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IKZF Family

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標的別:	IKZF Family (3) Apoptosis (1) E1/E2/E3 Enzyme (1) Epigenetic Reader Domain (1) HDAC (1) Histone Acetyltransferase (1) Molecular Glues (2) PROTACs (1)
研究分野別:	Cancer (4) Infection (1)

阻害剤およびアゴニスト

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Targets Recommended: IKZF Family

製品番号	製品名	Target	研究分野	構造式

HY-177758

PROTAC HDAC6 degrader 8	PROTACs HDAC	Cancer
HDAC6 degrader-6 (Compound 11b) is a potent and selective HDAC6 PROTAC degrader with a DC₅₀ of 1.9 nM. HDAC6 degrader-6 has no effect on the protein levels of other HDAC family members and does not degrade IKZF1, IKZF3, and GSPT1. HDAC6 degrader-6 can be used to study multiple myeloma (Pink: HDAC6 ligand (HY-177776); Blue: CRBN ligand (HY-W998281); Black: Linker) .

HY-170518

IKZF-IN-1	IKZF Family Molecular Glues	Infection Cancer
IKZF-IN-1 (Compound I) is the molecular glue, that degrades ikaros zinc finger family (IKZF) IKZF 1/2/3/4, and can be used as an immunomodulator in research of cancer and viral infections .

HY-182467

BMS-986482	Molecular Glues IKZF Family E1/E2/E3 Enzyme	Cancer
BMS-986482 is a CELMoD, CRBN-mediated, selective *IKZF1-4* Molecular Glue degrader. The activity of BMS-986482 is driven by a non-traditional CELMoD core that selectively degrades the IKZF protein family. BMS-986482 inhibits tumor growth in preclinical mouse models. BMS-986482 can be used for the research of advanced solid tumors . .

HY-181957

KB528	Epigenetic Reader Domain Histone Acetyltransferase Apoptosis IKZF Family	Cancer
KB528 is a p300/CBP histone acetyltransferase (KAT) inhibitor with low nM IC₅₀ values against human p300 and CBP, and exhibits selectivity over other KAT family members. KB528 modulates the IRF4 transcriptional network, downregulates the expression of IRF4, MYC, CAV2 and IGLL5, and reduces the protein level of *IKZF3. KB528 potently induces apoptosis* in multiple myeloma cells. KB528 is applicable to research related to multiple myeloma .

Host:	Mouse (3) Rabbit (3)
Reactivity:	Human (6) Rat (1) Mouse (2) Dog (1)
Application:	IHC-P (3) ICC/IF (1) IP (2) WB (4) FC (1)
Isotype:	IgG (3) IgG1 (1)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (5) Recombinant (2)
Modification:	Unmodified (5)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P82371

	IKZF3 Antibody (YA2116) IKZF3; ZNFN1A3; Zinc finger protein Aiolos; Ikaros Family zinc finger protein 3	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	IKZF3 Antibody (YA2116) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKZF3.

HY-P85438

	Ikaros Antibody (YA5130) IKZF1; IK1; IKAROS; LYF1; ZNFN1A1; DNA-binding protein Ikaros; Ikaros Family zinc finger protein 1; Lymphoid transcription factor LyF-1	WB	Human, Mouse, Dog
	Ikaros Antibody (YA5130) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ikaros.

HY-P81282

	Ikaros Antibody (YA987) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zinc finger protein); IKAROS; IKAROS Family zinc finger 1 (Ikaros); Ikaros Family zinc finger protein 1; IKZF1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subFamily 1A 1 (Ikaros); zinc finger protein subFamily 1A 1; Zinc finger protein; subFamily 1A; member 1; ZNFN1A1.	WB, IP	Human
	Ikaros Antibody (YA987) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ikaros.

HY-P81282A

	Ikaros Antibody (YA988) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zinc finger protein); IKAROS; IKAROS Family zinc finger 1 (Ikaros); Ikaros Family zinc finger protein 1; IKZF1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subFamily 1A 1 (Ikaros); zinc finger protein subFamily 1A 1; Zinc finger protein; subFamily 1A; member 1; ZNFN1A1.	IHC-P	Human
	Ikaros Antibody (YA988) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ikaros.

HY-P85524

	Ikaros(C-term) Antibody (YA5216) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros; zinc finger protein; IKAROS; IKAROS Family zinc finger 1; Ikaros; Ikaros Family zinc finger protein 1; IKZF1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subFamily 1A 1; Ikaros; zinc finger protein subFamily 1A 1; Zinc finger protein, subFamily 1A, member 1; ZNFN1A1.	WB, IP	Human
	Ikaros(C-term) Antibody (YA5216) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ikaros(C-term).

HY-P81282AA

	Ikaros Antibody (YA988)(PBS only) CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zinc finger protein); IKAROS; IKAROS Family zinc finger 1 (Ikaros); Ikaros Family zinc finger protein 1; IKZF1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subFamily 1A 1 (Ikaros); zinc finger protein subFamily 1A 1; Zinc finger protein; subFamily 1A; member 1; ZNFN1A1.	IHC-P	Human
	Ikaros Antibody (YA988) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ikaros.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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