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CP-346086 

Cat. No.: HY-113955
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CP-346086 is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 can lower plasma cholesterol and triglycerides in vivo.

For research use only. We do not sell to patients.

CP-346086 Chemical Structure

CP-346086 Chemical Structure

CAS No. : 186390-48-7

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Description

CP-346086 is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 can lower plasma cholesterol and triglycerides in vivo[1].

IC50 & Target

IC50: 2.0 nM (MTP)[1]

In Vitro

CP-346086 (0.1-1000 nM) dose-dependently inhibits human MTP-mediated triglyceride transfer between vesicles with an IC50 of 2.0 nM[1].
CP-346086 (24 h) inhibits apolipoprotein B (apoB) and triglyceride secretion (IC50=2.6 nM) from Hep-G2 cells without affecting apoA-I secretion or lipid synthesis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CP-346086 (1-100 mg/kg; oral gavage once daily for 2 weeks) reduces plasma total, VLDL, and LDL cholesterol and triglycerides in mice[1].
CP-346086 (25 mg/kg; a single p.o.) results in an almost complete inhibition of Tyloxapol-induced triglyceride accumulation in fasted rats[1].
CP-346086 (0.1-10 mg/kg; a single p.o.) reduces acute plasma triglyceride in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B6CBAF1J mice[1]
Dosage: 1, 2, 10, 20, 100 mg/kg
Administration: Oral gavage once daily for 2 weeks
Result: Lowered total, VLDL, and LDL cholesterol and triglycerides dose dependently with 23%, 33%, 75%, and 62% reductions at 10 mg/kg/day.
Molecular Weight

477.48

Formula

C₂₆H₂₂F₃N₅O

CAS No.
SMILES

O=C(C1=CC=CC=C1C2=CC=C(C(F)(F)F)C=C2)NC3=CC4=C(CN(CC5=NC=NN5)CC4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CP-346086CP346086CP 346086OthersmicrosomaltriglyceridetransferproteinMTPcholesteroltriglyceridesInhibitorinhibitorinhibit

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CP-346086
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HY-113955
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