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Results for "

LKB1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (19) Amyloid-β (3) Apoptosis (3) Bacterial (11) CaMK (1) Caspase (1) Cholinesterase (ChE) (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Insulin Receptor (1) Isotope-Labeled Compounds (8) Keap1-Nrf2 (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) mTOR (1) NF-κB (2) NO Synthase (1) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (3) Parasite (11) Pim (3) Platelet-activating Factor Receptor (PAFR) (1) PPAR (11) Pyk2 (1) Reference Standards (3) Ser/Thr Kinase (1) Small Interfering RNA (siRNA) (3) Survivin (1) Topoisomerase (1) β-catenin (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (12) Inflammation/Immunology (6) Metabolic Disease (15) Neurological Disease (15)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10371

Pim1/AKK1-IN-1 Maximum Cited Publications 12 Publications Verification LKB1/AAK1 dual inhibitor	Pim	Cancer
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with K_d values of 35 nM/53 nM/75 nM/380 nM for *Pim1/AKK1/MST2/LKB1* respectively, and also inhibits MPSK1 and TNIK.

HY-N0059

D-Arabinose	Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-113788

PF-719	Pyk2 p38 MAPK Amyloid-β	Neurological Disease Inflammation/Immunology
PF-719 is a highly selective Pyk2 inhibitor with an IC₅₀ value of 17 nM. PF-719 promotes the activation of *LKB1* and p38 MAPK. PF-719 blocks synaptic deficits induced by Amyloid-beta oligomers and reverses the inhibition of long-term potentiation induced by β-amyloid oligomers. PF-719 can be used in research related to Alzheimer's disease and autoimmune diseases ^[1] .

HY-N0385

Gomisin J 3 Publications Verification	NO Synthase AMPK CaMK NF-κB Keap1-Nrf2	Cardiovascular Disease Inflammation/Immunology
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, *Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK* pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc ^[1] .

HY-N7082

D-Arabinopyranose	Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-18555

TMPA 3 Publications Verification	Nuclear Hormone Receptor 4A/NR4A AMPK	Metabolic Disease Inflammation/Immunology Cancer
TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of *LKB1* in the cytoplasm to activate AMPKα. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation ^[1] .

HY-121006

Biguanide	Mitochondrial Metabolism AMPK Insulin Receptor	Metabolic Disease Cancer
Biguanide is an orally active antihyperglycemic agent. Biguanide inhibits mitochondrial ATP production, activates the *LKB1-AMPK* signaling pathway, and damages the energy homeostasis. Biguanide enhances insulin-receptor activation and downstream signaling. Biguanide exhibits potential in ameliorating the type 2 diabetes and the insulin-associated cancers.

HY-P5435

LKBtide	Ser/Thr Kinase	Others
LKBtide is a biological active peptide. (This is a peptide substrate that is phosphorylated by Serine/Threonine kinase 11 (STK11), also known as LKB1. LKBtide is derived from sucrose non-fermenting 1 (SNF1) protein kinase, which is normally activated by the LKB1/AMP-activated protein kinase (AMPK) signaling pathway.)

HY-RS13921

STK11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STK11 Human Pre-designed siRNA Set A contains three designed siRNAs for STK11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STK11 Human Pre-designed siRNA Set A STK11 Human Pre-designed siRNA Set A

HY-174803

WMJ-J-09	p38 MAPK HDAC AMPK MDM-2/p53 Microtubule/Tubulin Pim Survivin Apoptosis	Cancer
WMJ-J-09 is an HDAC inhibitor with IC₅₀ values of 7.5 nM (HDAC1), 21.3 nM (HDAC2), 18.4 nM (HDAC3), 90.9 nM (HDAC8), 3.9 nM (HDAC6) and 8715.7 nM (HDAC4). WMJ-J-09 blocks the cell cycle and induces apoptosis in cancer cells. WMJ-J-09 induces cancer cell death through the LKB1-AMPK-p38MAPK-p63-survivin signaling cascade.WMJ-J-09 inhibits HDAC enzyme activity, leading to acetylation of key proteins and thereby regulating cancer cell death. WMJ-J-09 can be used in HCT116 cells and FaDu cells research^[1][2].

HY-N0059R

D-Arabinose (Standard)	Reference Standards Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose (Standard) is the analytical standard of D-Arabinose. This product is intended for research and analytical applications. D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S1

D-Arabinose-13C-1	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose- ¹³C-1 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S3

D-Arabinose-13C-3	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose- ¹³C-3 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N6904

Crocetin monomethyl ester 1 Publications Verification	Amyloid-β	Neurological Disease Inflammation/Immunology
Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity ^[1] . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway .

HY-N6904R

Crocetin monomethyl ester (Standard)	Reference Standards Amyloid-β	Neurological Disease Inflammation/Immunology
Crocetin monomethyl ester (Standard) is the analytical standard of Crocetin monomethyl ester. This product is intended for research and analytical applications. Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity ^[1] . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway .

HY-E70851

Nuak2 Recombinant Human Active Protein Kinase	AMPK	Cancer
NUAK2 is a member of the SNF1/AMP kinase (AMPK) family (serine/threonine kinases) that is regulated by the putative tumor suppressor LKB1 (20-23) and also by death receptor signaling through NF-κB. Nuak2 Recombinant Human Active Protein Kinase is a recombinant Nuak2 protein that can be used to study Nuak2-related functions ^[1].

HY-N0059S4

D-Arabinose-d2	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose-d₂ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S

D-Arabinose-13C	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose- ¹³C is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S6

D-Arabinose-d6	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose-d₆ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S5

D-Arabinose-d5	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose-d₅ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S2

D-arabinose-13C-2	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose- ¹³C-2 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N7082S

D-Arabinopyranose-13C5	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinopyranos- ¹³C₅ is ¹³C labeled D-Arabinopyranos (HY-N7082). D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-10371R

Pim1/AKK1-IN-1 (Standard) LKB1/AAK1 dual inhibitor (Standard)	Reference Standards Pim	Cancer
Pim1/AKK1-IN-1 (Standard) is the analytical standard of Pim1/AKK1-IN-1 (HY-10371). This product is intended for research and analytical applications. Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with K_d values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.

HY-E70802

Biotin-Nuak2 Recombinant Human Active Protein Kinase	AMPK	Cancer
NUAK2 is a member of the SNF1/AMP kinase (AMPK) family (serine/threonine kinases) that is regulated by the putative tumor suppressor LKB1 (20-23) and also by death receptor signaling through NF-κB. Biotin-Nuak2 Recombinant Human Active Protein Kinase is a recombinant Nuak2 protein that can be used to study Nuak2-related functions, and is biotinylated ^[1].

HY-N3055

Pinusolide	Apoptosis AMPK Platelet-activating Factor Receptor (PAFR) Caspase	Neurological Disease Metabolic Disease Cancer
Pinusolide is an AMPK activator and PAF receptor antagonist. Pinusolide activates AMPK, phosphorylates ACC, enhances *IRS-1* tyrosine phosphorylation, boosts glucose uptake, and modulates insulin signaling. Pinusolide inhibits caspase-3/7 activation, intracellular calcium elevation, reactive oxygen species overproduction, lipid peroxidation, and tumor cell proliferation. Pinusolide stabilizes superoxide dismutase activity, reduces apoptotic hallmarks, induces mitochondrial pathway apoptosis, and triggers DNA fragmentation. Pinusolide can be used for the research of type 2 diabetes, neurodegenerative diseases, acute lymphoblastic leukemia, acute myeloid leukemia, and Burkitt lymphoma ^[1] .

HY-RS23763

Stk11 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stk11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stk11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stk11 Rat Pre-designed siRNA Set A Stk11 Rat Pre-designed siRNA Set A

HY-RS17308

Stk11 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stk11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stk11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stk11 Mouse Pre-designed siRNA Set A Stk11 Mouse Pre-designed siRNA Set A

HY-W800535

Cryptolepine	NF-κB p38 MAPK mTOR Topoisomerase AMPK Apoptosis Cholinesterase (ChE) HIF/HIF Prolyl-Hydroxylase β-catenin	Infection Metabolic Disease Inflammation/Immunology Cancer
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of *c-Myc, mTOR, NF-κB, HIF-1, MAPK* and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P5435

LKBtide	Ser/Thr Kinase	Others
LKBtide is a biological active peptide. (This is a peptide substrate that is phosphorylated by Serine/Threonine kinase 11 (STK11), also known as LKB1. LKBtide is derived from sucrose non-fermenting 1 (SNF1) protein kinase, which is normally activated by the LKB1/AMP-activated protein kinase (AMPK) signaling pathway.)

D-Arabinose	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Parasite Bacterial AMPK PPAR
D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

Gomisin J 3 Publications Verification	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Source Classification	NO Synthase AMPK CaMK NF-κB Keap1-Nrf2
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, *Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK* pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc ^[1] .

D-Arabinopyranose	Infection Microorganisms Classification of Application Fields Disease Research Fields Saccharides Monosaccharides Source Classification	Parasite Bacterial AMPK PPAR
D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

D-Arabinose (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Saccharides Source Classification	Reference Standards Parasite Bacterial AMPK PPAR
D-Arabinose (Standard) is the analytical standard of D-Arabinose. This product is intended for research and analytical applications. D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

Crocetin monomethyl ester 1 Publications Verification	Neurological Disease Classification of Application Fields Terpenoids Diterpenoids Lridaceae Plants Crocus sativus L. Inflammation/Immunology Disease Research Fields Source Classification	Amyloid-β
Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity ^[1] . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway .

Crocetin monomethyl ester (Standard)	Structural Classification Terpenoids Diterpenoids Lridaceae Plants Crocus sativus L. Source Classification	Reference Standards Amyloid-β
Crocetin monomethyl ester (Standard) is the analytical standard of Crocetin monomethyl ester. This product is intended for research and analytical applications. Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity ^[1] . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway .

Pinusolide	Cupressaceae Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Calocedrus decurrens (Torr.) Florin Source Classification Cancer	Apoptosis AMPK Platelet-activating Factor Receptor (PAFR) Caspase
Pinusolide is an AMPK activator and PAF receptor antagonist. Pinusolide activates AMPK, phosphorylates ACC, enhances *IRS-1* tyrosine phosphorylation, boosts glucose uptake, and modulates insulin signaling. Pinusolide inhibits caspase-3/7 activation, intracellular calcium elevation, reactive oxygen species overproduction, lipid peroxidation, and tumor cell proliferation. Pinusolide stabilizes superoxide dismutase activity, reduces apoptotic hallmarks, induces mitochondrial pathway apoptosis, and triggers DNA fragmentation. Pinusolide can be used for the research of type 2 diabetes, neurodegenerative diseases, acute lymphoblastic leukemia, acute myeloid leukemia, and Burkitt lymphoma ^[1] .

Cryptolepine	Malvaceae Structural Classification Alkaloids Sida acuta Burm. F. Quinoline Alkaloids Plants Indole Alkaloids Source Classification	NF-κB p38 MAPK mTOR Topoisomerase AMPK Apoptosis Cholinesterase (ChE) HIF/HIF Prolyl-Hydroxylase β-catenin
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of *c-Myc, mTOR, NF-κB, HIF-1, MAPK* and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection ^[1] .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71549

	STK11 Protein, Human (His-SUMO) hLKB1; Liver kinase B1; LKB1; PJS; Polarization related protein LKB1; Renal carcinoma antigen NY-REN-19; Serine/Threonine Kinase 11; Serine/threonine protein kinase 11; Serine/threonine protein kinase LKB1; Serine/threonine protein kinase STK11; Serine/threonine-protein kinase 11; Serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase XEEK1; Stk11; STK11_HUMAN	Human	E. coli
	The STK11 protein is a tumor suppressor kinase that complexly regulates members of the AMP-activated protein kinase (AMPK) family, affecting cellular processes such as metabolism, apoptosis, and DNA damage responses. It phosphorylates the T-loop of AMPK family proteins and activates PRKAA1, PRKAA2 and other proteins (except MELK). STK11 Protein, Human (His-SUMO) is the recombinant human-derived STK11 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

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HY-N0059S1

D-Arabinose-13C-1
D-Arabinose- ¹³C-1 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

D-Arabinose-13C-1

D-Arabinose- ¹³C-1 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S3

D-Arabinose-13C-3
D-Arabinose- ¹³C-3 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

D-Arabinose-13C-3

D-Arabinose- ¹³C-3 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S4

D-Arabinose-d2
D-Arabinose-d₂ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing *CRTC1* transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

D-Arabinose-d2

D-Arabinose-d₂ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S

D-Arabinose-13C

D-Arabinose- ¹³C is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S6

D-Arabinose-d6

D-Arabinose-d₆ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S5

D-Arabinose-d5

D-Arabinose-d₅ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N0059S2

D-arabinose-13C-2

D-Arabinose- ¹³C-2 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

HY-N7082S

D-Arabinopyranose-13C5

D-Arabinopyranos- ¹³C₅ is ¹³C labeled D-Arabinopyranos (HY-N7082). D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) ^[1] .

Host:	Mouse (3) Rabbit (1)
Reactivity:	Human (4) Rat (2) Mouse (4) Monkey (2)
Application:	IHC-P (1) ICC/IF (1) IP (1) WB (4) FC (2) ELISA (3)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86340

	LKB1 Antibody (YA6032) STK11; LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	LKB1 Antibody (YA6032) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LKB1.

HY-P85260

	LKB1 Antibody (YA4952) STK11; LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19	WB, IHC-P	Human, Mouse, Rat
	LKB1 Antibody (YA4952) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to LKB1.

HY-P84605

	STK11 Antibody (YA4302) PJS; LKB1; STK11	WB, FC, ELISA	Human, Mouse, Monkey
	STK11 Antibody (YA4302) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to STK11.

HY-P84605A

	STK11 Antibody (YA4302)(PBS only) PJS; LKB1; STK11	WB, FC, ELISA	Human, Mouse, Monkey
	STK11 Antibody (YA4302) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to STK11.