97134-11-7
Chemical Structure
Pinellic acid
- CAS No.: 97134-11-7
- Formula:C18H34O5
- Molecular Weight:330.46
IUPAC Name: (9S,12S,13S,E)-9,12,13-trihydroxyoctadec-10-enoic acid
InChIKey: MDIUMSLCYIJBQC-MVFSOIOZSA-N
SMILES: CCCCC[C@H](O)[C@@H](O)/C=C/[C@@H](O)CCCCCCCC(O)=O
Biological Activity: Pinellic acid is an orally active adjuvant for intranasal influenza vaccines. Pinellic acid can be extracted from the tubers of Pinellia ternata Breitenbach. When administered intranasally in combination with influenza HA vaccine, Pinellic acid slightly increases the titers of antiviral IgG antibodies in bronchoalveolar lavage fluid and serum. Pinellic acid shows no hemolytic activity. Pinellic acid can be used in studies related to influenza virus infection[1][2].
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Pinellic acid | Pinellic acid is an orally active adjuvant for intranasal influenza vaccines. Pinellic acid can be extracted from the tubers of Pinellia ternata Breitenbach. When administered intranasally in combination with influenza HA vaccine, Pinellic acid slightly increases the titers of antiviral IgG antibodies in bronchoalveolar lavage fluid and serum. Pinellic acid shows no hemolytic activity. Pinellic acid can be used in studies related to influenza virus infection. | |||||||||||||||||||||
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Similarity Score 1.00
HY-1455439(S)10(S)13(S)-TriHOME -
Similarity Score 1.00
HY-1697459,12,13-Trihydroxy-10-octadecenoic acid -
Similarity Score 1.00
HY-N17783rel-Sanleng acid -
Similarity Score 1.00
HY-N17783ASanleng acid -
Similarity Score 0.88
HY-1651307(S),10(S)-DiHOME -
Similarity Score 0.87
HY-16591211(R),12(S),13(S)-Trihydroxy-9(Z)-octadecenoic acid -
Similarity Score 0.87
HY-1661899(S),10(S),11(R)-Trihydroxy-12(Z)-octadecenoic acid -
Similarity Score 0.87
HY-1661959(S),10(S),13(S)-Trihydroxy-11(E),15(Z)-octadecadienoic acid -
Similarity Score 0.86
HY-1661969,12,13-Trihydroxy-10,15-octadecadienoic acid -
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References
- [1]. Sunazuka T, et al. Total synthesis of pinellic acid, a potent oral adjuvant for nasal influenza vaccine. Determination of the relative and absolute configuration[J]. Tetrahedron Letters, 2002, 43(7): 1265-1268.
- [2]. Nagai T, et al. Pinellic acid from the tuber of Pinellia ternata Breitenbach as an effective oral adjuvant for nasal influenza vaccine. Int Immunopharmacol. 2002;2(8):1183-1193. [Content Brief]
