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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
MTP inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "MTP inhibitor" in MCE Product Catalog:
7
7 Cited Publications
Synonyms: AEGR-733; BMS-201038
Research Areas:
Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
7
7 Cited Publications
Synonyms: AEGR-733 mesylate; BMS-201038 mesylate
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8 + T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia .
Synonyms: AEGR 427
Research Areas:
Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.
Research Areas:
SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia .
Research Areas:
CP-346086 is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 can lower plasma cholesterol and triglycerides in vivo .
Cat. No.: HY-100333
CAS No.: 863491-70-7
Research Areas:
PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.
Cat. No.: HY-U00070
CAS No.: 481658-94-0
Synonyms: CP742033; Slentrol
Research Areas:
Dirlotapide (CP742033) is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs.
Cat. No.: HY-119220
CAS No.: 594842-13-4
Synonyms: JTT-130
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Granotapide is an orally active microsomal triglyceride transfer protein (MTP) inhibitor. Granotapide reduces the absorption of cholesterol and triglycerides by inhibiting MTP. Granotapide can be used in the research of coronary artery disease, obesity, diabetes mellitus and hypertension .
Cat. No.: HY-177291
CAS No.: 256397-11-2
Research Areas:
LAB687 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.9 nM for apolipoprotein B (apoB) secretion in HepG2 cells. LAB687 also acts as a Smoothened (Smo) antagonist, with IC50 values of 2.48 μM and 3.42 μM against mouse and human Smo receptors, respectively. LAB687 reduces triglyceride and low-density lipoprotein cholesterol (LDL-C) levels, and inhibits the Hedgehog signaling pathway. LAB687 can be used in studies related to Hedgehog-dependent cancers .
Cat. No.: HY-113955A
CAS No.: 1262769-98-1
Research Areas:
CP-346086 dihydrate is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 dihydrate can lower plasma cholesterol and triglycerides in vivo .
Cat. No.: HY-U00270
CAS No.: 186390-35-2
Research Areas:
CP-319340 free base is a microsomal triglyceride transfer protein (MTP) inhibitor.
Cat. No.: HY-U00329
CAS No.: 177277-99-5
Research Areas:
Implitapide Racemate is the racemate of Implitapide. Implitapide is a microsomal triglyceride transfer protein (MTP) inhibitor.
Cat. No.: HY-116630
CAS No.: 403989-79-7
Synonyms: JNJ-16269110
Research Areas:
Usistapide (JNJ-16269110) is a microsomal triglyceride transfer protein (MTP) inhibitor. Usistapide is promising for research of obesity .
Cat. No.: HY-14667R
CAS No.: 182431-12-5
Synonyms: AEGR-733 (Standard); BMS-201038 (Standard)
Research Areas:
Lomitapide (Standard) is the analytical standard of Lomitapide. This product is intended for research and analytical applications. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
Cat. No.: HY-155785
CAS No.: 2377372-62-6
Research Areas:
MTP is a PKM2 inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases ROS generation. MTP also inhibits JAK2 signaling. MTP can be used for research of oral squamous cell carcinoma .
Cat. No.: HY-14667S
CAS No.: 2459377-96-7
Synonyms: AEGR-733-d8; BMS-201038-d8
Cat. No.: HY-14668R
CAS No.: 202914-84-9
Synonyms: AEGR-733 mesylate (Standard); BMS-201038 mesylate (Standard)
Research Areas:
Lomitapide (mesylate) (Standard) is the analytical standard of Lomitapide (mesylate). This product is intended for research and analytical applications. Lomitapide (AEGR-733; BMS-201038) mesylate is a highly effective MTP protein inhibitor with an in vitro IC50 value of 8nM.
Cat. No.: HY-14667S1
CAS No.: 857296-42-5
Synonyms: AEGR-733-d4; BMS-201038-d4
Cat. No.: HY-106011R
CAS No.: 913541-47-6
Research Areas:
SLX-4090 (Standard) is the analytical standard of SLX-4090 (HY-106011). This product is intended for research and analytical applications. SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia .
Cat. No.: HY-187769
CAS No.: 913541-44-3
Target:
Research Areas:
KD026-metabolite (compound 5) serves as a synthetic intermediate for the preparation of compounds that inhibit microsomal triglyceride transfer protein (MTP) and apolipoprotein B (Apo B) secretion. KD026-metabolite can be used to synthesize MTP and Apo B secretion inhibitors, which are applied in research on related diseases such as atherosclerosis, hypertriglyceridemia and obesity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
