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NCI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Adenosine Receptor (1) Akt (3) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (3) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (39) ATM/ATR (2) ATTECs (1) Aurora Kinase (3) Autophagy (3) Bacterial (8) Bcl-2 Family (3) Biochemical Assay Reagents (1) c-Met/HGFR (1) c-Myc (4) Carbonic Anhydrase (2) Caspase (5) CCR (2) CD38 (1) CDK (6) Checkpoint Kinase (Chk) (1) COX (2) Cytochrome P450 (2) Deubiquitinase (1) Dihydroorotate Dehydrogenase (2) Discoidin Domain Receptor (2) DNA Alkylator/Crosslinker (6) DNA/RNA Synthesis (4) Drug Derivative (5) Drug-Linker Conjugates for ADC (2) EGFR (17) Endogenous Metabolite (4) Epigenetic Reader Domain (2) ERK (6) Estrogen Receptor/ERR (1) FAK (1) Ferroptosis (4) FGFR (3) FLT3 (1) Fluorescent Dye (1) Fungal (5) Glutaminase (1) Glutathione Peroxidase (1) GSK-3 (1) HCV (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (2) HSP (6) IAP (1) IFNAR (1) IGF-1R (1) IKZF Family (1) JAK (1) Keap1-Nrf2 (1) Kinesin (1) Lactate Dehydrogenase (1) Lipoxygenase (1) MAPKAPK2 (MK2) (1) MASTL (1) MDM-2/p53 (1) Microtubule/Tubulin (11) Mitochondrial Metabolism (1) Molecular Glues (1) Monocarboxylate Transporter (1) mTOR (2) Mucin (1) Na+/K+ ATPase (1) NAMPT (2) Necroptosis (1) NF-κB (3) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (1) p97 (1) Parasite (6) PARP (4) PDGFR (1) Phosphatase (3) Phosphodiesterase (PDE) (1) PI3K (3) PROTAC Linkers (2) PROTACs (13) Raf (1) Ras (10) Reactive Oxygen Species (ROS) (8) Reference Standards (6) RIBOTAC (1) ROR (1) ROS Kinase (1) Ser/Thr Protease (1) SHP2 (2) SNIPERs (1) SOS1 (3) SphK (2) Src (1) STAT (3) SWI/SNF Complex (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (3) Transmembrane Glycoprotein (1) Trk Receptor (2) TrxR (1) Tyrosinase (1) VEGFR (3) Wee1 (2) Wnt (3) Xanthine Oxidase (1) YAP (6) β-catenin (3)
By Research Areas:	Cancer (163) Endocrinology (4) Infection (14) Inflammation/Immunology (8) Neurological Disease (1)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (4)
Oligonucleotides:	Phospholipids (1)

175

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148517

AZD0095 4 Publications Verification	Monocarboxylate Transporter	Cancer
AZD0095 is a selective and orally active MCT4 inhibitor (IC₅₀: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205) .

HY-132295

Azenosertib 4 Publications Verification ZN-c3	Wee1	Cancer
Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC₅₀=3.9 nM). Azenosertib exhibits antitumor activity .

HY-101130

PNU-74654 Maximum Cited Publications 11 Publications Verification	Wnt β-catenin Apoptosis	Cancer
PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC₅₀ of 129.8 μM in NCI-H295 cell.

HY-101567

BMS-986158 3 Publications Verification	Epigenetic Reader Domain	Cancer
BMS-986158 is a potent BET inhibitor with IC₅₀s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively .

HY-N0840

Bruceantin 2 Publications Verification (-)-Bruceantin; NCI165563; NSC165563	c-Myc Caspase Mitochondrial Metabolism Apoptosis Parasite	Infection Cancer
Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities .

HY-147858

PROTAC EGFR degrader 7	PROTACs EGFR Apoptosis	Cancer
PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFR ^L858R/T790M degrader, with a DC₅₀ of 13.2 nM. PROTAC EGFR degrader 7 inhibits NCI–H1975 cells proliferation, with an IC₅₀ of 46.82 nM. PROTAC EGFR degrader 7 significantly induces apoptosis and G2/M phase arrest in NCI–H1975 cell. PROTAC EGFR degrader 7 shows antitumor activity, and can be used for non-small cell lung cancer (NSCLC) research . PROTAC EGFR degrader 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1161

True Blue NCI 240899	Fluorescent Dye	Neurological Disease
True Blue (NCI 240899) is a fluorescent dye, as neuronal retrograde tracer (excitation wavelength 395-425 nm, barrier filter 450 nm). True Blue can label neuron and has no effects on neuronal survival .

HY-149265

ROS-generating agent 1	Reactive Oxygen Species (ROS) TrxR Ferroptosis Apoptosis	Cancer
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities .

HY-176798

NCI-006	Lactate Dehydrogenase Reactive Oxygen Species (ROS) Apoptosis	Cancer
NCI-006 is an orally active lactate dehydrogenase (LDH) inhibitor (LDHA IC₅₀ = 0.06 μM; LDHB IC₅₀ = 0.03 μM). NCI-006 inhibits intratumoral LDH activity, lactate production, and tumor growth in a mouse pancreatic cancer model. NCI-006 inhibits glycolysis and induces apoptosis in vitro. NCI-006 enhances the radiosensitivity of glycolytic tumor cell lines while sparing non-glycolytic/normal cells (1522, skin fibroblasts) in combination with ionizing radiation (IR). NCI-006 exhibits synergistic antitumor effects in combination with IACS-010759 (HY-112037) against colorectal and gastric cancers. NCI-006 targets glycolysis by inhibiting lactate dehydrogenase impairs tumor growth in an Ewing sarcoma model .

HY-176557

NCI677397	Deubiquitinase Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase Autophagy	Cancer
NCI677397 is a USP24 inhibitor. NCI677397 increases lipid ROS, activates cholesterol and fatty acid biosynthesis, degrades ABC transporters, GPX4 and DHFR through the autophagy pathway, decreases the level of P-gp and ultimately leads to ferroptosis in drug-resistant cancer cells. NCI677397 can be used for the study of lung caner and brain cancer .

HY-N2039

20(R)-Ginsenoside Rg2	Others	Cancer
20(R)-Ginsenoside Rg2 shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities .

HY-100555

CH5138303	HSP	Infection Cancer
CH5138303 is a potent and orally active Hsp90 inhibitor. CH5138303 shows high binding affinity for N-terminal Hsp90α, with K_d of 0.52 nM. CH5138303 shows potent anti-proliferative activity against human cancer cell lines (HCT116 and NCI-N87), with IC₅₀ values of 0.098 and 0.066 μM, respectively. CH5138303 shows high oral bioavailability in mice (F=44.0%). CH5138303 shows potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model .

HY-147208

MSC-4106	YAP	Cancer
MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model .

HY-156215

NCI-B16	HCV	Infection
NCI-B16 is a small molecule RNA binder and inhibits HCV viral replication .

HY-19797

ML241	p97	Cancer
ML241 is a potent, selective and competitive p97 ATPase inhibitor with an IC₅₀ of 0.11 μM. ML241 can be used for the research of cancer .

HY-116505

JAK1-IN-4	JAK	Cancer
JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC₅₀s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC₅₀, 227 nM) .

HY-W779529

Cerberin 2'-Acetylneriifolin	Na+/K+ ATPase	Cancer
Cerberin is a cardiac glycoside that has been found in C. odollam and has cytotoxic and cardiac modulatory activities. It is cytotoxic to KB and NCI H187 cancer cells (IC₅₀s=1.92 and 1.24 μg/mL).1 Cerberin inhibits Na+/K+-ATPase, increasing intracellular sodium levels and action potential duration in cardiac cells.

HY-164384

DFX117	PI3K Akt mTOR Apoptosis	Cancer
DFX117 is a selective, orally active inhibitor for PI3Kα and c-Met tyrosine kinase. DFX117 inhibits PI3K/Akt/mTOR pathway, inhibits the proliferation of NCI-H1975, NCI-H1993, and HCC827 with IC₅₀s 0.02-0.08 µM. DFX117 arrests cell cycle at G0/G1 phase, induces apoptosis in A549 and NCI-H1975. DFX117 exhibits antitumor efficacy in mice .

HY-156060

NCI126224	Toll-like Receptor (TLR)	Inflammation/Immunology
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases .

HY-U00095

Hepsulfam 2 Publications Verification NCI 329680; ZINC01574758	DNA Alkylator/Crosslinker	Cancer
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC₅₀ of 0.91 μg/mL in a panel of different tumors.

HY-171958

PROTAC EGFR degrader 12	PROTACs EGFR	Cancer
PROTAC EGFR degrader 12 (example 1) is a PROTAC degrader targeting EGFR that can effectively degrade EGFR mutants, but has little effect on EGFR WT. PROTAC EGFR degrader 12 shows IC_{50_{s against EGFR ^L858R-T790M (NCI-H1975 cells), EGFR ^L858R (NCI-H3255 cells), and EGFR ^{L858R-T790M-L797S} (NCI-H1975+CS cells) of all <50 nM .}}

HY-W1117786

Nampt-IN-10	ADC Payload NAMPT	Cancer
Nampt-IN-10 (Compound 4) is an efficient inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). Nampt-IN-10 exhibits nanomolar-level inhibitory activity against cell lines such as MDA-MB453, NCI-N87, and NCI-H526. Nampt-IN-10 can be used as an ADC payload, and the ADC constructed with it as the core demonstrates significant anti-tumor activity .

HY-178242

PROTAC EGFR degrader 16	PROTACs EGFR	Cancer
PROTAC EGFR degrader 16 (Compound 98) a selective EGFR PROTAC degrader with DC₅₀ values of < 50 nM in NCI-H1975 (EGFR L858R-T970M), NCI-H3225 (EGFR L858R) and NCI-H1976 + CS (EGFR L858R-T970M-L797S). PROTAC EGFR degrader 16 can be used for the study of EGFR-driven cancerssuch as non-small cell lung cancer (Pink: EGFR ligand (HY-178313); Blue: CRBN ligand (HY-W1128702); Black: Linker; EGFR ligand + Linker (HY-178311)) .

HY-179403

KRASG12C IN-17	Ras	Cancer
KRASG12C IN-17 is an orally active covalent KRAS ^G12C inhibitor, showing strong inhibitory activity in KRAS ^G12C-mutant cancer cells (NCI-H23 IC₅₀ = 0.7 nM; NCI-H358 IC₅₀ = 0.5 nM). KRASG12C IN-17 covalently and irreversibly binds to KRAS ^G12C with > 96% modification efficiency in both GDP-bound and GMPPNP-bound conformations. KRASG12C IN-17 can be used for studies of KRAS-driven cancers, including colorectal cancer .

HY-157673

1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine 16:1 PE	Phosphatase Apoptosis	Cancer
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance PP2A and PTP1B activities in malignant pleural mesothelioma cells. 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis of NCI-H28 malignant pleural mesothelioma cells .

HY-U00095R

Hepsulfam (Standard) NCI 329680 (Standard); ZINC01574758 (Standard)	DNA Alkylator/Crosslinker Reference Standards	Cancer
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC50 of 0.91 μg/mL in a panel of different tumors.

HY-U00155

NCI172112 NSC172112; NSC268497	DNA Alkylator/Crosslinker	Cancer
NCI172112 is a classical bifunctional alkylating agent synthesized in an effort to develop antitumor agents effective against CNS tumors.

HY-160129

Centanamycin ML-970; AS-I-145; NSC 716970	Nucleoside Antimetabolite/Analog	Cancer
Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI₅₀ of 34 nM in NCI-60 cell line screening .

HY-172426

Dirozalkib	Anaplastic lymphoma kinase (ALK)	Cancer
Dirozalkib (Compound 4) is the inhibitor for ALK with an IC₅₀ of 0.9 nM. Dirozalkib exhibits anti-proliferative activity in cancer cells NCI-H3122, Karpas-299 and NCI-H2228 with IC₅₀s of 130.4, 0.71 and 15.11 nM, respectively. Dirozalkib exhibits good pharmacokinetics characteristics with an bioavailbility of 30%~50% .

HY-W056098

tert-Butyl N-[cis-3-(aminomethyl)cyclobutyl]carbamate	PROTAC Linkers	Cancer
tert-Butyl N-[cis-3-(aminomethyl)cyclobutyl]carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-170764

M3686	YAP	Cancer
M3686 (Compound 29) is a potent, selective TEAD1 inhibitor with an IC₅₀ value of 51 nM. M3686 also shows weaker binding activity on TEAD3. M3686 potently inhibits cell viability against YAP-dependent NCI-H226 cell line with an IC₅₀ value of 0.06 uM. M3686 shows strong anti-tumor effects in the NCI-H226 xenograft model .

HY-147703

Aurora kinase inhibitor-9	Aurora Kinase	Cancer
Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B dual aurora kinase inhibitor with IC₅₀s of 0.093, 0.09 µM for Aurora A, Aurora B, respectively. Aurora kinase inhibitor-9 shows broad spectrum anti-proliferative activity .

HY-173259

PARP7-IN-23	PARP	Cancer
PARP7-IN-23 (compound 56) is a potent PARP7 inhibitor with an EC₅₀ of 0.915 nM for pSTAT1 in NCI-H1373 cells. PARP7-IN-23 has the potential for cancer research .

HY-173262

PARP7-IN-24	PARP	Cancer
PARP7-IN-24 (compound 44) is a potent PARP7 inhibitor with an EC₅₀ of 0.375 nM for pSTAT1 in NCI-H1373 cells. PARP7-IN-24 has the potential for cancer research .

HY-178941

DHODH-IN-32	Dihydroorotate Dehydrogenase Apoptosis Caspase Reactive Oxygen Species (ROS)	Cancer
DHODH-IN-32 (Compound A1) is a DHODH inhibitor. DHODH-IN-32 shows significant cytotoxicity against NCI-60 cell lines, especially being sensitive to breast cancer, prostate cancer and leukemia cell lines. DHODH-IN-32 can induce cell apoptosis by activating the Caspase pathway. DHODH-IN-32 causes G0/G1 phase cell cycle arrest and inhibits cellular metabolism by ROS. DHODH-IN-32 exhibits significant anti-tumor properties in mouse breast cancer models. DHODH-IN-32 can be used for the study of breast cancer .

HY-157085

BX-2819	HSP	Cancer
BX-2819 is a Hsp90 inhibitor with an IC₅₀ value of 41 nM. BX-2819 inhibits the proliferation of cancer cells. BX-2819 can significantly inhibit the growth of NCI-N87 and HT-29 tumors in nude mice .

HY-170912

Topo I/II-IN-2	Topoisomerase Apoptosis ROS Kinase Cytochrome P450 Caspase Bcl-2 Family PI3K Akt mTOR	Cancer
Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC₅₀s of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer) cell proliferation, invasion, and migration in vitro. .

HY-176538

Antiproliferative agent-72	HSP	Cancer
Antiproliferative agent-72 (Compound 10) is a Hsp90 inhibitor with a K_d of 11 nM. Antiproliferative agent-72 has antiproliferative activity with IC₅₀s of 1.5  μM and 1.1 μM for HCT116 and NCI-N87 cells, respectively. Antiproliferative agent-72 can be used for cancers research .

HY-157522

NCI-14465	Phosphodiesterase (PDE)	Cancer
NCI-14465 is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) inhibitor with an IC 50 of 26.4 μM. NCI-14465 can be used in cancer research .

HY-U00155R

NCI172112 (Standard) NSC172112 (Standard); NSC268497 (Standard)	Reference Standards DNA Alkylator/Crosslinker	Cancer
NCI172112 is a classical bifunctional alkylating agent synthesized in an effort to develop antitumor agents effective against CNS tumors.

HY-163000

EGFR-IN-129	EGFR	Cancer
EGFR-IN-129 (Compound 10b) is a potent and selective EGFR inhibitor, with an IC₅₀ of 51.2 nM. EGFR-IN-129 exhibits broadest-spectrum antiproliferative activity against the NCI-tumor panel .

HY-N14255

Memnobotrin A	Antibiotic Bacterial	Infection Cancer
Memnobotrin A is an antibiotic found in Memnoniella echinata (JS6308). Memnobotrin A has inhibitory effect on NCI-460, MCF7 and SF-268 cell lines .

HY-123597

NSC 109555 DDUG; NCI C04808	Autophagy Checkpoint Kinase (Chk)	Cancer
NSC 109555 is an ATP-competitive inhibitor of checkpoint kinase 2 (Chk2; IC₅₀=200 nM in a cell-free kinase assay). It is selective for Chk2 over Chk1 and 16 kinases in a panel but does inhibit Brk, c-Met, IGFR, and LCK with IC₅₀ values of 210, 6,000, 7,400, and 7,100 nM, respectively. NSC 109555 inhibits Chk2 autophosphorylation and phosphorylation of the Chk2 substrate histone H1 in vitro (IC₅₀=240 nM). It inhibits the growth of, and induces autophagy in, L1210 leukemia cells in vitro.2 NSC 109555 (1,250 nM) potentiates gemcitabine-induced cytotoxicity in MIA PaCa-2, CFPAC-1, PANC-1, and BxPC-3 pancreatic cancer cells, as well as reduces gemcitabine-induced increases in Chk2 phosphorylation and enhances gemcitabine-induced production of reactive oxygen species (ROS) in MIA PaCa-2 cells.

HY-N14280

Memnobotrin B	Antibiotic Bacterial	Infection Cancer
Memnobotrin B is an antibiotic found in Memnoniella echinata (JS6308). Memnobotrin B has inhibitory effect on NCI-460, MCF7 and SF-268 cell lines .

HY-125730

Kibdelone A	Others	Cancer
Kibdelone A is a type of natural compound from the flavonoid family, and it has potential value as an anti-proliferative agent .

HY-N3443

Jolkinol A	Others	Cancer
Jolkinol A is a natural product that can be found in Euphorbia pubescens. Jolkinol A inhibits cell growth with GI₅₀s of 95.3, 57.3, >100 µM for MCF-7, NCI-460, SF-268 cells, respectively .

HY-147724

Microtubule inhibitor 3	Microtubule/Tubulin	Cancer
Compounds 17O (ic₅₀= 14.0 nm, NCI-H460) and 17p (ic₅₀= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

HY-147728

Microtubule inhibitor 7	Microtubule/Tubulin	Cancer
Compounds 17O (ic₅₀= 14.0 nm, NCI-H460) and 17p (ic₅₀= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

HY-168093

Cetzole	Ferroptosis	Cancer
Cetzole (Compound 1) is a ferroptosis inducer that induces cell death through ROS accumulation. The CC₅₀ values of Cetzole for NCI-H522, NCI-H522 GFP-SCL7A11 #8, NCI-H522 RV-GFP, HT-1080, NARF2, and MDA-MB-231 are 2.56, 10.31, 2.71, 3.07, 14.9, and 6.28 μM, respectively. Cetzole holds potential for research in the field of cancer .

HY-N10307

Anserinone B	Fungal Bacterial Endogenous Metabolite	Infection Cancer
Anserinone B is an antifungal and antibacterial benzoquinone. Anserinone B causes radial growth reductions of 50% and 37% against S.fimicola and A. furfuraceus, respectively. Anserinones B also displays moderate cytotoxicity in the NCI’s 60 human tumor cell line panel (GI₅₀=4.4 µg/mL) .

Cat. No.	Product Name	Type

HY-177442

DS-3939a

DS-3939

Fluorescent Dye

DS-3939a (DS-3939) is an anti-TA-MUC1 (tumor-associated mucin-1) antibody-drug conjugate (ADC). DS-3939a consists of a humanized anti-TA-MUC1 IgG1 monoclonal antibody Gatipotuzumab ( HY-P99634), a stable and cleavable tetrapeptide-based linker (Gly-Gly-Phe-Gly), and a DNA topoisomerase I inhibitor payload (DXd) (HY-13631D), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). DS-3939a inhibits the growth of TA-MUC1-positive cancer cells (CFPAC-1, NCI-H2110) by inducing DNA damage and apoptosis. DS-3939a exhibits significant antitumor activity in a variety of TA-MUC1-expressing advanced solid tumors. DS-3939a can be used for the study of TA-MUC1-expressing advanced cancers .

HY-D1161

True Blue NCI 240899	Fluorescent Dye
True Blue (NCI 240899) is a fluorescent dye, as neuronal retrograde tracer (excitation wavelength 395-425 nm, barrier filter 450 nm). True Blue can label neuron and has no effects on neuronal survival .

Cat. No.	Product Name	Target	Research Area

HY-P2055

A-57696	Endogenous Metabolite	Endocrinology
A-57696 is a cholecystokinin antagonist with selective activity at cortical CCK-B receptors (IC50 = 25 nM). A-57696 behaves as a competitive antagonist in reversing CCK8-stimulated pancreatic alpha-amylase secretion and phosphatidylinositol degradation. A-57696 fails to induce gallbladder contraction and inhibits CCK8-induced contraction. A-57696 behaves as a partial agonist at CCK-B/gastrin receptors on NCI-H345 cells, achieving 80% of the maximal CCK8 response. A-57696 and CCK8 inhibit each other in a calcium mobilization assay .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990506

*Anti-Siglec-2/CD22 Antibody (NCI* m971)** NCI m971	Inhibitory Antibodies	Inflammation/Immunology
Anti-Siglec-2/CD22 Antibody (NCI m971) is a humanized antibody expressed in CHO cells that targets Siglec-2/CD22. Anti-Siglec-2/CD22 Antibody (NCI m971) features a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 146.64 kDa. The isotype control for Anti-Siglec-2/CD22 Antibody (NCI m971) can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991462

GBR-1342	CD38	Cancer
GBR-1342 is a human bispecific antibody (bsAb) targeting CD38 & CD3. GBR-1342 inhibits the activity of Daudi, RAJI, RPMI8226, IM-9, and NCI-H929 cancer cell lines. GBR-1342 can be used in myeloma research .

HY-P990507

*Anti-Siglec-2/CD22 Antibody (NCI* m972)** NCI m972	Inhibitory Antibodies	Inflammation/Immunology
The Anti-Siglec-2/CD22 Antibody (NCI m972) is a humanized antibody expressed in CHO, targeting Siglec-2/CD22. The Anti-Siglec-2/CD22 Antibody (NCI m972) has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 144.3 kDa. The isotype control for Anti-Siglec-2/CD22 Antibody (NCI m972) can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name		Classification

HY-147858

PROTAC EGFR degrader 7		Alkynes PROTAC Synthesis
PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFR ^L858R/T790M degrader, with a DC₅₀ of 13.2 nM. PROTAC EGFR degrader 7 inhibits NCI–H1975 cells proliferation, with an IC₅₀ of 46.82 nM. PROTAC EGFR degrader 7 significantly induces apoptosis and G2/M phase arrest in NCI–H1975 cell. PROTAC EGFR degrader 7 shows antitumor activity, and can be used for non-small cell lung cancer (NSCLC) research . PROTAC EGFR degrader 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-179403

KRASG12C IN-17		Alkynes
KRASG12C IN-17 is an orally active covalent KRAS ^G12C inhibitor, showing strong inhibitory activity in KRAS ^G12C-mutant cancer cells (NCI-H23 IC₅₀ = 0.7 nM; NCI-H358 IC₅₀ = 0.5 nM). KRASG12C IN-17 covalently and irreversibly binds to KRAS ^G12C with > 96% modification efficiency in both GDP-bound and GMPPNP-bound conformations. KRASG12C IN-17 can be used for studies of KRAS-driven cancers, including colorectal cancer .

HY-168093

Cetzole		Alkynes
Cetzole (Compound 1) is a ferroptosis inducer that induces cell death through ROS accumulation. The CC₅₀ values of Cetzole for NCI-H522, NCI-H522 GFP-SCL7A11 #8, NCI-H522 RV-GFP, HT-1080, NARF2, and MDA-MB-231 are 2.56, 10.31, 2.71, 3.07, 14.9, and 6.28 μM, respectively. Cetzole holds potential for research in the field of cancer .

HY-159119

hDHODH-IN-15		Alkynes
hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC₅₀ of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC₅₀ of 0.95-2.81 µM. hDHODH-IN-15 induces ferroptosis in HCT-116, and exhibits antitumor efficacy .

Cat. No.	Product Name		Classification

HY-157673

1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine 16:1 PE		Phospholipids
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance PP2A and PTP1B activities in malignant pleural mesothelioma cells. 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis of NCI-H28 malignant pleural mesothelioma cells .

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