2 Results for "

LecA

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "LecA" in MCE Product Catalog:

D(+)-Raffinose pentahydrate
D(+)-Raffinose pentahydrate
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Cat. No.: HY-N1938
CAS No.: 17629-30-0
Synonyms: D-Raffinose pentahydrate
Category:  

other families Polysaccharides Other Diseases Plants Endogenous metabolite Disease Research Fields Saccharides

Target:  

Endogenous Metabolite Glucosylceramide Synthase (GCS) Bacterial Phosphodiesterase (PDE) Interleukin Related

D(+)-Raffinose pentahydrate is an orally active inhibitor of LecA (Kd = 32 μM) and GtfC. D(+)-Raffinose pentahydrate reduces cyclic diguanylate (c-di-GMP) by increased activity of a c-di-GMP specific phosphodiesterase. D(+)-Raffinose pentahydrate interferes with GTF function. D(+)-Raffinose pentahydrate decreases IL-4 and IL-5 mRNA. D(+)-Raffinose pentahydrate exhibits biofilm-inhibitory activity against Pseudomonas aeruginosa and Streptococcus mutans and inhibits allergic airway eosinophilia .
Antibacterial agent 130
Antibacterial agent 130
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Cat. No.: HY-152175
CAS No.: 1502721-60-9
Target:  

Bacterial

Domaines de recherche:  

Infection

Antibacterial agent 130 is a 1,1-diarylthiogalactoside, used for targeting the Pseudomonas aeruginosa LecA. Antibacterial agent 130 shows high affinity toward LecA (Kd=1 μM). Antibacterial agent 130 has antibiofilm activity, but lacks bactericidal activity. LecA, a lectin and virulence factor from Pseudomonas aeruginosa involved in bacterial adhesion and biofilm formation .
Assay Types