PROTAC HDAC6 degrader 8
PROTAC HDAC6 degrader 8 is a potent and selective HDAC6 PROTAC degrader with a DC50 of 1.94 nM. PROTAC HDAC6 degrader 8 induces HDAC6 degradation in cancer cells with a hook effect, and exerts no impact on other HDAC subtypes, IKZF1, IKZF3 or GSPT1. PROTAC HDAC6 degrader 8 can be used in studies related to multiple myeloma.
(Pink: HDAC6 ligand (HY-177776); Blue: Cereblon ligand (HY-W998281); Black: linker).
For research use only. We do not sell to patients.
- Formula: C33H37N5O7
- Molecular Weight:615.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
HDAC6 1.94 nM (DC50) |
Cereblon |
In Vitro
PROTAC HDAC6 degrader 8 (Compound 11b) (0.1 nM-3 μM; 6 h) selectively degrades HDAC6 in MM1S cells with a DC50 of 1.94 nM, without affecting other HDAC isoforms or the CRBN neo-substrates IKZF1, IKZF3 and GSPT1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MM1S human multiple myeloma cells
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Concentration:0.1 nM, 0.3 nM, 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 300 nM, 1 μM, 3 μM
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Incubation Time:6 h
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Result:Selectively degraded HDAC6, with no significant effect on the expression of HDAC1, HDAC2, HDAC4, HDAC8, IKZF1, IKZF3, or GSPT1.
Caused significant HDAC6 degradation at concentrations as low as 3 nM, with a hook effect noted around 300 nM.
Chemical Information
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Molecular Weight 615.68
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Formula C33H37N5O7
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SMILES
O=C(CCCCCCC(N/N=C/C1=CC=C(C=C1)OCCCC#CC2=CC=CC3=C2CN(C3=O)C(C(N4)=O)CCC4=O)=O)NO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC HDAC6 degrader 8 Related Classifications
HY-177758 Related Classifications
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