HDAC-IN-97
HDAC-IN-97 is a PROTAC HDAC6 degrader-6that can be used for synthesis of PROTACs, such as HDAC6 degrader-6 (HY-177758). HDAC6 degrader-6 is a potent HDAC6 PROTAC degrader with anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 149647-86-9
- Formula: C8H15NO4
- Molecular Weight:189.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
HDAC6 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | EC50 |
>100 μM
Compound: 1u
|
Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay
|
[PMID: 20218673] |
| HT-29 | EC50 |
>100 μM
Compound: 1u
|
Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay
|
[PMID: 20218673] |
| Jurkat | EC50 |
>100 μM
Compound: 1u
|
Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay
|
[PMID: 20218673] |
| K562 | EC50 |
>100 μM
Compound: 1u
|
Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay
|
[PMID: 20218673] |
| SK-BR-3 | EC50 |
>100 μM
Compound: 1u
|
Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay
|
[PMID: 20218673] |
| U-937 | EC50 |
>100 μM
Compound: 1u
|
Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay
|
[PMID: 20218673] |
Chemical Information
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CAS No. 149647-86-9
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Molecular Weight 189.21
-
Formula C8H15NO4
-
SMILES
O=C(CCCCCCC(O)=O)NO
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)