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PF-02575799 

Cat. No.: HY-100333
Handling Instructions

PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.

For research use only. We do not sell to patients.

PF-02575799 Chemical Structure

PF-02575799 Chemical Structure

CAS No. : 863491-70-7

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.

IC50 & Target

IC50: 0.77±0.29 nM (MTP)[1]

In Vitro

PF-02575799 is compound 13 from the reference[1].

In Vivo

PF-02575799 produces appreciable triglyceride effects at its minimally effective dose (10 mg/kg). PF-02575799 significant increase alanine transaminase at 100 mg/kg[1].

References
Animal Administration
[1]

Rats[1]

Spray-dried dispersions formulated PF-02575799 is tested in a seven-day rat model. Food intake, body weight, liver TG, as well as serum alanine transaminase (ALT) are measured. In the definitive study, dose effect relationships are examined (PF-02575799 1, 3, 10, 30 and 100 mg/kg q.d.) and systemic exposures are measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

680.77

Formula

C₄₂H₃₇FN₄O₄

CAS No.

863491-70-7

SMILES

O=C(C1=CC=C2N=C(NC(C3=CC=CC=C3C4=CC=C(OC(C)C)C=C4)=O)C=CC2=C1)N[[email protected]@H](C5=CC=CC=C5)C(N(CC6=CC=C(F)C=C6)C)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PF-02575799
Cat. No.:
HY-100333
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PF-02575799

Cat. No.: HY-100333