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Results for "

NAMPT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NAMPT (76) ADC Payload (1) Akt (1) AMPK (2) Apoptosis (20) ATP Synthase (1) ATTECs (1) Autophagy (8) Biochemical Assay Reagents (1) Carbonic Anhydrase (1) Caspase (2) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (3) Drug Derivative (1) Drug Intermediate (1) Drug-Linker Conjugates for ADC (6) E1/E2/E3 Enzyme (1) Endogenous Metabolite (3) Epigenetic Reader Domain (1) ERK (3) GLUT (1) HDAC (3) IMPDH (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isocitrate Dehydrogenase (IDH) (2) Isotope-Labeled Compounds (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (2) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) mTOR (3) NF-κB (1) p38 MAPK (2) PAK (1) PARP (2) PD-1/PD-L1 (2) PDGFR (1) Phosphodiesterase (PDE) (1) PROTACs (6) Quinone Reductase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (4) Sirtuin (1) Small Interfering RNA (siRNA) (3) Target Protein Ligand-Linker Conjugates (1) TMV (1)
By Research Areas:	Cancer (76) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (9) Metabolic Disease (7) Neurological Disease (12)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: NAMPT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-F0004

Fosribnicotinamide 25+ Cited Publications β-Nicotinamide mononucleotide; β-NM; NMN	Endogenous Metabolite	Neurological Disease Cancer
Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD ⁺ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-50876

Daporinad Maximum Cited Publications 64 Publications Verification FK866; APO866	NAMPT Autophagy Apoptosis mTOR p38 MAPK ERK	Cancer
Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a K_i value of 0.3 nM. Daporinad depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad can be used for the study of myeloma, liver cancer, and immunosuppression .

HY-152154

Nampt degrader-2	PROTACs NAMPT	Cancer
Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades *NAMPT* with an IC₅₀ of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system (UPS). Nampt degrader-2 leads to significant reduction of NAD ⁺ and exerts potent antitumor activities .

HY-147193

Nampt-IN-10 TFA	NAMPT	Cancer
Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase *(NAMPT)* inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC₅₀s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs .

HY-136241

OT-82 1 Publications Verification	NAMPT Caspase	Cancer
OT-82 is a potent, selective and orally active inhibitor of *NAMPT. OT-82 is selectively toxic to cells of hematopoietic origin and?induces cell death in a NAD ⁺ dependent manner. OT-82 is a promising antineoplastic agent* for the study of hematological malignancies .

HY-126255

SBI-797812 2 Publications Verification	NAMPT	Metabolic Disease
SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts *NAMPT* to NMN formation, increases *NAMPT* affinity for ATP, stabilizes phosphorylated *NAMPT*, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD ⁺. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD ⁺ in mice .

HY-12793

Padnarsertib 3 Publications Verification KPT-9274	PAK NAMPT	Cancer
Padnarsertib (KPT-9274) is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC₅₀s of <100 nM and 120 nM, respectively .

HY-10079

CHS-828 4 Publications Verification GMX1778	NAMPT Apoptosis	Cancer
CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC₅₀ less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD ⁺ and exhibits a potent anticancer activity .

HY-18728

STF-31 15+ Cited Publications	GLUT Autophagy	Cancer
STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1 μM. STF-31 is also a *NAMPT* inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells .

HY-144776

NAT 4 Publications Verification	NAMPT	Cancer
NAT is an initial hit of *NAMPT* activator with an EC₅₀ of 5.7 μM and a K_D of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases .

HY-15766

GNE-617 5+ Cited Publications	NAMPT	Metabolic Disease Cancer
GNE-617 is a specific *NAMPT* inhibitor that inhibits the biochemical activity of NAMPT with an IC₅₀ of 5 nM and exhibits efficacy in xenograft models of cancer.

HY-157421

Nampt activator-4	NAMPT	Metabolic Disease
Nampt activator-4 is an orally active *NAMPT* activator, with an EC₅₀ of 58 nM and a K_a of 85.38 nM against human NAMPT. Nampt activator-4 effectively relieves the feedback inhibition of nicotinamide and NAD ⁺, thereby enhancing enzymatic activity and significantly increasing intracellular NAD ⁺ levels. Nampt activator-4 exhibits moderate stability in human and mouse liver microsomes. Nampt activator-4 shows low to moderate inhibitory effects on cytochrome P450 (especially CYP3A4). Nampt activator-4 can be used for the research of type 2 diabetes and related metabolic disorders .

HY-112615

NAMPT inhibitor-linker 1	Drug-Linker Conjugates for ADC	Cancer
NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC, composed of an *NAMPT* inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC₅₀s of <3 pM and 9 pM, respectively.

HY-148815

Nampt activator-1	NAMPT	Metabolic Disease
Nampt activator-1 is a nicotinamide phosphoribosyltransferase (NAMPT) activator, with an EC₅₀ of 3.3~3.7 μM. Nampt activator-1 enhances the enzymatic activity of *NAMPT. Nampt* activator-1 can be used for research related to metabolic disorders .

HY-402237

Nampt-IN-15	NAMPT	Neurological Disease Cancer
Nampt-IN-15 (Example 3) is an *Nampt* inhibitor. Nampt-IN-15 shows cytotoxicity against BxPC-3, HepG2, L540cy and MOLM-13, with IC₅₀s of 38.5 nM, 8 nM, 8.5 nM, 7 nM respectively .

HY-148948

Nampt activator-3	NAMPT	Neurological Disease
NAMPT activator-3, a NAT derivative, is a *NAMPT* activator with an EC₅₀ of 2.6 μM and a K_D of 132 nM. NAMPT activator-3 effectively protects cultured cells from FK866 (HY-50876)-mediated toxicity. NAMPT activator-3 exhibits strong neuroprotective efficacy in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model without any overt toxicity .

HY-12808

STF-118804 2 Publications Verification	NAMPT AMPK mTOR	Cancer
STF-118804 is a highly specific *NAMPT* inhibitor. STF-118804 activates AMPK and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer .

HY-F0004S

Fosribnicotinamide-d4 β-Nicotinamide mononucleotide-d₄; β-NM-d₄; NMN-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Cancer
Fosribnicotinamide-d₄ (β-Nicotinamide mononucleotide-d₄) is the deuterium labeled Fosribnicotinamide. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-12971

Nampt-IN-1 2 Publications Verification LSN3154567	NAMPT	Cancer
Nampt-IN-1 (LSN3154567) is a potent and selective *NAMPT* inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC₅₀ of 3.1 nM.

HY-148822

Nampt activator-2	NAMPT	Neurological Disease
Nampt activator-2 (compound 34) is a potent *NAMPT* activator, with EC₅₀ of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM) .

HY-112616

NAMPT inhibitor-linker 2	NAMPT Drug-Linker Conjugates for ADC	Cancer
NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an *NAMPT* inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC₅₀s of <7 pM and 40 pM, respectively.

HY-14373

CB30865 ZM 242421	NAMPT	Cancer
CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC₅₀ values in the 1-10 nM range) . CB30865 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-12628

GNE-618 2 Publications Verification	NAMPT	Cancer
GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC₅₀ of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity .

HY-P990319

ALT-100 (Human IgG4)	NAMPT	Inflammation/Immunology
ALT-100 (Human IgG4) is a humanized antibody expressed in CHO, targeting *NAMPT*. ALT-100 (Human IgG4) consists of a huIgG1/huIgG4 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For inflammatory or fibrotic diseases, the isotype control for ALT-100 (Human IgG4) can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-N3225

Myricanol	NAMPT Sirtuin Microtubule/Tubulin Apoptosis Autophagy PDGFR NF-κB AMPK	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Myricanol is a diarylheptanoid and a *Nampt* activator. Myricanol exerts anti-inflammatory effects and alleviates glucocorticoid-induced muscle atrophy by increasing Sirtuin 1 (SIRT1) and PRDX5 activities while regulating inflammatory factors. Myricanol exhibits growth inhibition and induces apoptosis in human lung adenocarcinoma A549 cells. Myricanol promotes autophagy-mediated clearance of microtubule-associated protein tau to exert neuroprotective effects. Myricanol protects cardiovascular function by inhibiting PDGFRβ and NF-κB signaling pathways. Myricanol activates mitochondrial transcription factor A (TFAM) expression to exert anti-renal fibrosis effects. Myricanol improves insulin resistance through AMPK activation .

HY-W017463

trans-3-(3-Pyridyl)acrylic acid	Drug Intermediate TMV Isocitrate Dehydrogenase (IDH)	Infection
trans-3-(3-Pyridyl) acrylic acid is an unsaturated carboxylic acid and synthetic building block, which serves as a synthetic precursor of 3-(3-pyridyl) propanoic acid. trans-3-(3-Pyridyl) acrylic acid can be used to prepare dual mutant *IDH1/NAMPT* inhibitors and PGE₂ antagonist analogs. In addition, trans-3-(3-Pyridyl) acrylic acid exhibits antiviral activity against tobacco mosaic virus (TMV) .

HY-P991075

ALT-100 (Human IgG1)	NAMPT	Inflammation/Immunology
ALT-100 (Human IgG1) is a humanized IgG1 monoclonal antibody that targets *NAMPT*. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-14374

GPP78 CAY10618	NAMPT Autophagy	Inflammation/Immunology Cancer
GPP78 (CAY10618) is a potent *Nampt* inhibitor with an IC₅₀ of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC₅₀ of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects .

HY-108701

Nampt-IN-3	NAMPT HDAC Autophagy Apoptosis	Cancer
Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC₅₀s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death .

HY-10080

Teglarinad chloride GMX1777; EB-1627	NAMPT	Cancer
Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis .

HY-162269

Nampt activator-5	NAMPT	Inflammation/Immunology
Nampt activator-5 is a *NAMPT* activator with a K_D value of 6.19 μM. Nampt activator-5 activates the rate-limiting enzyme in NAD ⁺ biosynthesis and promotes NAD ⁺ production. Nampt activator-5 delays the senescence process of senescent hepatocytes, extends the lifespan of Caenorhabditis elegans, and alleviates age-related dysfunction and abnormal biomarkers in naturally aged mice. Nampt activator-5 can be used in aging research .

HY-33287

2-Bromothiazole-5-carboxylic acid	Biochemical Assay Reagents	Cancer
2-Bromothiazole-5-carboxylic acid is a starting compound in the synthesis of active compounds. 2-Bromothiazole-5-carboxylic acid can be used in the synthesis of NAMPT/HDAC inhibitors. 2-Bromothiazole-5-carboxylic acid can be used in the research of colon cancer, lung cancer, and liver cancer .

HY-F0004R

Fosribnicotinamide (Standard) β-Nicotinamide mononucleotide (Standard); β-NM (Standard); NMN (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease Cancer
Fosribnicotinamide (Standard) (β-Nicotinamide mononucleotide (Standard)) is the analytical standard of Fosribnicotinamide (HY-F0004 ). This product is intended for research and analytical applications. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD ⁺ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-163499

NAMPT activator-7	NAMPT	Cancer
NAMPT activator-7 (Compound 232) is an activator for nicotinamide phosphoribosyltransferase (NAMPT), with EC₅₀ < 0.5 μM. NAMPT activator-7 activates NAMPT in cells U2OS with cellular EC₅₀ of < 0.5 μM .

HY-163500

NAMPT activator-8	NAMPT	Cancer
NAMPT activator-8 (Compound 278) is an activator for nicotinamide phosphoribosyltransferase (NAMPT), with EC₅₀ < 0.5 μM. NAMPT activator-8 activates NAMPT in cells U2OS with cellular EC₅₀ of < 0.5 μM .

HY-163445

NAMPT activator-6	NAMPT	Cancer
NAMPT activator-6 is a NAMPT activator, a regulatory molecule for the optical control system of NAMPT and NAD+. NAMPT activator-6 can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) to achieve up-down reversible regulation of NAMPT and NAD+ in a light-dependent manner and reduce the toxicity associated with inhibitor-based PS-PROTACs. PS-PROTAC can be used to achieve antitumor activity, NAMPT, and NAD+ modulation in vivo via optical manipulation .

HY-155506

NAMPT degrader-3	NAMPT	Cancer
NAMPT degrader-3 (compound C5) is a NAMPT degrader, depending on VHL- and proteasome manner. NAMPT degrader-3 displays cytotoxicity and inhibits A2780 cells proliferation .

HY-147193A

Nampt-IN-10 trihydrochloride	NAMPT	Cancer
Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines with IC₅₀ values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC) .

HY-RS09016

NAMPT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NAMPT Human Pre-designed siRNA Set A contains three designed siRNAs for NAMPT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NAMPT Human Pre-designed siRNA Set A NAMPT Human Pre-designed siRNA Set A

HY-125147

A-1293201	NAMPT	Cancer
A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD ⁺/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828 (HY-10079) .

HY-163440

*PROTAC NAMPT* Degrader-1**	PROTACs NAMPT	Cancer
PROTAC NAMPT Degrader-1 is a potent PROTAC targeting NAMPT with aDC₅₀ value of 217 nM. PROTAC NAMPT Degrader-1 has anti-proliferative activity with an IC₅₀ value of 0.12μM against A2780 cells. (Structure Note: PINK, NAMPT activator (HY-163445); Blue, VHL ligand (HY-163440); Black, linker) .

HY-164759

Nampt-IN-13	NAMPT	Cancer
Nampt-IN-13 (example 58m) is a *NAMPT* inhibitor that can be used in the synthesis of Antibody-drug Conjugate (ADC) .

HY-W1117786

Nampt-IN-10	ADC Payload NAMPT	Cancer
Nampt-IN-10 (Compound 4) is an efficient inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). Nampt-IN-10 exhibits nanomolar-level inhibitory activity against cell lines such as MDA-MB453, NCI-N87, and NCI-H526. Nampt-IN-10 can be used as an ADC payload, and the ADC constructed with it as the core demonstrates significant anti-tumor activity .

HY-163280

JGB-1-155	NAMPT	Neurological Disease
JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase *NAMPT* with EC₅₀ of 3.29 μM. JGB-1-155 counteracts the oxidative stress, through upregulating the NAD ⁺ in THP-1 human monocytes. JGB-1-155 attenuates TNFα-induced ROS in HT-22 cells .

HY-161712

IMPDH-IN-4	IMPDH	Cancer
IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers .

HY-130606

Nampt-IN-5	NAMPT Cytochrome P450	Cancer
Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC₅₀s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively .

HY-15766A

GNE-617 hydrochloride 5+ Cited Publications	NAMPT	Cancer
GNE-617 hydrochloride is a specific *NAMPT* inhibitor that inhibits the biochemical activity of NAMPT with an IC₅₀ of 5 nM and exhibits efficacy in xenograft models of cancer.

HY-172919

*PDEδ/NAMPT* IN-1**	Phosphodiesterase (PDE) NAMPT Apoptosis	Cancer
PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (K_D=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC₅₀=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD ⁺), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer .

HY-147838

Nampt-IN-9	NAMPT	Cancer
Nampt-IN-9 (Compound 8) is a potent *NAMPT* inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research .

HY-147656

NAMPT degrader-1	ATTECs NAMPT Autophagy	Cancer
NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC₅₀ of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990319

ALT-100 (Human IgG4)	NAMPT	Inflammation/Immunology
ALT-100 (Human IgG4) is a humanized antibody expressed in CHO, targeting *NAMPT*. ALT-100 (Human IgG4) consists of a huIgG1/huIgG4 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For inflammatory or fibrotic diseases, the isotype control for ALT-100 (Human IgG4) can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991075

ALT-100 (Human IgG1)	NAMPT	Inflammation/Immunology
ALT-100 (Human IgG1) is a humanized IgG1 monoclonal antibody that targets *NAMPT*. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990322

AMG-811	Inhibitory Antibodies	Inflammation/Immunology
AMG-811 is a CHO expressed human antibody that targets IFNg. AMG-811 carries a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for AMG-811 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-F0004

Fosribnicotinamide 25+ Cited Publications β-Nicotinamide mononucleotide; β-NM; NMN	Human Gut Microbiota Metabolites Microorganisms Other disease Neurological Disease Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD ⁺ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-N3225

Myricanol	Myrica ceriferaL. Phenols Polyphenols Plants Source Classification Myricaceae	NAMPT Sirtuin Microtubule/Tubulin Apoptosis Autophagy PDGFR NF-κB AMPK
Myricanol is a diarylheptanoid and a *Nampt* activator. Myricanol exerts anti-inflammatory effects and alleviates glucocorticoid-induced muscle atrophy by increasing Sirtuin 1 (SIRT1) and PRDX5 activities while regulating inflammatory factors. Myricanol exhibits growth inhibition and induces apoptosis in human lung adenocarcinoma A549 cells. Myricanol promotes autophagy-mediated clearance of microtubule-associated protein tau to exert neuroprotective effects. Myricanol protects cardiovascular function by inhibiting PDGFRβ and NF-κB signaling pathways. Myricanol activates mitochondrial transcription factor A (TFAM) expression to exert anti-renal fibrosis effects. Myricanol improves insulin resistance through AMPK activation .

HY-F0004R

Fosribnicotinamide (Standard) β-Nicotinamide mononucleotide (Standard); β-NM (Standard); NMN (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Fosribnicotinamide (Standard) (β-Nicotinamide mononucleotide (Standard)) is the analytical standard of Fosribnicotinamide (HY-F0004 ). This product is intended for research and analytical applications. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD ⁺ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

Species:	Human (2) Mouse (2)
Tag:	SUMO (1) His (2) Strep (1) Tag Free (1) GST (1) Flag (1)
Source:	Sf9 insect cells (1) P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701314

	NAMPT Protein, Mouse 3 Publications Verification rHuNicotinamide phosphoribosyltransferase/NAMPT, His; Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; NAMPT; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1	Mouse	E. coli
	NAMPT protein has dual functions of cytokine and adipokine. Due to limited ATP activation, its secreted form lacks enzymatic activity. It catalyzes the condensation of nicotinamide and 5-phosphoribosyl-1-pyrophosphate to produce nicotinamide mononucleotide, which is critical for NAD biosynthesis. NAMPT Protein, Mouse is the recombinant mouse-derived NAMPT protein, expressed by E. coli , with tag free.

HY-P701315

	NAMPT Protein, Mouse (P.pastoris, His) rHuNicotinamide phosphoribosyltransferase/NAMPT, His; Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; NAMPT; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1	Mouse	P. pastoris
	NAMPT protein has dual functions of cytokine and adipokine. Due to limited ATP activation, its secreted form lacks enzymatic activity. It catalyzes the condensation of nicotinamide and 5-phosphoribosyl-1-pyrophosphate to produce nicotinamide mononucleotide, which is critical for NAD biosynthesis. NAMPT Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived NAMPT protein, expressed by P. pastoris , with N-10*His labeled tag.

HY-P70353

	NAMPT Protein, Human (His) 4 Publications Verification rHuNicotinamide phosphoribosyltransferase/NAMPT, His; Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; NAMPT; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1	Human	E. coli
	NAMPT protein catalyzes the synthesis of nicotinamide mononucleotide, a key intermediate in NAD biosynthesis. NAMPT Protein, Human (His) is the recombinant human-derived NAMPT protein, expressed by E. coli , with N-6*His labeled tag.

HY-P704014

	NAMPT Protein, Human (sf9, His, GST) rHuNicotinamide phosphoribosyltransferase/NAMPT, His; Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; NAMPT; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1	Human	Sf9 insect cells
	NAMPT protein catalyzes the synthesis of nicotinamide mononucleotide, a key intermediate in NAD biosynthesis. NAMPT Protein, Human (sf9, His, GST) is the recombinant human-derived NAMPT protein, expressed by Sf9 insect cells, with N-His and N-GST labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-F0004S

Fosribnicotinamide-d4

Fosribnicotinamide-d₄ (β-Nicotinamide mononucleotide-d₄) is the deuterium labeled Fosribnicotinamide. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Mouse (2) Rat (2) Monkey (2) Rabbit (2)
Application:	IHC-P (4) ICC/IF (2) WB (2) FC (2) ELISA (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85319

	Visfatin Antibody (YA5011) NAMPT; PBEF; PBEF1; Nicotinamide phosphoribosyltransferase; NAmPRTase; NAMPT; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Mouse, Monkey, Rabbit
	Visfatin Antibody (YA5011) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Visfatin.

HY-P85319A

	Visfatin Antibody (YA5011)(PBS only) NAMPT; PBEF; PBEF1; Nicotinamide phosphoribosyltransferase; NAmPRTase; NAMPT; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Mouse, Monkey, Rabbit
	Visfatin Antibody (YA5011) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Visfatin.

HY-P81438

	Visfatin Antibody (YA1183) Nicotinamide phosphoribosyltransferase; NAmPRTase; NAMPT; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin	IHC-P	Human
	Visfatin Antibody (YA1183) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Visfatin.

HY-P81438A

	Visfatin Antibody (YA1183)(PBS only) Nicotinamide phosphoribosyltransferase; NAmPRTase; NAMPT; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin	IHC-P	Human
	Visfatin Antibody (YA1183) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Visfatin.