Search Result

Results for "

METTL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	METTL3 (30) RNA MTase (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (12) Autophagy (2) Bcl-2 Family (2) c-Myc (1) Caspase (1) Cytochrome P450 (1) DNA Methyltransferase (5) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (5) Enterovirus (2) Epigenetic Reader Domain (1) Ferroptosis (2) Glutathione Peroxidase (2) Heme Oxygenase (HO) (2) Histone Methyltransferase (1) HIV (1) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (1) Keap1-Nrf2 (2) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (1) NF-κB (1) PROTAC Linkers (1) PROTACs (5) Pyruvate Kinase (2) Reactive Oxygen Species (ROS) (2) Reference Standards (3) Small Interfering RNA (siRNA) (35) TGF-β Receptor (2)
By Research Areas:	Cancer (34) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (5) Metabolic Disease (4) Neurological Disease (1)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (1) Rat Pre-designed siRNA Sets (8) Mouse Pre-designed siRNA Sets (8) Human Pre-designed siRNA Sets (19) siRNAs (35)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: METTL3 RNA MTase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134836

STM2457 Maximum Cited Publications 104 Publications Verification	Apoptosis METTL3	Cancer
STM2457 is a first-in-class, highly potent, selective and orally active *METTL3* inhibitor with an IC₅₀ of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML) .

HY-19528

SAH 15+ Cited Publications SAH (S-Adenosylhomocysteine)	Endogenous Metabolite	Metabolic Disease
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

HY-156677

STC-15 4 Publications Verification	METTL3	Cancer
STC-15 is an orally active RNA methyltransferase *METTL3* inhibitor with the activity of activating anti-tumor immunity and reshaping the tumor microenvironment. STC-15 inhibits tumor growth by activating anti-cancer immune responses associated with increased interferon signaling and synergizes with T-cell checkpoint blockade. STC-15 can be used in the study of proliferative diseases such as cancer and autoimmune diseases .

HY-W037893

CHMA1004 dihydrochloride 2 Publications Verification Methyl piperazine-2-carboxylate dihydrochloride; METTL3 activator-1	METTL3	Inflammation/Immunology
METTL3 activator-1 (2-Piperazinecarboxylic acid methyl ester dihydrochloride) is a *Mettl3* activator that can promote the expression of Mettl3. METTL3 activator-1 can be used for the study of liver fibrosis .

HY-156773

STM3006 2 Publications Verification	Apoptosis METTL3	Cancer
STM3006 is a highly potent, selective, and orally active inhibitor of *METTL3* (IC₅₀: 5 nM). STM3006 can reduce the m6A level, promote the formation of dsRNA, trigger a cell-intrinsic interferon response, and enhance the killing effect of T cells on tumors. STM3006 has anti-tumor activity, and its combination with anti-PD-1 immunotherapy yields better results .

HY-161402

METTL16-IN-1	DNA Methyltransferase	Cancer
METTL16-IN-1 is a potent *METTL16* inhibitor with an IC₅₀ value of 1.7 μM and a K_d value of 1.35 μM. Mettl16-in-1 inhibits the binding interaction of U6 snRNA deletion and METTL16 MTD with an IC₅₀ value of 2.5 μM. METTL16-IN-1 has antitumor activity .

HY-N0353

Curdione 2 Publications Verification (+)-Curdione	Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)	Cardiovascular Disease Neurological Disease Cancer
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

HY-160415

WD6305 2 Publications Verification	PROTACs Apoptosis METTL3	Cancer
WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC₅₀ values of 140 nM and 194 nM for *METTL3* and *METTL14, respectively. WD6305 inhibits m ⁶A* modification and proliferation of AML cells, and induces apoptosis. WD6305 has antitumor activity .(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))

HY-115717

UZH2 1 Publications Verification	METTL3	Cancer
UZH2 is a potent and selective *METTL3* inhibitor with an IC₅₀ value of 5 nM.

HY-178159

SA91-0178	RNA MTase	Inflammation/Immunology
SA91-0178 is a *METTL1* inhibitor. SA91-0178 inhibits m ⁷G methylation of RNA, reduces SARM1 stability, mitigates NAD ⁺ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases .

HY-162080

METTL1-WDR4-IN-1 1 Publications Verification	DNA Methyltransferase Pyruvate Kinase	Cancer
METTL1-WDR4-IN-1 (Compound 1) is a selective competitive inhibitor of the methyltransferase complex *METTL1-WDR4* (IC₅₀ = 144 μM). METTL1-WDR4-IN-1 inhibits the m ⁷G methyltransferase activity of the METTL1-WDR4 complex, blocking m ⁷G modification of PKM mRNA, reducing PKM2 protein expression, disrupting the *METTL1/PKM2/H3K9la* positive feedback loop, and simultaneously inhibiting PKM2 nuclear translocation-mediated CD155 transcriptional activation. METTL1-WDR4-IN-1 can inhibit tumor cell proliferation, weaken glycolytic metabolism, reverse tumor immune evasion (restoring NK cell and CD8 ⁺ T cell function), and regulate RNA epigenetic modification and the tumor immune microenvironment. METTL1-WDR4-IN-1 can be used in immunotherapy research for cancers such as colorectal cancer, and is particularly suitable for use in combination with PKM2 inhibitors to enhance anti-tumor treatment efficacy .

HY-160415A

WD6305 TFA 2 Publications Verification	PROTACs Apoptosis METTL3	Cancer
WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 TFA has DC₅₀ values of 140 nM and 194 nM for *METTL3* and *METTL14, respectively. WD6305 TFA inhibits m ⁶A* modification and proliferation of AML cells, and induces apoptosis. WD6305 TFA has antitumor activity .(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))

HY-153625

STM2120 2 Publications Verification	METTL3	Cancer
STM2120 is a *METTL3-METTL14* inhibitor with an IC₅₀ of 64.5 μM .

HY-19528S

SAH-d4 SAH (S-Adenosylhomocysteine)-d₄	Endogenous Metabolite	Metabolic Disease
SAH-d₄ is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 μM .

HY-P10387

RSM3 1 Publications Verification	METTL3 Apoptosis MDM-2/p53 NF-κB Caspase	Cancer
RSM3 is a *METTL3-METTL14* complex inhibitor with a K_d of 3.10 μM for the *METTL3-METTL14* complex. RSM3 reduces the m ⁶A modification level of SLC31A1 and the global RNA methylation level. RSM3 upregulates programmed cell death-related genes, enhances cell apoptosis, inhibits pro-cancer signals and suppresses tumor growth. RSM3 is applicable to the research of preeclampsia and cancer .

HY-134673A

UZH1a 3 Publications Verification	Apoptosis	Cancer
UZH1a is a potent and selective *METTL3* inhibitor, with an IC₅₀ of 280 nM. UZH1a can be used for epitranscriptomic modulation of cellular processes. UZH1a has antitumor activity. UZH1a also can be used as a chemical probe for studying METTL3 .

HY-174873

AF151	PROTACs METTL3 Apoptosis Bcl-2 Family	Cancer
AF151 is a METTL3 PROTAC degrader with the DC₅₀ of 0.43 μM in MOLM-13 cells. AF151 inhibits cell growth by significantly degrading *METTL3* protein and reducing m6A levels. AF151 can induce cell apoptosis and reduce the level of Bcl-2 protein. AF151 can be used for research on cancer such as acute myeloid leukemia (AML). (Pink: METTL3 Ligand (HY-174874); Blue: VHL Ligand (HY-125845); Black: Linker; VHL Ligand+Linker (HY-174875)) .

HY-134673

UZH1 3 Publications Verification	Apoptosis	Cancer
UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective *METTL3* inhibitor, with an IC₅₀ of 280 nM. UZH1b (IC₅₀=28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3 .

HY-168878

EP652	METTL3	Cancer
EP652 is a *METTL3* inhibitor and antitumor agent with IC₅₀ values of 2 nM, <10 nM, and 37 nM in SPA, intracellular, and ATPlite assays, respectively. EP652 exhibits high selectivity against 40 other methyltransferases and FTO, and possesses favorable pharmacokinetic parameters. EP652 reduces intracellular N ⁶-methyladenosine (m ⁶A) levels in mRNA. EP652 inhibits tumor growth and progression of both hematologic malignancies and solid tumors. EP652 can be used for the research of acute myeloid leukemia, ovarian cancer, non-small cell lung cancer, and hypopharyngeal squamous cell carcinoma .

HY-N0086R

N6-Methyladenosine (Standard) 1 Publications Verification 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Endogenous Metabolite Influenza Virus Reference Standards	Infection
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

HY-N4031

Humantenine	Anaplastic lymphoma kinase (ALK) METTL3	Inflammation/Immunology
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD₅₀ values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-158404

METTL3-IN-8	METTL3	Inflammation/Immunology
METTL3-IN-8 (F039-0002) is a potent *METTL3* inhibitor. METTL3-IN-8 strongly ameliorates Dextran sulfate sodium salt (DSS) (HY-116282C)-induced colitis. METTL3-IN-8 can be used Inflammatory bowel disease (IBD) research .

HY-159604

METTL3-IN-9	METTL3	Cancer
METTL3-IN-9 (compound C3) is an inhibitor of methyltransferase-like *METTL3*, an RNA methyltransferase that catalyzes the N6-methyladenosine (m6A) modification of mRNA in eukaryotic cells .

HY-19528R

SAH (Standard) SAH (S-Adenosylhomocysteine) (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
SAH (Standard) is the analytical standard of SAH. This product is intended for research and analytical applications. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .

HY-148468

METTL3-IN-2	METTL3	Cancer
METTL3-IN-2 (compound 28) is a *METTL3* inhibitor with an IC₅₀ value of 6.1 nM. METTL3-IN-2 inhibits cell proliferation of Caov3 cancer cells .

HY-162082

METTL1-WDR4-IN-2	DNA Methyltransferase	Cancer
METTL1-WDR4-IN-2, an adenosine derivative, is a selective methyltransferase Like 1 (METTL1)-WDR4 inhibitor with an IC₅₀ of 41 μM. METTL1-WDR4-IN-2 shows selectivity against METTL3-14 (IC₅₀ of 958 μM) and METTL16 (IC₅₀ of 208 μM). METTL1-WDR4-IN-2 can be used for the study of cancer .

HY-162930

*PROTAC METTL3 degrader 1*	PROTACs METTL3	Cancer
PROTAC METTL3 degrader 1 is a VHL-based PROTAC METTL3 degrader (DC₅₀: 220 nM in MOLM-13 cells). PROTAC METTL3 degrader 1 inhibits METTL3/14 complex with an IC₅₀ value of 341 nM. PROTAC METTL3 degrader 1 can be used for the research of acute myeloid leukemia and gastric cancer .

HY-RS08364

METTL3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
METTL3 Human Pre-designed siRNA Set A contains three designed siRNAs for METTL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

METTL3 Human Pre-designed siRNA Set A METTL3 Human Pre-designed siRNA Set A

HY-RS08355

METTL14 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
METTL14 Human Pre-designed siRNA Set A contains three designed siRNAs for METTL14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

METTL14 Human Pre-designed siRNA Set A METTL14 Human Pre-designed siRNA Set A

HY-RS23843

Mettl16 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mettl16 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mettl16 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mettl16 Rat Pre-designed siRNA Set A Mettl16 Rat Pre-designed siRNA Set A

HY-P10387A

RSM3 TFA 1 Publications Verification	METTL3 Apoptosis	Cancer
RSM3 TFA, a stapled peptide, is a *METTL3-METTL14* inhibitor with an K_d of 3.10 μM. RSM3 TFA inhibits tumor growth while induces cell apoptosis. RSM3 TFA can be used for study of cancer .

HY-178446

METTL3-IN-11	METTL3 c-Myc Bcl-2 Family	Cancer
METTL3-IN-11 is an excellent, selective *METTL3* inhibitor (IC₅₀ = 45.31 nM). METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1, EZH1, MLL1, and PRMT1. METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis, and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes (c-MYC and BCL2). METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia .

HY-148469

METTL3-IN-3	METTL3	Others
METTL3-IN-3 (compound 11) is a polyheterocyclic compound, acts as *METTL3* inhibitor .

HY-162282

*PROTAC METTL3-14 degrader 1*	PROTACs DNA Methyltransferase	Cancer
PROTAC METTL3-14 degrader 1 (compound 30) is a PROTAC degrader of *METTL3-14. PROTAC METTL3-14 degrader 1 shows a 50% or higher degradation of METTL3* and/or *METTL14*(Pink: Ligand for target protein (HY-115717); Black: Linker (HY-168686); Blue: Ligand for E3 ligase (HY-10984)) .

HY-RS16861

Mettl14 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mettl14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mettl14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mettl14 Mouse Pre-designed siRNA Set A Mettl14 Mouse Pre-designed siRNA Set A

HY-RS16508

Mettl3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mettl3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mettl3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mettl3 Mouse Pre-designed siRNA Set A Mettl3 Mouse Pre-designed siRNA Set A

HY-RS08359

METTL18 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
METTL18 Human Pre-designed siRNA Set A contains three designed siRNAs for METTL18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

METTL18 Human Pre-designed siRNA Set A METTL18 Human Pre-designed siRNA Set A

HY-151924

Antiviral agent 23	Enterovirus	Infection
Antiviral agent 23 (compound 11b) is an antiviral agent to enterovirus 71 (EV71) with an EC₅₀ value of 94 nM. Antiviral agent 23 effectively suppresses the activity of METTL3/METTL14. Antiviral agent 23 can be used for the research of infection .

HY-156759

METTL3-IN-5	METTL3	Cancer
METTL3-IN-5 (Compound 13) is a *METTL3* inhibitor. METTL3-IN-5 inhibits MOLM-13 growth with an IC₅₀ less than 2 μM. METTL3-IN-5 has weak hERG inhibitory activity (IC₅₀ >30 μM). METTL3-IN-5 can be used for AML research .

HY-179239

METTL3-IN-12	METTL3	Cancer
METTL3-IN-12 (Compound 15) is a selective *METTL3* inhibitor with an IC₅₀ of 50 nM. METTL3-IN-12 exhibits significant anti-proliferative activity in various leukemia cell lines. METTL3-IN-12 can be used for research on leukemia .

HY-158403

METTL3-IN-7	METTL3	Inflammation/Immunology
METTL3-IN-7 (7460-0250) is a potent *METTL3* inhibitor. METTL3-IN-7 strongly ameliorates Dextran sulfate sodium salt (DSS) (HY-116282C)-induced colitis. METTL3-IN-7 can be used Inflammatory bowel disease (IBD) research .

HY-148467

METTL3-IN-1	METTL3	Others
METTL3-IN-1 (compound 23) is a polyheterocyclic compound, acts as *METTL3* inhibitor .

HY-W125425

CHMA1004 Methyl piperazine-2-carboxylate; METTL3 activator-1 free base	HIV METTL3	Infection
METTL3 activator-1 free base (compound 4) is a potent *METTL3/METTL14/WTAP* activator. METTL3 activator-1 free base increases HIV-1 p24 virion production. METTL3 activator-1 free base increases the N6-adenosine methylation level in the viral RNA genome .

HY-178947

ZINC13000658	METTL3 Apoptosis	Cancer
ZINC13000658 is a *METTL* inhibitor. ZINC13000658 exhibits significant anti proliferative activity in various cells and can induce G1 phase cell cycle arrest and apoptosis such as HepG2 (IC₅₀ = 5.632 µM) and SNU-449 (IC₅₀ = 6.184 µM) cells. ZINC13000658 may be related to the inhibition of the activity of multiple methyltransferases such as METTL1, 3, 6, 16, 18, etc. ZINC13000658 can be used for research on various types of cancer .

HY-19528S2

SAH-13C10	Endogenous Metabolite	Metabolic Disease
SAH- ¹³C₁₀ is the ¹³C labeled SAH . SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 μM .

HY-151926

Antiviral agent 24	Enterovirus	Infection
Antiviral agent 24 is a potent antiviral agent with EC₅₀ values of 0.101, 19.9, 91.2 µM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner .

HY-134673B

UZH1b	METTL3	Others
UZH1b is an enantiomer of UZH1a (a METTL3 inhibitor). UZH1b is essentially inactive for METTL3 (IC₅₀=28 µM) .

HY-174874

POI-4	METTL3 Ligands for Target Protein for PROTAC	Cancer
POI-4 is a ligand for *METTL3*. POI-4 can be used for synthesizing PROTACs such as AF151 (HY-174873) .

HY-154997

7OQL	METTL3	Cancer
7OQL (compound 54) is a selective *METTL3* inhibitor (IC₅₀=0.054 µM). 7OQL has the potential to be used in the study of cancer .

HY-162080A

METTL1-WDR4-IN-1 TFA 1 Publications Verification	DNA Methyltransferase Pyruvate Kinase	Cancer
METTL1-WDR4-IN-1 (Compound 1) TFA is a selective competitive inhibitor of the methyltransferase complex *METTL1-WDR4* (IC₅₀=144 μM). METTL1-WDR4-IN-1 TFA inhibits the m ⁷G methyltransferase activity of the METTL1-WDR4 complex, blocking the m ⁷G modification of PKM mRNA, reducing PKM2 protein expression, disrupting the *METTL1/PKM2/H3K9la* positive feedback loop, and simultaneously inhibiting PKM2 nuclear translocation-mediated CD155 transcriptional activation. METTL1-WDR4-IN-1 TFA can inhibit tumor cell proliferation, weaken glycolytic metabolism, reverse tumor immune evasion (restoring NK cell and CD8 ⁺ T cell function), and regulate RNA epigenetic modification and the tumor immune microenvironment. METTL1-WDR4-IN-1 TFA can be used in immunotherapy research for cancers such as colorectal cancer, and is particularly suitable for use in combination with PKM2 inhibitors to enhance anti-tumor treatment efficacy .

Cat. No.	Product Name	Target	Research Area

HY-P10387

RSM3 1 Publications Verification	METTL3 Apoptosis MDM-2/p53 NF-κB Caspase	Cancer
RSM3 is a *METTL3-METTL14* complex inhibitor with a K_d of 3.10 μM for the *METTL3-METTL14* complex. RSM3 reduces the m ⁶A modification level of SLC31A1 and the global RNA methylation level. RSM3 upregulates programmed cell death-related genes, enhances cell apoptosis, inhibits pro-cancer signals and suppresses tumor growth. RSM3 is applicable to the research of preeclampsia and cancer .

HY-P10387A

RSM3 TFA 1 Publications Verification	METTL3 Apoptosis	Cancer
RSM3 TFA, a stapled peptide, is a *METTL3-METTL14* inhibitor with an K_d of 3.10 μM. RSM3 TFA inhibits tumor growth while induces cell apoptosis. RSM3 TFA can be used for study of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-19528

SAH 15+ Cited Publications SAH (S-Adenosylhomocysteine)	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Disease markers Metabolic Disease Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

HY-N0353

Curdione 2 Publications Verification (+)-Curdione	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Other Diseases Curcuma phaeocaulis Valeton Plants Disease Research Fields Source Classification Zingiberaceae	Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

HY-N0086R

N6-Methyladenosine (Standard) 1 Publications Verification 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite Influenza Virus Reference Standards
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

HY-N4031

Humantenine	Alkaloids Structural Classification Classification of Application Fields Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Source Classification	Anaplastic lymphoma kinase (ALK) METTL3
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD₅₀ values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-19528R

SAH (Standard) SAH (S-Adenosylhomocysteine) (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Disease markers Amino acids Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
SAH (Standard) is the analytical standard of SAH. This product is intended for research and analytical applications. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .

HY-N0353R

Curdione (Standard) (+)-Curdione (Standard)	Structural Classification Terpenoids Sesquiterpenes Curcuma phaeocaulis Valeton Plants Source Classification Zingiberaceae	Reference Standards Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione (Standard) is the analytical standard of Curdione. This product is intended for research and analytical applications. Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

Species:	Human (11)
Tag:	His (6) Tag Free (1) Strep (1) GST (3) Flag (1)
Source:	Sf9 insect cells (4) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703633

	METTL14-METTL3 Protein, Human (sf9, His, Strep) KIAA1627	Human	Sf9 insect cells

HY-P703050

	METTL2A Protein, Human (sf9, GST) METTL2; HSPC266	Human	Sf9 insect cells
	METTL2A Protein, Human (sf9, GST) is the recombinant human-derived METTL2A, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P705431

	METTL7B Protein, Human (His) METTL7B; TMT1B; Methyltransferase-like protein 7B; Thiol S-methyltransferase METTL7B	Human	E. coli

HY-P75926

	METTL1 Protein, Human (His) tRNA (guanine-N(7)-)-methyltransferase; Methyltransferase-like protein 1; METTL1; C12orf1	Human	E. coli
	The METTL1 protein is a catalytic component of the METTL1-WDR4 methyltransferase complex, which promotes the formation of N(7)-methylguanine in tRNA, mRNA, and miRNA. METTL1 Protein, Human (His) is the recombinant human-derived METTL1 protein, expressed by E. coli , with N-His labeled tag.

HY-P702912

	METTL3 Protein, Human (sf9, FLAG) MTA70	Human	Sf9 insect cells
	METTL3 Protein, Human (sf9, FLAG) is the recombinant human-derived METTL3, expressed by Sf9 insect cells , with N-Flag labeled tag. ,

HY-P703029

	METTL3 Protein, Human (sf9, GST) MTA70	Human	Sf9 insect cells
	METTL3 Protein, Human (sf9, GST) is the recombinant human-derived METTL3, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P705610

	METTL14 Protein, Human (His) Methyltransferase-like protein 14; hMETTL14	Human	E. coli

HY-P77447

	METTL11A Protein, Human N-terminal Xaa-Pro-Lys N-methyltransferase 1; NTM1A; NTMT1; C9orf32; METTL11A; NRMT; NRMT1	Human	E. coli
	The METTL11A protein methylates the N-terminus of target proteins, specifically catalyzing monomethylation, dimethylation, or trimethylation of exposed α-amino groups in the [Ala/Gly/Ser]-Pro-Lys motif. METTL11A Protein, Human is the recombinant human-derived METTL11A protein, expressed by E. coli.

HY-P77448

	METTL11A Protein, Human (GST) N-terminal Xaa-Pro-Lys N-methyltransferase 1; NTM1A; NTMT1; C9orf32; METTL11A; NRMT; NRMT1	Human	E. coli
	The METTL11A protein methylates the N-terminus of target proteins, specifically catalyzing monomethylation, dimethylation, or trimethylation of exposed α-amino groups in the [Ala/Gly/Ser]-Pro-Lys motif. METTL11A Protein, Human (GST) is the recombinant human-derived METTL11A protein, expressed by E. coli , with N-GST labeled tag.

HY-P700638

	METTL11A Protein, Human (His) N-terminal Xaa-Pro-Lys N-methyltransferase 1; NTM1A; NTMT1; C9orf32; METTL11A; NRMT; NRMT1	Human	E. coli
	The METTL11A protein methylates the N-terminus of target proteins, specifically catalyzing monomethylation, dimethylation, or trimethylation of exposed α-amino groups in the [Ala/Gly/Ser]-Pro-Lys motif.METTL11A Protein, Human (His) is the recombinant human-derived METTL11A protein, expressed by E.coli , with N-6*His labeled tag.

HY-P705470

	METTL3 Protein, Human (His) Methyltransferase-like protein 3; hMETTL3; N6-adenosine-methyltransferase 70 kDa subunit; MT-A70	Human	E. coli

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Cat. No.	Product Name	Chemical Structure

HY-19528S

SAH-d4
SAH-d₄ is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 μM .

HY-19528S2

SAH-13C10
SAH- ¹³C₁₀ is the ¹³C labeled SAH . SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 μM .

Host:	Mouse (4) Rabbit (3)
Reactivity:	Human (7) Rat (5) Mouse (3) Monkey (1)
Application:	IHC-P (7) ICC/IF (2) IP (2) WB (3) FC (2) ELISA (1)
Isotype:	IgG (3) IgG1 (2) IgG2a (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (5) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80223

	METTL3 Antibody (YA294) 1 Publications Verification	WB, IHC-P, FC	Human, Mouse, Rat
	METTL3 Antibody (YA294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to METTL3.

HY-P88324

	METTL7A Antibody (YA8008) AAM-B	IHC-P	Human, Rat
	METTL7A Antibody (YA8008) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to METTL7A.

HY-P88324A

	METTL7A Antibody (YA8008)(PBS only) AAM-B	IHC-P	Human, Rat
	METTL7A Antibody (YA8008) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to METTL7A.

HY-P86961

	METTL14 Antibody (YA6654) KIAA1627 antibody; MET14_HUMAN antibody; Methyltransferase like 14 antibody; Methyltransferase-like protein 14 antibody; METTL14 antibody; N6-adenosine-methyltransferase subunit METTL14 antibody; OTTHUMP00000219837 antibody;	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat, Monkey
	METTL14 Antibody (YA6654) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to METTL14.

HY-P88995

	*C12orf26 (METTL25) Antibody (YA8679)* C12orf26	IHC-P	Human
	C12orf26 (METTL25) Antibody (YA8679) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C12orf26 (METTL25).

HY-P88995A

	*C12orf26 (METTL25) Antibody (YA8679)(PBS only)* C12orf26	IHC-P	Human
	C12orf26 (METTL25) Antibody (YA8679) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C12orf26 (METTL25).

HY-P86598

	METTL3 Antibody (YA6290) N6-adenosine-methyltransferase 70 kDa subunit; MT-A70; Methyltransferase-like protein 3;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	METTL3 Antibody (YA6290) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to METTL3.