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Results for "

MAGL-IN-1

" in MedChemExpress (MCE) Product Catalog:

6

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1

天然物

製品番号 製品名 Target 研究分野 構造式
  • HY-111538
    MAGL-IN-1
    1 Publications Verification

    		 MAGL Cancer
    MAGL-IN-1 is a potent, selective, reversible and competitive inhibitor of MAGL, with an IC50 of 80 nM. MAGL-IN-1 exhibits anti-proliferative effects against human breast, colorectal, and ovarian cancer cells. MAGL-IN-1 blocks MAGL in cell-based as well as in vivo assays [1].
    MAGL-IN-1
  • HY-N2512
    1-Monomyristin
    1 Publications Verification

    		 Environmental Pollutants Endogenous Metabolite FAAH Autophagy Bacterial Fungal Infection Cancer
    1-Monomyristin acts as an insecticide, enzyme inhibitor, antibacterial and antifungal agent, with an IC50 of 18 μM against rat FAAH and an IC50 of 32 μM against rat MAGL. 1-Monomyristin inhibits 2-oleoylglycerol hydrolysis via MAGL. 1-Monomyristin suppresses the growth of Staphylococcus aureus, Aggregatibacter actinomycetemcomitans and Candida albicans. 1-Monomyristin is lethal to brine shrimp . 1-Monomyristin exhibits marginal cytotoxicity against prostate cancer cells. 1-Monomyristin is applicable to research related to bacterial infections, fungal infections, renal cancer, prostate adenocarcinoma and pancreatic cancer [1] .
    1-Monomyristin
  • HY-143263
    FAAH/MAGL-IN-1

    		FAAH MAGL Neurological Disease
    FAAH/MAGL-IN-1 (compound SIH 3) is a potent FAAH and MAGL inhibitor with IC50s of 31 nM and 29 nM, respectively. FAAH/MAGL-IN-1 has the potential for the research of neuropathic pain [1].
    FAAH/MAGL-IN-1
  • HY-173369
    PROTAC MAGL degrader-1

    		PROTACs MAGL Cancer
    PROTAC MAGL degrader-1 is an orally active PROTAC agent that simultaneously targets monoacylglycerol lipase (MAGL) and E3 ubiquitin ligase MDM2. PROTAC MAGL degrader-1 degrades MAGL and inhibits the binding of MDM2 to p53. PROTAC MAGL degrader-1 can partially penetrate the blood-brain barrier (BBB). PROTAC MAGL degrader-1 induces glioblastoma stem cells (GSCs) apoptosis. (E3 ligase ligand: HY-128837; target protein ligand + linker: HY-173370; target protein inhibitor: HY-15249) [1].
    PROTAC MAGL degrader-1
  • HY-168145
    MAGL-IN-19

    		MAGL Cancer
    MAGL-IN-19 (compund 7o) is a highly potent and selective MAGL inhibitor .
    MAGL-IN-19
  • HY-173370
    MAGL Ligand-Linker Conjugate 1

    		E3 Ligase Ligand-Linker Conjugates Others
    MAGL Ligand-Linker Conjugate 1 is a conjugate of the MAGL ligand and the linker. MAGL Ligand-Linker Conjugate 1 can be used for synthesis of PROTAC degrader PROTAC MAGL degrader-1 (HY-173369) [1].
    MAGL Ligand-Linker Conjugate 1

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