Search Result

Results for "

OTUB1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CFTR (4) Cyclic GMP-AMP Synthase (2) Deubiquitinase (8) DUBTACs (2) PROTACs (3) Small Interfering RNA (siRNA) (3) STING (2) Wee1 (4)
By Research Areas:	Cancer (11) Inflammation/Immunology (4) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151563

OTUB1/USP8-IN-1 2 Publications Verification	Deubiquitinase	Cancer
OTUB1/USP8-IN-1 is a potent dual *OTUB1/USP8* inhibitor with IC₅₀ values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer ^[1].

HY-143345

EN523	Deubiquitinase	Cancer
EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1 ^[1].

HY-151563A

OTUB1/USP8-IN-1 TFA 2 Publications Verification	Deubiquitinase	Cancer
OTUB1/USP8-IN-1 TFA is the TFA salt form of OTUB1/USP8-IN-1 (HY-151563). OTUB1/USP8-IN-1 TFA is a dual inhibitor for *OTUB1/USP8, IC₅₀* for OTUB1 and USP8 is 0.17 and 0.28 nM, respectively. OTUB1/USP8-IN-1 TFA inhibits proliferation of NSCLC cells. OTUB1/USP8-IN-1 TFA exhibits good pharmacokinetic characters in ICR mouse, and exhibits antitumor activity in H1975 xenograft mouse model ^[1].

HY-115878

NJH-2-057	CFTR	Others
NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

HY-143344

NJH-2-056	PROTACs CFTR	Inflammation/Immunology
NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research ^[1].

HY-144999

LEB-03-146	Wee1	Cancer
LEB-03-146 is a *WEE1* DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a PEG2 linker. LEB-03-146 shows significant *WEE1* stabilization in HEP3B hepatoma cancer cells ^[1].

HY-162966

MS7829	Cyclic GMP-AMP Synthase PROTACs STING	Cancer
MS7829 is a deubiquitinase-targeting chimera (DUBTAC) that targets cGAS. MS7829 recruits *OTUB1* to cGAS, binds covalently to *OTUB1, stabilizes the protein abundance of cGAS, and activates the cGAS-STING-IRF3* innate immune signaling pathway in an *OTUB1*-dependent manner. MS7829 is applicable to cancer-related research ^[1].

HY-RS23172

Otub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Otub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Otub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Otub1 Rat Pre-designed siRNA Set A Otub1 Rat Pre-designed siRNA Set A

HY-RS09869

OTUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
OTUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for OTUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

OTUB1 Human Pre-designed siRNA Set A OTUB1 Human Pre-designed siRNA Set A

HY-RS16735

Otub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Otub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Otub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Otub1 Mouse Pre-designed siRNA Set A Otub1 Mouse Pre-designed siRNA Set A

HY-143342

LEB-03-144	Wee1	Cancer
LEB-03-144 is a *WEE1* DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant *WEE1* stabilization in HEP3B hepatoma cancer cells ^[1].

HY-143343

LEB-03-153	Wee1	Cancer
LEB-03-153 is a *WEE1* DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through no linker ^[1].

HY-143340

LEB-03-145	Wee1	Cancer
LEB-03-145 is a *WEE1* DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C5 alkyl linker ^[1].

HY-183724

MS8572	Deubiquitinase	Inflammation/Immunology
MS8572 is a selective *OTUB1* covalent ligand. MS8572 covalently modifies the noncatalytic cysteine 23 residue of OTUB1 and does not inhibit OTUB1 deubiquitinase activity. MS8572 can be used for development of deubiquitinase-targeting chimeras for targeted protein stabilization ^[1].

HY-183725

MS5128	DUBTACs Deubiquitinase CFTR	Inflammation/Immunology
MS5128 is an OTUB1-based deubiquitinase-targeting chimera (DUBTAC) targeting CFTR. MS5128 recruits OTUB1 to CFTR to induce deubiquitination and stabilization of CFTR. MS5128 can be used for the research of cystic fibrosis ^[1]. (Blue: CFTR Ligand (HY-183724); Pink: OTUB1 Ligand (HY-13262); Black: Linker)

HY-185122

MS6178	CFTR Deubiquitinase	Cancer
MS6178 is a MS5105-based CFTR deubiquitinase-targeted chimera (DUBTAC) that recruits *OTUB1* to stabilize ΔF508-CFTR mutant protein in a concentration- and time-dependent manner, with an *OTUB1*-dependent effect and no impact on CFTR mRNA level. MS6178 can be used for the research of cancer ^[1].

HY-182350

FXR DUBTAC IN-1	DUBTACs Deubiquitinase	Metabolic Disease
FXR DUBTAC IN-1 (compound D11) is a deubiquitinase-targeting chimeric molecule (DUBTAC) that targets FXR, with a K_a value of 2.12e-5 M for FXR. FXR DUBTAC IN-1 recruits the deubiquitinase *OTUB1, binds to OTUB1* and forms a ternary complex with FXR, reduces the polyubiquitination level of FXR, prevents FXR degradation via the ubiquitin-proteasome pathway, and elevates the protein level of FXR. FXR DUBTAC IN-1 can be used in the research of cholestatic liver injury ^[1].

HY-175934

MS5105	Deubiquitinase	Cancer
MS5105 is a covalent ligand of the deubiquitinating enzyme *OTUB1*, which can be used to construct DUBTACs, such as MS8588 (HY-162967) ^[1].

HY-162967

MS8588	PROTACs Cyclic GMP-AMP Synthase STING	Inflammation/Immunology Cancer
MS8588 is a deubiquitinase-targeting chimera (DUBTAC) against cGAS. MS8588 induces targeted stabilization of cGAS, thereby activating downstream signaling pathways. MS8588 activates the cGAS/STING/IRF3 innate immune signaling pathway. MS8588 exhibits antitumor activity ^[1].

Recombinant Proteins Recommended:

OTUB1

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75952

	OTUB1 Protein, Human (His) Ubiquitin thioesterase OTUB1; OTUBain-1; OTUB1; OTB1; OTU1	Human	E. coli
	OTUB1 protein directly interacts with RNF128, forming a ternary complex with USP8 through OTUB1's binding to the C-terminal UCH catalytic domain of USP8. OTUB1 Protein, Human (His) is the recombinant human-derived OTUB1 protein, expressed by E. coli , with N-His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IP (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81738

	OTUB1 Antibody (YA1483) OTUB1; OTB1; OTU1; HSPC263; Ubiquitin thioesterase OTUB1; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTUBain-1; hOTU1; Ubiquitin-specific-processing protease OTUB1	WB, IP	Human, Mouse, Rat
	OTUB1 Antibody (YA1483) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to OTUB1.

HY-P81738A

	OTUB1 Antibody (YA1483)(PBS only) OTUB1; OTB1; OTU1; HSPC263; Ubiquitin thioesterase OTUB1; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTUBain-1; hOTU1; Ubiquitin-specific-processing protease OTUB1	WB, IP	Human, Mouse, Rat
	OTUB1 Antibody (YA1483) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to OTUB1.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Otub1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Otub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Otub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

OTUB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
OTUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for OTUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Otub1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Otub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Otub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy

Name
Email *

	Sorry, but the email address you supplied was invalid.