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Cat. No.: HY-177758

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PROTAC HDAC6 degrader 8

PROTAC HDAC6 degrader 8 is a potent and selective HDAC6 PROTAC degrader with a DC₅₀ of 1.94 nM. PROTAC HDAC6 degrader 8 induces HDAC6 degradation in cancer cells with a hook effect, and exerts no impact on other HDAC subtypes, IKZF1, IKZF3 or GSPT1. PROTAC HDAC6 degrader 8 can be used in studies related to multiple myeloma.
(Pink: HDAC6 ligand (HY-177776); Blue: Cereblon ligand (HY-W998281); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₃H₃₇N₅O₇
분자량:615.68

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PROTAC HDAC6 degrader 8 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PROTAC HDAC6 degrader 8 is a potent and selective HDAC6 PROTAC degrader with a DC₅₀ of 1.94 nM. PROTAC HDAC6 degrader 8 induces HDAC6 degradation in cancer cells with a hook effect, and exerts no impact on other HDAC subtypes, IKZF1, IKZF3 or GSPT1. PROTAC HDAC6 degrader 8 can be used in studies related to multiple myeloma^[1]. (Pink: HDAC6 ligand (HY-177776); Blue: Cereblon ligand (HY-W998281); Black: linker).

IC₅₀ & Target

^[1]

HDAC6

1.94 nM (DC₅₀)

Cereblon

All PROTACs Isoforms :

All HDAC Isoforms :

In Vitro

Anti-cancer

PROTAC HDAC6 degrader 8 (Compound 11b) (0.1 nM-3 μM; 6 h) selectively degrades HDAC6 in MM1S cells with a DC₅₀ of 1.94 nM, without affecting other HDAC isoforms or the CRBN neo-substrates IKZF1, IKZF3 and GSPT1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MM1S human multiple myeloma cells
Concentration:

0.1 nM, 0.3 nM, 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 300 nM, 1 μM, 3 μM
Incubation Time:

6 h
Result:

Selectively degraded HDAC6, with no significant effect on the expression of HDAC1, HDAC2, HDAC4, HDAC8, IKZF1, IKZF3, or GSPT1.
Caused significant HDAC6 degradation at concentrations as low as 3 nM, with a hook effect noted around 300 nM.

Chemical Information

분자량 615.68
화학식 C₃₃H₃₇N₅O₇
SMILES

O=C(CCCCCCC(N/N=C/C1=CC=C(C=C1)OCCCC#CC2=CC=CC3=C2CN(C3=O)C(C(N4)=O)CCC4=O)=O)NO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang K, et al. A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders. Cell chemical biology. 2020 Jul 16;27(7):866-876.e8. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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