1. Metabolic Enzyme/Protease
    Antibody-drug Conjugate/ADC Related
  2. Nampt
    Drug-Linker Conjugates for ADC
  3. NAMPT inhibitor-linker 1

NAMPT inhibitor-linker 1 

Cat. No.: HY-112615
Handling Instructions

NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.

For research use only. We do not sell to patients.

NAMPT inhibitor-linker 1 Chemical Structure

NAMPT inhibitor-linker 1 Chemical Structure

CAS No. : 2241019-57-6

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Description

NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.

In Vitro

ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <3 pM and 9 pM, respectively[1].

In Vivo

ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells[1].

Animal Model: Female scid-beige (SCID bg) mice[1]
Dosage: 20 mg/kg
Administration: A single intravenous injection (i.v.) for 28 days
Result: Significantly inhibited the growth of tumor in mice.
Molecular Weight

668.71

Formula

C₃₆H₃₇FN₆O₆

CAS No.

2241019-57-6

SMILES

FC1=CC(NC([[email protected]@H]2[[email protected]](C2)C3=CN=CC=C3)=O)=CC=C1CNC(C4=CC=C(N5CCN(C(CCOCCN6C(C=CC6=O)=O)=O)CC5)C=C4)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NAMPT inhibitor-linker 1
Cat. No.:
HY-112615
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