No.: 93987-29-2
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BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes .
Cat. No.: HY-176136
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HNF4 agonist 1 is a HNF4 agonist. HNF4 agonist 1 activates HNF4α and HNF4γ with EC50 values of 6 nM and 17 nM, respectively. HNF4 agonist 1 can be used in studies related to maturity-onset diabetes of the young type 1 (mody-1) .
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DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity .
Cat. No.: HY-B1058A
CAS No.: 23602-78-0
Synonyms: JP-992
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Benfluorex (JP-992) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
Cat. No.: HY-119971
CAS No.: 337506-43-1
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BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes .
Cat. No.: HY-B1058R
CAS No.: 23642-66-2
Synonyms: JP-992 hydrochloride (Standard)
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Benfluorex (hydrochloride) (Standard) is the analytical standard of Benfluorex (hydrochloride). This product is intended for research and analytical applications. Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
Cat. No.: HY-108469R
CAS No.: 93987-29-2
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BI-6015 (Standard) is the analytical standard of BI-6015 (HY-108469). This product is intended for research and analytical applications. BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes .
Cat. No.: HY-18314B
CAS No.: 504433-24-3
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(Z)-GW 441756 is a hepatocyte nuclear factor 4α (HNF4α) activator, with an EC50 of 9.2 μM and a Ka of 4.6 μM in human systems. (Z)-GW 441756 directly interacts with the ligand-binding domain of HNF4α via persistent hydrogen bonds and hydrophobic interactions within the binding pocket. (Z)-GW 441756 reduces the accumulation of triglycerides and total cholesterol. (Z)-GW 441756 inhibits ferroptosis through a non-antioxidant mechanism. (Z)-GW 441756 decreases plasma triglyceride and total cholesterol levels in animal models of hyperlipidemia. (Z)-GW 441756 can be used in studies related to hyperlipidemia .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
