477-89-4
477-89-4
Chemical Structure
Casimiroin
- CAS No.: 477-89-4
- Formula:C12H11NO4
- Molecular Weight:233.22
IUPAC Name: 6-methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
InChIKey: DPXXJCMMMXZVSW-UHFFFAOYSA-N
SMILES: O=C1C=C(OC)C=2C=CC=3OCOC3C2N1C
Biological Activity: Casimiroin is a QR2 and Aromatase inhibitor, with an IC50 of 54.1 μM against QR2 and an IC50 of 3.92 μM against aromatase. Casimiroin exhibits antimutagenic activity and inhibits DMBA (HY-W011845)-induced mutations in Salmonella typhimurium. Casimiroin suppresses DMBA-induced precancerous lesions in mouse mammary organ cultures. Casimiroin can be used in breast cancer-related research[1][2].
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Casimiroin | Casimiroin is a QR2 and Aromatase inhibitor, with an IC50 of 54.1 μM against QR2 and an IC50 of 3.92 μM against aromatase. Casimiroin exhibits antimutagenic activity and inhibits DMBA (HY-W011845)-induced mutations in Salmonella typhimurium. Casimiroin suppresses DMBA-induced precancerous lesions in mouse mammary organ cultures. Casimiroin can be used in breast cancer-related research. | |||||||||||||||||||||
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References
- [1]. Maiti A, et al. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. Journal of medicinal chemistry. 2009 Apr 09;52(7):1873-84. [Content Brief]
- [2]. Wang M, et al. Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer. Steroids. 2010 Dec;75(12):967-73. [Content Brief]
