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  5. NEDD8 Activating Enzyme E1C Antibody (YA3296)

NEDD8 Activating Enzyme E1C Antibody (YA3296)

Cat. No.: HY-P83551
User Guide for Antibodies Technical Support

NEDD8 Activating Enzyme E1C Antibody (YA3296) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NEDD8 Activating Enzyme E1C.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

NEDD8 Activating Enzyme E1C Antibody (YA3296) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NEDD8 Activating Enzyme E1C.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 52 kDa;
Observed band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human UBA3
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:2000-1:5000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression
Expression：
Tissue_specificity:Ubiquitously expressed
Isoforms & Post-Translational Modification：Q8TBC4 has 2 isomers: Q8TBC4-1: 51852 Da (predicted); Q8TBC4-2: 50072 Da (predicted).
Subunit：Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroid ligand (By similarity). Interacts with TBATA (By similarity)
Database

Entrez Gene: 9039 Human ; 22200 Mouse ; 117553 Rat

SwissProt: Q8TBC4 Human ; Q8C878 Mouse ; Q99MI7 Rat

OMIM: 603172 Human

Research Field

Cell Biology
Synonyms
NAE2; UBE1C; hUBA3
Documentation
User Guide for Antibodies (1077 KB)

NEDD8 Activating Enzyme E1C Antibody (YA3296) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NEDD8 Activating Enzyme E1C Antibody (YA3296)
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