305 Results for "

Post

" in MedChemExpress (MCE) Product Catalog:
Products (305)

305 Results for "Post" in MCE Product Catalog:

54
Raleukin
Raleukin
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54 Publications Verification
Cat. No.: HY-108841
CAS No.: 143090-92-0
Purity:  99.40%
Synonyms: Kineret; Anakinra

Target:  

Interleukin Related

Research Areas:  

Infection Inflammation/Immunology Cancer

Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction .
38
Bicuculline
Bicuculline
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38 Cited Publications
Cat. No.: HY-N0219
CAS No.: 485-49-4
Synonyms: (+)-Bicuculline
Category:  

Alkaloids Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae

Target:  

GABA Receptor

Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca 2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .
23
α-MSH
α-MSH
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23 Cited Publications
Cat. No.: HY-P0252
CAS No.: 581-05-5
Synonyms: α-Melanocyte-Stimulating Hormone
Target:  

Melanocortin Receptor

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology

α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC) .
23
α-MSH TFA
α-MSH TFA
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23 Cited Publications
Cat. No.: HY-P0252A
CAS No.: 171869-93-5
Synonyms: α-Melanocyte-Stimulating Hormone TFA
Target:  

Melanocortin Receptor

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology

α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC) .
18
Paroxetine
Paroxetine
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18 Cited Publications
Cat. No.: HY-122272
CAS No.: 61869-08-7
Purity:  99.92%
Synonyms: BRL29060
Target:  

Cytochrome P450 5-HT Receptor NO Synthase Apoptosis Serotonin Transporter Estrogen Receptor/ERR

Paroxetine (BRL29060) is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions .
18
Paroxetine hydrochloride
Paroxetine hydrochloride
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18 Cited Publications
Cat. No.: HY-B0492
CAS No.: 78246-49-8
Synonyms: BRL29060 hydrochloride; BRL29060A
Target:  

Cytochrome P450 5-HT Receptor NO Synthase Apoptosis Serotonin Transporter Estrogen Receptor/ERR

Paroxetine (BRL29060) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine hydrochloride inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine hydrochloride is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine hydrochloride is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions .
16
Yohimbine Hydrochloride
Yohimbine Hydrochloride
0 Images
16 Cited Publications
Cat. No.: HY-N0127
CAS No.: 65-19-0
Category:  

Alkaloids other families Plants Disease Research Fields Endocrinology Indole Alkaloids

Target:  

Adrenergic Receptor

Yohimbine hydrochloride is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis.
14
Sulfaphenazole
Sulfaphenazole
0 Images
14 Cited Publications
Cat. No.: HY-B1218
CAS No.: 526-08-9
Target:  

Cytochrome P450 Antibiotic Bacterial Necroptosis Apoptosis

Research Areas:  

Infection Cardiovascular Disease

Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion .
12
Cefazolin
Cefazolin
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12 Cited Publications
Cat. No.: HY-B1892
CAS No.: 25953-19-9
Synonyms: Cephazolin
Target:  

Antibiotic Bacterial

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research . Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) .
12
Cefazolin sodium
Cefazolin sodium
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12 Cited Publications
Cat. No.: HY-B1078
CAS No.: 27164-46-1
Synonyms: Cephazolin sodium
Target:  

Bacterial Antibiotic

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Cefazolin sodium is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research . Cefazolin sodium has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) .
7
Paroxetine maleate
Paroxetine maleate
0 Images
7 Cited Publications
Cat. No.: HY-110029
CAS No.: 64006-44-6
Synonyms: BRL29060 maleate
Target:  

Cytochrome P450 5-HT Receptor NO Synthase Apoptosis Serotonin Transporter Estrogen Receptor/ERR

Research Areas:  

Neurological Disease

Paroxetine maleate is a potent and selective inhibitor of SSRI. Paroxetine maleate is used in generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache research .
5
GSK3179106
GSK3179106
0 Images
5 Cited Publications
Cat. No.: HY-100459
CAS No.: 1627856-64-7
Purity:  98.41%
Target:  

RET

Research Areas:  

Metabolic Disease Inflammation/Immunology

GSK3179106 is an orally active and selective RET kinase inhibitor with IC50s of 0.4 nM, 0.2 nM for human RET and rat RET, respectively. GSK3179106 has the potential for irritable bowel syndrome (IBS) through the attenuation of post-inflammatory and stress-induced visceral hypersensitivity .
5
PTC299
PTC299
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5 Cited Publications
Cat. No.: HY-124593
CAS No.: 1256565-36-2
Purity:  99.89%
Synonyms: Emvododstat
Target:  

VEGFR Dihydroorotate Dehydrogenase DNA/RNA Synthesis

Research Areas:  

Cancer

PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies .
5
Acetyl Coenzyme A trisodium
Acetyl Coenzyme A trisodium
0 Images
5 Cited Publications
Cat. No.: HY-113596
CAS No.: 102029-73-2
Purity:  99.22%
Synonyms: Acetyl-CoA trisodium
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Oxidative Phosphorylation Endogenous Metabolite Autophagy

Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis .
5
Acetyl coenzyme A lithium
Acetyl coenzyme A lithium
0 Images
5 Cited Publications
Cat. No.: HY-113596A
CAS No.: 32140-51-5
Purity:  97%
Synonyms: Acetyl-CoA lithium
Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis .
5
Dehydroepiandrosterone sulfate
Dehydroepiandrosterone sulfate
0 Images
5 Cited Publications
Cat. No.: HY-113416
CAS No.: 651-48-9
Purity:  99.93%
Synonyms: DHEA sulfate; Prasterone sulfate
Category:  

Human Gut Microbiota Metabolites Microorganisms Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite

Target:  

GABA Receptor Sigma Receptor iGluR PPAR NF-κB

Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .
5
Dehydroepiandrosterone sulfate sodium
Dehydroepiandrosterone sulfate sodium
0 Images
5 Cited Publications
Cat. No.: HY-B0765
CAS No.: 1099-87-2
Synonyms: DHEA sulfate sodium; Prasterone sulfate sodium
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

GABA Receptor Sigma Receptor iGluR PPAR NF-κB

Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium salt has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium salt can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium salt participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium salt may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .
4
Emapunil
Emapunil
0 Images
4 Cited Publications
Cat. No.: HY-15527
CAS No.: 226954-04-7
Purity:  99.94%
Synonyms: AC-5216; XBD-173
Target:  

TSPO

Research Areas:  

Neurological Disease Metabolic Disease

Emapunil (AC-5216), an orally active and selective TSPO (a mitochondrial benzodiazepine receptor) ligand, produces anti-anxiety and antidepressant-like effects in various animal models .
4
Tropisetron Hydrochloride
Tropisetron Hydrochloride
0 Images
4 Cited Publications
Cat. No.: HY-B0020
CAS No.: 105826-92-4
Synonyms: SDZ-ICS-930
Target:  

5-HT Receptor nAChR

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Tropisetron Hydrochloride (SDZ-ICS-930) is an effective neuroprotective agent that acts as a 5-HT3 receptor antagonist, a calmodulin inhibitor, and an α7-nAChRreceptor agonist, with an IC50 of 70.1 nM for the 5-HT3 receptor. Tropisetron Hydrochloride has anti-inflammatory properties and immune-regulating functions, effectively alleviating symptoms associated with chemotherapy and post-surgery. Tropisetron Hydrochloride reduces Ab (HY-P4867)-induced hippocampal neuroinflammation .
3
Clesrovimab
Clesrovimab
0 Images
3 Cited Publications
Cat. No.: HY-P99804
CAS No.: 2429913-18-6
Synonyms: MK1654

Target:  

RSV

Research Areas:  

Infection

Clesrovimab (MK1654) is a humanized IgG1 monoclonal antibody targeting the respiratory syncytial virus (RSV) protein F. Clesrovimab binds to pre-fusion and post-fusion forms of RSV-A fusion protein with high affinity, with corresponding KD values of 71 pM and 480 pM, respectively. Clesrovimab is applicable for the research of RSV infection .
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