907547-06-2
907547-06-2
Chemical Structure
NCI677397
- CAS No.: 907547-06-2
- Formula:C28H31N3OS
- Molecular Weight:457.63
InChIKey: YVRLVNJCHMOEHI-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2SC3=C(N(CCCCN4CCN(CC4)C)C2=C1)C=CC=C3)C5=CC=CC=C5
Biological Activity: NCI677397 is a USP24 inhibitor. NCI677397 increases lipid ROS, activates cholesterol and fatty acid biosynthesis, degrades ABC transporters, GPX4 and DHFR through the autophagy pathway, decreases the level of P-gp and ultimately leads to ferroptosis in drug-resistant cancer cells. NCI677397 can be used for the study of lung caner and brain cancer[1][2].
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NCI677397 | NCI677397 is a USP24 inhibitor. NCI677397 increases lipid ROS, activates cholesterol and fatty acid biosynthesis, degrades ABC transporters, GPX4 and DHFR through the autophagy pathway, decreases the level of P-gp and ultimately leads to ferroptosis in drug-resistant cancer cells. NCI677397 can be used for the study of lung caner and brain cancer. | |||||||||||||||||||||
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References
Keywords
