59 Results for "

IgA

" in MedChemExpress (MCE) Product Catalog:
Products (59)

59 Results for "IgA" in MCE Product Catalog:

31
31 Publications Verification
Cat. No.: HY-113134
CAS No.: 2140-46-7
Purity:  99.98%
Synonyms: 25-OHC
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
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4
4 Cited Publications
Cat. No.: HY-N6712
CAS No.: 87-11-6
Synonyms: Acetopyrrothin
Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC) [1][2][3][4][5].
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2
2 Cited Publications
Cat. No.: HY-116815
CAS No.: 501104-16-1
Purity:  99.75%
Research Areas:  

Infection Neurological Disease

Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease .
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2
2 Cited Publications
Cat. No.: HY-139588
CAS No.: 2086178-00-7
Purity:  98.61%
Synonyms: ALXN2050; ACH 0145228; ACH-5228
Vemircopan (ALXN2050) is an orally active complement factor D (FD) inhibitor. Vemircopan can be used in the research of diseases such as myasthenia gravis, lupus nephritis, IgA nephropathy, and paroxysmal nocturnal hemoglobinuria .
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Cat. No.: HY-P99901
CAS No.: 2382896-07-1
Synonyms: VIS649

Target:  

SARS-CoV

Research Areas:  

Inflammation/Immunology Cancer

Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN) .
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Cat. No.: HY-P990070
CAS No.: 2642175-46-8
Synonyms: BION-1301

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Zigakibart (BION-1301) is an IgG4-kappa, humanized monoclonal antibody against TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256). Zigakibart exhibits anti-inflammatory activity .
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Cat. No.: HY-160719
NHS-activated 2-octynoic acid-BSA is an immunogen used to establish a mouse model of primary biliary cholangitis (PBC). When used in combination with Complete Freund's Adjuvant (HY-153808), NHS-activated 2-octynoic acid-BSA stimulates the body's immune system, which recognizes it as a foreign antigen and triggers an immune response against autologous biliary epithelial cells. This leads to the production of anti-PDC-E2 antibodies, causing bile duct damage and inflammation. NHS-activated 2-octynoic acid-BSA is promising for use in primary biliary cholangitis research .
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Cat. No.: HY-P99638
CAS No.: 2456407-94-4
Synonyms: ALXN-1720

Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Gefurulimab (ALXN-1720) is a high-affinity antibody inhibitor targeting complement protein C5, which can specifically bind to C5 and inhibit its cleavage into C5a and C5b. Gefurulimab can block the activation of the terminal complement pathway and reduce inflammatory damage. Gefurulimab can effectively reduce the formation of membrane attack complex (MAC) and has good pharmacokinetic properties. Gefurulimab can be used to study kidney and autoimmune diseases related to abnormal activation of the complement system, such as IgA nephropathy, lupus nephritis, and myasthenia gravis .
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Cat. No.: HY-N11630
CAS No.: 97134-11-7
Pinellic acid is an orally active adjuvant for intranasal influenza vaccines. Pinellic acid can be extracted from the tubers of Pinellia ternata Breitenbach. When administered intranasally in combination with influenza HA vaccine, Pinellic acid slightly increases the titers of antiviral IgG antibodies in bronchoalveolar lavage fluid and serum. Pinellic acid shows no hemolytic activity. Pinellic acid can be used in studies related to influenza virus infection .
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Cat. No.: HY-P991312

Target:  

Ser/Thr Protease

Research Areas:  

Metabolic Disease

CM-338 is a human monoclonal antibody (mAb) targeting MASP2. CM-338 can be used in IgA nephropathy research.
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Cat. No.: HY-113134S
CAS No.: 88247-69-2
Purity:  ≥99.0%
Synonyms: 25-OHC-d6
25-Hydroxycholesterol-d6 (25-OHC-d6) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells .
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Cat. No.: HY-P5309
CAS No.: 3075785-28-0
Research Areas:  

Inflammation/Immunology

IgA1 Peptide GN5 is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .
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Cat. No.: HY-P5309A
Research Areas:  

Inflammation/Immunology

IgA1 Peptide GN5 (TFA) is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .
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Cat. No.: HY-P5310
Research Areas:  

Others

IgA1 Peptide HP is an IgA1 hinge region peptide .
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Cat. No.: HY-P991538

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

VIS954 is an anti-APRIL monoclonal antibody. VIS954 can be studied in research for anti-neutrophil cytoplasmic antibody-associated vasculitis (ANCA Vasculitis) and IgA nephrophathy .
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Cat. No.: HY-P11422
Target:  

Peptides

Research Areas:  

Infection

CKS9 is an M cell-targeting polypeptide with the amino acid sequence CKSTHPLSC, forming a 9-mer peptide via cyclization through a disulfide bond between the two cysteine residues. CKS9 is obtained through phage display technology screening and has high affinity for M cells. CKS9 can promote chitosan nanoparticles to cross M cells and enter the follicle-associated epithelium (FAE) of intestinal Peyer's patches (PP). CKS9 can be used in studies related to swine dysentery and oral delivery .
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Cat. No.: HY-RS02267
Research Areas:  

Others

CD79A Human Pre-designed siRNA Set A contains three designed siRNAs for CD79A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS17824
Research Areas:  

Others

Cd79a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd79a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-113134R
CAS No.: 2140-46-7
Synonyms: 25-OHC (Standard)
25-Hydroxycholesterol (Standard) is the analytical standard of 25-Hydroxycholesterol. This product is intended for research and analytical applications. 25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
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Cat. No.: HY-N6712R
CAS No.: 87-11-6
Synonyms: Acetopyrrothin (Standard)
Thromycin (Standard) is the analytical standard of thromycin (Acetopyrrothin) (HY-N6712). Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin (HY-15142A)-induced cardiotoxicity (DOXIC) [1][2][3][4][5].
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