256397-11-2
Chemical Structure
LAB687
- CAS No.: 256397-11-2
- Formula:C26H23F3N2O3
- Molecular Weight:468.47
IUPAC Name: methyl (R)-(5-(6-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)-2,3-dihydro-1H-inden-2-yl)carbamate
InChIKey: JKHYOWBRQRJSTQ-OAQYLSRUSA-N
SMILES: COC(N[C@@H]1CC2=CC=C(C=C2C1)NC(C(C=CC=C3C)=C3C4=CC=C(C(F)(F)F)C=C4)=O)=O
Biological Activity: LAB687 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.9 nM for apolipoprotein B (apoB) secretion in HepG2 cells. LAB687 also acts as a Smoothened (Smo) antagonist, with IC50 values of 2.48 μM and 3.42 μM against mouse and human Smo receptors, respectively. LAB687 reduces triglyceride and low-density lipoprotein cholesterol (LDL-C) levels, and inhibits the Hedgehog signaling pathway. LAB687 can be used in studies related to Hedgehog-dependent cancers[1][2][3].
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LAB687 | LAB687 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.9 nM for apolipoprotein B (apoB) secretion in HepG2 cells. LAB687 also acts as a Smoothened (Smo) antagonist, with IC50 values of 2.48 μM and 3.42 μM against mouse and human Smo receptors, respectively. LAB687 reduces triglyceride and low-density lipoprotein cholesterol (LDL-C) levels, and inhibits the Hedgehog signaling pathway. LAB687 can be used in studies related to Hedgehog-dependent cancers. | |||||||||||||||||||||
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References
- [1]. Peukert S, et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorg Med Chem Lett. 2009;19(2):328-331. [Content Brief]
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[2]. Mahavir Prashad, et al. Process Research and Development of a MTP Inhibitor: Another Case of
Disappearing Polymorphs upon Scale-up. Organic Process Research & Development 2010, 14, 878-882. - [3]. Shmeis RA, et al. A mechanistic investigation of an amorphous pharmaceutical and its solid dispersions, part I: a comparative analysis by thermally stimulated depolarization current and differential scanning calorimetry. Pharm Res. 2004;21(11):2025-2030. [Content Brief]
