2847156-05-0
Chemical Structure
Nampt activator-4
- CAS No.: 2847156-05-0
- Formula:C26H22F3N7OS
- Molecular Weight:537.56
InChIKey: PNEQDEPNUMZDMO-NRFANRHFSA-N
SMILES: O=C([C@@H]1CN(CCN1)C2=NC=NC3=NN(C=C32)C4=CC=C(C=C4)C(F)(F)F)NCC5=CC=C6SC=CC6=C5
Biological Activity: Nampt activator-4 is an orally active NAMPT activator, with an EC50 of 58 nM and a Ka of 85.38 nM against human NAMPT. Nampt activator-4 effectively relieves the feedback inhibition of nicotinamide and NAD+, thereby enhancing enzymatic activity and significantly increasing intracellular NAD+ levels. Nampt activator-4 exhibits moderate stability in human and mouse liver microsomes. Nampt activator-4 shows low to moderate inhibitory effects on cytochrome P450 (especially CYP3A4). Nampt activator-4 can be used for the research of type 2 diabetes and related metabolic disorders[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nampt activator-4 | 98.87% | Nampt activator-4 is an orally active NAMPT activator, with an EC50 of 58 nM and a Ka of 85.38 nM against human NAMPT. Nampt activator-4 effectively relieves the feedback inhibition of nicotinamide and NAD+, thereby enhancing enzymatic activity and significantly increasing intracellular NAD+ levels. Nampt activator-4 exhibits moderate stability in human and mouse liver microsomes. Nampt activator-4 shows low to moderate inhibitory effects on cytochrome P450 (especially CYP3A4). Nampt activator-4 can be used for the research of type 2 diabetes and related metabolic disorders. | ||||||||||||||||||||
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