Antibacterial agent 130 

Antibacterial agent 130 is a 1,1-diarylthiogalactoside, used for targeting the Pseudomonas aeruginosa LecA. Antibacterial agent 130 shows high affinity toward LecA (K_d=1 μM). Antibacterial agent 130 has antibiofilm activity, but lacks bactericidal activity. LecA, a lectin and virulence factor from Pseudomonas aeruginosa involved in bacterial adhesion and biofilm formation^[1].

Antibacterial agent 130 (compound 8a) (0.08-5 mM; 2-24 h) dose-dependently inhibits bacterial biofilm formation with 100% of inhibition at 5 mM^[1].
Antibacterial agent 130 (0.01-5 mM; 24 h) has cytotoxicity against MRC-5 cell line (human fetal lung fibroblast cells) at concentration higher than 1.25 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

496.53

C₂₃H₂₈O₁₀S

1502721-60-9

OC[C@H]1O[C@@H](SC2=C(OC)C=CC(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)=C2)[C@H](O)[C@@H](O)[C@H]1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bruneau A, et al. Discovery of potent 1,1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties. Eur J Med Chem. 2022 Dec 15;247:115025.  [Content Brief]