3 Results for "

JNK-c-Jun pathway

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "JNK-c-Jun pathway" in MCE Product Catalog:

Methyl protodioscin
Methyl protodioscin
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Cat. No.: HY-N0863
CAS No.: 54522-52-0
Synonyms: NSC-698790; Smilax saponin B
Category:  

other families Plants Disease Research Fields Cancer Steroids

Target:  

Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO

Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the Akt1/c-Myc axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing FOXO1 to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis .
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Ophiopogonin B
Ophiopogonin B
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Cat. No.: HY-N1961
CAS No.: 38971-41-4
Synonyms: OP-B
Category:  

Other Terpenoids Terpenoids Plants Disease Research Fields Cancer Asparagaceae Juss.

Target:  

JNK Apoptosis

Ophiopogonin B (OP-B) induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus .
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SGP8
SGP8
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Cat. No.: HY-P6177
CAS No.: 855790-98-6
Target:  

Dipeptidyl Peptidase

Research Areas:  

Inflammation/Immunology

SGP8 (IAVPGEVA) is an octapeptide produced by hydrolysis of soybean 11S globulin, which has the effects of regulating lipid metabolism, inflammation and fibrosis. SGP8 (IAVPGEVA) exhibits inhibitory activity against DPP4 and inhibits the JNK-c-Jun signaling pathway, and has the ability to inhibit non-alcoholic steatohepatitis (NASH) .
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