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QR2

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By Targets:	Autophagy (1) Bacterial (1) Cytochrome P450 (1) Keap1-Nrf2 (1) Monoamine Oxidase (1) Quinone Reductase (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Infection (1) Neurological Disease (2)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122614

S29434 2 Publications Verification NMDPEF	Autophagy	Neurological Disease
S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC₅₀s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production .

HY-144635

*Nrf2-ARE/hMAO-B/QR2* modulator 1**	Monoamine Oxidase Keap1-Nrf2 Reactive Oxygen Species (ROS)	Neurological Disease
Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC₅₀s of 8.05, 9.83 and 0.57 μM for hMAO-B, *NRF2* and *QR2. Nrf2-ARE/hMAO-B/QR2* modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices . Nrf2-ARE/hMAO-B/QR2 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N1066

Xanthohumol D 1 Publications Verification	Others	Cancer
Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC₅₀ value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro ^[2].

HY-N11855

Casimiroin	Quinone Reductase Cytochrome P450 Bacterial	Infection Cancer
Casimiroin is a *QR2* and Aromatase inhibitor, with an IC₅₀ of 54.1 μM against *QR2* and an IC₅₀ of 3.92 μM against aromatase. Casimiroin exhibits antimutagenic activity and inhibits DMBA (HY-W011845)-induced mutations in Salmonella typhimurium. Casimiroin suppresses DMBA-induced precancerous lesions in mouse mammary organ cultures. Casimiroin can be used in breast cancer-related research ^[2].

HY-RS09524

NQO2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NQO2 Human Pre-designed siRNA Set A contains three designed siRNAs for NQO2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NQO2 Human Pre-designed siRNA Set A NQO2 Human Pre-designed siRNA Set A

Xanthohumol D 1 Publications Verification	Flavonoids Chalcones Classification of Application Fields Humulus lupulus L. Phenols Polyphenols Plants Moraceae Disease Research Fields Source Classification Cancer	Others
Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC₅₀ value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro ^[2].

Casimiroin	Structural Classification Natural Products Ketones, Aldehydes, Acids Casimiroa edulis La Llave Rutaceae Plants Source Classification	Quinone Reductase Cytochrome P450 Bacterial
Casimiroin is a *QR2* and Aromatase inhibitor, with an IC₅₀ of 54.1 μM against *QR2* and an IC₅₀ of 3.92 μM against aromatase. Casimiroin exhibits antimutagenic activity and inhibits DMBA (HY-W011845)-induced mutations in Salmonella typhimurium. Casimiroin suppresses DMBA-induced precancerous lesions in mouse mammary organ cultures. Casimiroin can be used in breast cancer-related research ^[2].

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82542

	NQO2 Antibody (YA2287) QR2; DHQV; DIA6; NMOR2	WB, FC	Human, Mouse, Rat
	NQO2 Antibody (YA2287) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NQO2.

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Cat. No.	Product Name		Classification

HY-144635

*Nrf2-ARE/hMAO-B/QR2* modulator 1**		Alkynes
Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC₅₀s of 8.05, 9.83 and 0.57 μM for hMAO-B, *NRF2* and *QR2. Nrf2-ARE/hMAO-B/QR2* modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices . Nrf2-ARE/hMAO-B/QR2 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

NQO2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NQO2 Human Pre-designed siRNA Set A contains three designed siRNAs for NQO2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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