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Cat. No.: HY-116630

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Usistapide

Name: Usistapide
Brand: MedChemExpress
SKU: HY-116630
Availability: PreOrder

(Synonyms: JNJ-16269110)

Usistapide is a microsomal triglyceride transfer protein (MTP)-targeting agent; MTP is an essential chaperone transferring lipids including triacylglycerols and phospholipids.Usistapide can be used for the research of obesity.

For research use only. We do not sell to patients.

CAS No.: 403989-79-7
Formula: C₃₄H₃₁F₃N₂O₃
Molecular Weight:572.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Usistapide Chemical Structure

CAS No.: 403989-79-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Usistapide is a microsomal triglyceride transfer protein (MTP)-targeting agent; MTP is an essential chaperone transferring lipids including triacylglycerols and phospholipids^[1].Usistapide can be used for the research of obesity^[1].

In Vitro

Usistapide is a selective intestinal MTP inhibitor. MTP is a key molecular chaperone highly expressed in the intestine and liver, transporting triglycerides and phospholipids during lipoprotein assembly; Usistapide reduces triglyceride absorption without affecting hepatic MTP activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Metabolic Diseases

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS No. 403989-79-7
Molecular Weight 572.62
Formula C₃₄H₃₁F₃N₂O₃
SMILES

O=C(C1=CC=CC=C1C2=CC=C(C=C2)C(F)(F)F)NC3=CC=C(C=C3)C4CCN(CC4)[C@@H](C5=CC=CC=C5)C(OC)=O
Synonyms

JNJ-16269110
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jakab, J., Smolić, R., Včev, A., & Smolić, M. (2018). Drug Treatment of Obesity: From Bench to Bedside. In Drug Discovery - Concepts to Market. InTech.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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