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Pathways Recommended:	Metabolic Enzyme/Protease

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NEDD8-activating Enzyme

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NEDD8-activating Enzyme (10) Apoptosis (7) Carbonic Anhydrase (2) Microtubule/Tubulin (1) PROTACs (1) Reference Standards (3) STAT (1)
By Research Areas:	Cancer (13)

13

Inhibitors & Agonists

1

Recombinant Proteins

5

Antibodies

Targets Recommended: NEDD8-activating Enzyme Peroxidase Enzyme E1/E2/E3 Enzyme Carnosine-cleaving Enzyme Proteolytic Enzyme Endothelin-Converting Enzyme (ECE) Angiotensin-converting Enzyme (ACE) IRE1 IDE TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Pevonedistat Maximum Cited Publications 212 Publications Verification MLN4924	NEDD8-activating Enzyme Apoptosis	Cancer
Pevonedistat (MLN4924) is a potent and selective **NEDD8-activating enzyme (NAE) inhibitor with an IC₅₀ of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis** of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice .

TAS4464 5+ Cited Publications	Apoptosis Carbonic Anhydrase NEDD8-activating Enzyme	Cancer
TAS4464 is a long-acting, highly selective covalent inhibitor targeting *NEDD8*-activating enzyme (NAE) (IC₅₀=0.955 nM), and also inhibits CAII with an IC₅₀ of 0.73 μM, which is less potent than MLN4924 (HY-70062). The IC₅₀ values of TAS4464 against other E1 enzymes UAE and SAE are 449 nM and 1280 nM, respectively. TAS4464 targets *NEDD8* in an ATP-dependent manner to inhibit NAE, blocks the neddylation pathway, causes accumulation of CRL ubiquitin ligase substrates (such as CDT1, p27, phosphorylated IκBα), and further induces tumor cell apoptosis. TAS4464 exhibits antiproliferative and cytotoxic effects, and has broad-spectrum antitumor activity against various hematologic and solid tumor cell lines as well as patient-derived tumor cells. TAS4464 has a wide selcetive window, without obvious toxicity. TAS4464 can be used in the research of hematologic malignancies (leukemia, lymphoma, multiple myeloma, etc.) and solid tumors (small cell lung cancer, colorectal cancer, sarcoma, endometrial cancer, ovarian cancer, etc.) .

Pevonedistat hydrochloride Maximum Cited Publications 212 Publications Verification MLN4924 hydrochloride	NEDD8-activating Enzyme Apoptosis	Cancer
Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC₅₀ of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice .

TAS4464 hydrochloride 5+ Cited Publications	NEDD8-activating Enzyme Carbonic Anhydrase Apoptosis	Cancer
TAS4464 hydrochloride is a long-acting, highly selective covalent inhibitor targeting *NEDD8*-activating enzyme (NAE) (IC₅₀=0.955 nM), and also inhibits CAII with an IC₅₀ of 0.73 μM, which is less potent than MLN4924 (HY-70062). The IC₅₀ values of TAS4464 hydrochloride against other E1 enzymes UAE and SAE are 449 nM and 1280 nM, respectively. TAS4464 hydrochloride targets *NEDD8* in an ATP-dependent manner to inhibit NAE, blocks the neddylation pathway, causes accumulation of CRL ubiquitin ligase substrates (such as CDT1, p27, phosphorylated IκBα), and further induces tumor cell apoptosis. TAS4464 hydrochloride exhibits antiproliferative and cytotoxic effects, and has broad-spectrum antitumor activity against various hematologic and solid tumor cell lines as well as patient-derived tumor cells. TAS4464 hydrochloride has a wide therapeutic window, without obvious toxicity. TAS4464 hydrochloride can be used in the research of hematologic malignancies (leukemia, lymphoma, multiple myeloma, etc.) and solid tumors (small cell lung cancer, colorectal cancer, sarcoma, endometrial cancer, ovarian cancer, etc.) .

NAE-IN-3	NEDD8-activating Enzyme	Cancer
NAE-IN-3 (compound 1) is a potent, selective and non-covalent competitive NEDD8-activating enzyme (NAE) inhibitor (IC₅₀ = 0.8 μM). NAE-IN-3 inhibits NAE by blocking the ATP-binding domain. NAE-IN-3 exhibits selectivity over analogous E1 enzymes UAE and SAE. NAE-IN-3 can be used for cancer research .

ZM223 hydrochloride	NEDD8-activating Enzyme	Cancer
ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity .

NAE-IN-M22	Apoptosis	Cancer
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo .

Pevonedistat (Standard) MLN4924 (Standard)	NEDD8-activating Enzyme Apoptosis Reference Standards	Cancer
Pevonedistat (Standard) is the analytical standard of Pevonedistat. This product is intended for research and analytical applications. Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice .

ZM223	NEDD8-activating Enzyme	Cancer
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active .

Tubulin/NEDDylation-IN-1	Microtubule/Tubulin	Cancer
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC₅₀ for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .

Pevonedistat hydrochloride (Standard) MLN4924 hydrochloride (Standard)	Reference Standards NEDD8-activating Enzyme Apoptosis	Cancer
Pevonedistat hydrochloride (Standard) is the analytical standard of Pevonedistat hydrochloride (HY-10484). This product is intended for research and analytical applications. Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC₅₀ of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice .

HY-101790AR

ZM223 hydrochloride (Standard)	Reference Standards NEDD8-activating Enzyme	Cancer
ZM223 hydrochloride (Standard) is the analytical standard of ZM223 hydrochloride (HY-101790A). This product is intended for research and analytical applications. ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity .

SD-965	PROTACs STAT	Cancer
SD-965 is a selective STAT3 PROTAC degrader with a DC₅₀ of 0.14 μM. SD-965 promotes the ubiquitination and degradation of STAT3. SD-965 induces rapid, complete and persistent depletion of STAT3 protein. SD-965 induces tumor regression in mouse xenograft models of leukemia and lymphoma .

Cat. No.	Compare	Product Name	Species	Source	Image

	APPBP1-UBA3/NEDD8 E1 Protein, Human A-116A10.1; amyloid beta precursor protein binding protein 1; amyloid beta precursor protein binding protein 1, 59kDa; Amyloid beta precursor protein-binding protein 1, 59 kDa; amyloid beta precursor protein-binding protein 1, 59kD; Amyloid protein-binding protein 1; APPBP1APP-BP1; NEDD8 activating Enzyme E1 subunit 1; NEDD8-activating Enzyme E1 regulatory subunit; NEDD8-activating Enzyme E1 subunit; protooncogene protein 1; Proto-oncogene protein 1; ula-1	Human	E. coli
	The APPBP1-UBA3/NEDD8 E1 protein is the regulatory subunit in the UBA3-NAE1 E1 enzyme complex and activates NEDD8 by adenylating its C-terminal glycine with ATP. This forms the NEDD8-UBA3 thioester, which is transferred to the catalytic cysteine of UBE2M. APPBP1-UBA3/NEDD8 E1 Protein, Human is a recombinant protein dimer complex containing human-derived APPBP1-UBA3/NEDD8 E1 protein, expressed by E. coli , with tag free. APPBP1-UBA3/NEDD8 E1 Protein, Human, has molecular weight of 60 kDa (APP-BP1) 50 kDa (UBA3).

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Host:	Mouse (1) Rabbit (4)
Reactivity:	Human (5) Rat (3) Mouse (3)
Application:	IHC-P (1) ICC/IF (1) IP (2) WB (5)
Isotype:	IgG (4) IgG1 (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

	NEDD8 Activating Enzyme E1C Antibody (YA9707) DKFZp566J164, EC 6.3.2., hUba3, MGC22384, NEDD8 activating Enzyme E1 catalytic subunit, NEDD8 activating Enzyme E1C, NEDD8 activating Enzyme hUba3, NEDD8-activating Enzyme E1 catalytic subunit, NEDD8-activating Enzyme E1C, uba3	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	NEDD8 Activating Enzyme E1C Antibody (YA9707) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to NEDD8 Activating Enzyme E1C.

	NEDD8 Activating Enzyme E1C Antibody (YA3296) NAE2; UBE1C; hUBA3	WB	Human, Mouse, Rat
	NEDD8 Activating Enzyme E1C Antibody (YA3296) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NEDD8 Activating Enzyme E1C.

	NEDD8 Activating Enzyme E1C Antibody (YA3296)(PBS only) NAE2; UBE1C; hUBA3	WB	Human, Mouse, Rat
	NEDD8 Activating Enzyme E1C Antibody (YA3296) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NEDD8 Activating Enzyme E1C.

	APPBP1 Antibody (YA2131) NEDD8 activating Enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1	WB, IP	Human
	APPBP1 Antibody (YA2131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to APPBP1.

	APPBP1 Antibody (YA2131)(PBS only) NEDD8 activating Enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1	WB, IP	Human
	APPBP1 Antibody (YA2131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to APPBP1.

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