OTUB1/USP8-IN-1 TFA
Based on 3 publication(s) in Google Scholar
OTUB1/USP8-IN-1 TFA is the TFA salt form of OTUB1/USP8-IN-1 (HY-151563). OTUB1/USP8-IN-1 TFA is a dual inhibitor for OTUB1/USP8, IC50 for OTUB1 and USP8 is 0.17 and 0.28 nM, respectively. OTUB1/USP8-IN-1 TFA inhibits proliferation of NSCLC cells. OTUB1/USP8-IN-1 TFA exhibits good pharmacokinetic characters in ICR mouse, and exhibits antitumor activity in H1975 xenograft mouse model.
For research use only. We do not sell to patients.
- Purity: 99.56%
- Formula: C24H17ClF4N2O6
- Molecular Weight:540.85
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Ubiquitination Compound Library
HY-L050
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Anti-Lung Cancer Compound Library
HY-L075
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Metabolic Enzyme Compound Library
HY-L146
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Protease Inhibitor Library
HY-L147
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Publications Citing Use of MedChemExpress (MCE) OTUB1/USP8-IN-1 TFA
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Biological Activity
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USP8 0.28 nM (IC50) |
Chemical Information
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Appearance Solid
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Molecular Weight 540.85
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Formula C24H17ClF4N2O6
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Color Off-white to light yellow
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SMILES
O=C(C1=C2OC(C3=C(F)C=CC(O[C@H]4CN(C)CC4)=C3Cl)=N1)C5=C(C=CC=C5)C2=O.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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J Med Chem
Discovery of New OTUB1 Covalent Ligands via Structure-Activity Relationship Studies for Targeted Protein Stabilization. [Abstract]2026 May 14;69(9):10263-10277. PMID: 42083385 -
Biochem Pharmacol
OTUB1 enhances fatty acid oxidation in APAP-induced liver injury by mediating ACSL5 deubiquitination. [Abstract]2025 Jul:237:116957. PMID: 40280245 -
Sci Rep
4-Octyl itaconate alleviates sepsis-induced liver injury by regulating ferroptosis via the OTUB1/TRAF3 axis. [Abstract]2026 Feb 10;16(1):8201. PMID: 41667684
Solvent & Solubility
DMSO : 100 mg/mL (184.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8489 mL | 9.2447 mL | 18.4894 mL | 46.2235 mL |
| 5 mM | 0.3698 mL | 1.8489 mL | 3.6979 mL | 9.2447 mL | |
| 10 mM | 0.1849 mL | 0.9245 mL | 1.8489 mL | 4.6224 mL | |
| 15 mM | 0.1233 mL | 0.6163 mL | 1.2326 mL | 3.0816 mL | |
| 20 mM | 0.0924 mL | 0.4622 mL | 0.9245 mL | 2.3112 mL | |
| 25 mM | 0.0740 mL | 0.3698 mL | 0.7396 mL | 1.8489 mL | |
| 30 mM | 0.0616 mL | 0.3082 mL | 0.6163 mL | 1.5408 mL | |
| 40 mM | 0.0462 mL | 0.2311 mL | 0.4622 mL | 1.1556 mL | |
| 50 mM | 0.0370 mL | 0.1849 mL | 0.3698 mL | 0.9245 mL | |
| 60 mM | 0.0308 mL | 0.1541 mL | 0.3082 mL | 0.7704 mL | |
| 80 mM | 0.0231 mL | 0.1156 mL | 0.2311 mL | 0.5778 mL | |
| 100 mM | 0.0185 mL | 0.0924 mL | 0.1849 mL | 0.4622 mL |
OTUB1/USP8-IN-1 TFA Related Classifications
HY-151563A Related Classifications
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