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RNA aptamer

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

15

Fluorescent Dye

31

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-110251
    DFHBI-1T
    Maximum Cited Publications
    17 Publications Verification

    		 DNA Stain Others
    DFHBI-1T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells .
    DFHBI-1T
  • HY-D1373
    HBC
    3 Publications Verification

    HBC 530

    		 Fluorescent Dye Others
    HBC (HBC 530) is a GFP fluorophore-like synthetic dye, with a structurally rigid electron acceptor and a strong electron donor. HBC has a low fluorescence background, and when combined with Pepper (RNA aptamer), HBC forms a tight complex and activates and emits bright fluorescence (Kd of ~3.5 nM). HBC emission peaks vary in different complexes and covers the spectrum from cyan to red. HBC can be used in the live cell imaging of RNA (Em/Ex = 530/485 nm) .
    HBC
  • HY-136277
    DFHO
    1 Publications Verification

    		 Fluorescent Dye Others
    DFHO is a fluorogenic ligand of Corn fluorogenic aptamer. The RNA aptamer, Corn binds DFHO with a Kd value of 70 nM and converts it to a fluorescent form, enabling RNA imaging in cells .
    DFHO
  • HY-D2348A
    ACE TFA

    		Fluorescent Dye Infection
    ACE TFA is a low-background, photostable fluorophore with nanomolar binding affinity for the Okra RNA aptamer. ACE TFA enables clear visualization of mRNA in live bacteria and mammalian cells, including tracking the trafficking of mRNA to stress granules and dual-color super-resolution imaging of RNA in live cells. (Ex=488 nm, Em=555 nm) .
    ACE TFA
  • HY-153845
    RNA Aptamer Broccoli sodium

    		Biochemical Assay Reagents Others
    RNA Aptamer Broccoli sodium is a 49-nucleotide nucleic acid aptamer that is much shorter than Spinach and Spinach2. It exhibits bright green fluorescence when binding to DFHBI or DFHBI-1T (a soluble analog of the green fluorescent protein label). RNA Aptamer Broccoli sodium can be used for RNA expression or localization in living cells .
    RNA Aptamer Broccoli sodium
  • HY-148100
    Emapticap pegol
    1 Publications Verification

    NOX-E36

    		 CCR Inflammation/Immunology Cancer
    Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice .
    Emapticap pegol
  • HY-W073524
    DFAME

    		Fluorescent Dye Others
    DFAME is a red fluorophore (Ex = 508 nm, Em = 641 nm). DFAME binds to Beetroot and Corn (dimeric fluorescent RNA aptamers) to form Beetroot-DFAME (Kd = 460 nM) and Corn-DFAME (Kd = 3600 nM). Beetroot-DFAME and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research .
    DFAME
  • HY-D2348
    ACE

    		Fluorescent Dye Infection Others
    ACE is a low-background, photostable fluorophore with nanomolar binding affinity for the Okra RNA aptamer. ACE enables clear visualization of mRNA in live bacteria and mammalian cells, including tracking the trafficking of mRNA to stress granules and dual-color super-resolution imaging of RNA in live cells. (Ex=488 nm, Em=555 nm) .
    ACE
  • HY-153843
    RNA Aptamer Corn sodium

    		Biochemical Assay Reagents Others
    RNA Aptamer Corn (sodium) is a 28-nt-long aptamer that is substantially shorter than Spinach and Spinach2 and exhibits bright red fluorescence upon binding DFHO (a soluble analog of the intrinsic fluorophore of red fluorescent protein), RNA Aptamer Corn (sodium) can be used to visualize RNA expression or localization in live cells which have been soaked with chromophores. The Corn-DFHO does not become appreciably cytotoxic when illuminated. And most importantly, Corn-DFHO exhibits markedly increased photostability compared to other aptamer-chromophore complexes both in vitro and in vivo. (36 nt Corn construct: 5'-GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC-3'; A 36-nt RNA construct, comprised of the 28-nt minimal Corn sequence extended proximally with a 4 base-pair stem.)
    RNA Aptamer Corn sodium
  • HY-109561
    Pegaptanib sodium

    EYE001; NX1838

    		 VEGFR Metabolic Disease Inflammation/Immunology
    Pegaptanib sodium is an RNA aptamer with polyethylene glycol modifications, which is directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .
    Pegaptanib sodium
  • HY-DY1047
    DFHBI-1T (solution)

    		DNA Stain Others
    DFHBI-1T (solution) is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells .
    Solvent and concentration: DMSO: 20 mM
    DFHBI-1T (solution)
  • HY-110251A
    DFHBI-2T

    		DNA Stain Others
    DFHBI-2T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=500 nm/523 nm). DFHBI-2T is used to image RNA in live cells .
    DFHBI-2T
  • HY-175397
    Dth

    DFHBI-thalidomide

    		 PROTACs NF-κB Early 2 Factor (E2F) Bcl-2 Family VEGFR Cancer
    Dth (DFHBI-thalidomide) is an RNA aptamer-based PROTAC degrader. Dth can degrade a variety of endogenous proteins (such as mCherry, p50, p65 and E2F1) by replacing the 3′ module on the RNA scaffold with the RNA aptamer corresponding to the target protein. Dth upregulates IκB-α and Bax, and downregulates Bcl-2 and VEGF. Dth generates green fluorescence upon binding to the Broccoli RNA aptamer, enabling the tracing of RNA scaffolds. Dth can be used in cancer-related research .
    Dth
  • HY-160053
    Gint4.T aptamer sodium

    		PDGFR Cancer
    Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .
    Gint4.T aptamer sodium
  • HY-D2417
    SiRA 2

    		Fluorescent Dye Others
    SiRA 2 is a fluorescent inducer with a Kd value of 430 nM for binding to the SiRA RNA aptamer. When used in combination with the SiRA aptamer, SiRA 2 enables live-cell RNA imaging of aptamer-labeled mRNA as well as stimulated emission depletion super-resolution microscopy imaging. SiRA 2 has high photostability and forms a bright far-red light-up aptamer system upon binding to SiRA .
    SiRA 2
  • HY-153847
    RNA Aptamer Mango ΙΙ sodium

    		Biochemical Assay Reagents Others
    RNA Aptamer Mango Ⅱ (sodium) has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore), and can be used to visualize RNA expression or localization in live cells. Compared to the original Mango I aptamer, RNA Aptamer Mango Ⅱ (sodium) has markedly improved fluorescent properties, binding affinities, and salt dependencies.
    RNA Aptamer Mango ΙΙ sodium
  • HY-148100A
    Emapticap pegol sodium
    1 Publications Verification

    NOX-E36 sodium

    		 CCR Cancer
    Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .
    Emapticap pegol sodium
  • HY-161159
    DMHBO+
    1 Publications Verification

    		 Fluorescent Dye Others
    DMHBO+ is a cationic chromophore that binds to the Chili aptamer with a Kd of 12 nM. The Chili-DMHBO+ complex is an ideal fluorescence donor for FRET to the rhodamine dye Atto 590, suitable for imaging RNA in cells. Ex/Em=456/592 nm .
    DMHBO+
  • HY-177808
    A9g sodium

    A9g aptamer sodium

    		 PSMA Cancer
    A9g sodium is an RNA aptamer that inhibits the enzymatic activity of prostate-specific membrane antigen (PSMA).
    A9g sodium
  • HY-177817
    CL9 sodium

    		RIG-I-like receptor (RLR) Infection
    CL9 sodium, a RIG-I-specific RNA aptamer, activates signaling pathways for IFNβ produciton and efficiently blocks viral replication. RIG-I is a cytosolic receptor for non-self RNA that mediates immune responses against viral infections through IFNα/β prod
    CL9 sodium
  • HY-153835
    Pegnivacogin

    		Factor Xa Others
    Pegnivacogin is a novel RNA-aptamer based factor IXa inhibitor featuring a reversal agent, anivamersen.
    Pegnivacogin
  • HY-176801
    Oxide-DFHBI-demethyl

    		Ligands for Target Protein for PROTAC Cancer
    Oxide-DFHBI-demethyl is a target aptamer ligand (Ligand for Target Protein for PROTAC). Oxide-DFHBI-demethyl can be used for synthesis of RNA aptamer-based PROTAC Dth (HY-175397) .
    Oxide-DFHBI-demethyl
  • HY-153851
    RNA Aptamer Peach Ⅱ sodium

    		DNA Alkylator/Crosslinker Others
    RNA Aptamer Peach Ⅱ (sodium) has an exceptionally high affinity to TO3-Biotin (TO3-B, red channel, ex: 637 nm, em: 658 nm), and can be used to visualize RNA expression or localization in live cells.
    RNA Aptamer Peach Ⅱ sodium
  • HY-D1409
    DMTr-4'-F-U-CED-TBDMS phosphoramidite

    DMTr-4'-F-uridine-CED-TBDMS phosphoramidite

    		 DNA Stain Phosphoramidites Cardiovascular Disease
    DMTr-4'-F-U-CED-TBDMS phosphoramidite (DMTr-4'-F-uridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-F-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .
    DMTr-4'-F-U-CED-TBDMS phosphoramidite
  • HY-176802
    Oxide-DFHBI-demethyl-C6-NH2

    		Target Protein Ligand-Linker Conjugates Cancer
    Oxide-DFHBI-demethyl-C6-NH2 is a Target Protein Ligand-Linker Conjugate that incorporates a target aptamer ligand (HY-176801) and a PROTAC linker (HY-79577), which recruits E3 ligases. Oxide-DFHBI-demethyl-C6-NH2 can be used for synthesis of RNA aptamer-based PROTAC Dth (HY-175397) .
    Oxide-DFHBI-demethyl-C6-NH2
  • HY-153845B
    RNA Aptamer Broccoli sodium scrambled negative control

    		Biochemical Assay Reagents Others
    RNA Aptamer Broccoli sodium scrambled negative control is the sequence scrambled negative control of RNA Aptamer Broccoli sodium.
    RNA Aptamer Broccoli sodium scrambled negative control
  • HY-153843A
    RNA Aptamer Corn sodium scrambled negative control

    		Biochemical Assay Reagents Others
    RNA Aptamer Corn sodium scrambled negative control is the sequence scrambled negative control of RNA Aptamer Corn sodium.
    RNA Aptamer Corn sodium scrambled negative control
  • HY-153836
    Anivamersen

    		Factor Xa Others
    Anivamersen is an RNA aptamer to reverse the anticoagulant effect of the parenteral factor IXa inhibitor pegnivacogin. REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a complementary sequence reversal oligonucleotide.
    Anivamersen
  • HY-153836A
    Anivamersen sodium

    		Factor Xa Others
    Anivamersen sodium is an RNA aptamer to reverse the anticoagulant effect of the parenteral factor IXa inhibitor pegnivacogin. REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a complementary sequence reversal oligonucleotide.
    Anivamersen sodium
  • HY-153835A
    Pegnivacogin sodium

    		Factor Xa Others
    Pegnivacogin sodium is a novel RNA-aptamer based factor IXa inhibitor featuring a reversal agent, anivamersen.
    Pegnivacogin sodium
  • HY-160061
    P12FR2 aptamer sodium

    		Biochemical Assay Reagents Cancer
    P12FR2 aptamer sodium is a 2'-fluoropyrimidine-modified RNA aptamer targeting human PAUF with an estimated apparent KD of 77 nM. P12FR2 aptamer sodium inhibits PAUF-induced migration of PANC-1 (human pancreatic cancer cells) in wound healing assays and suppresses tumor growth in a mouse CFPAC-1 pancreatic cancer model .
    P12FR2 aptamer sodium
  • HY-177813
    148.1-38m sodium

    		HIV Infection
    148.1-38m sodium, an RNA aptamer, inhibits HIV-1 reverse transcriptase (RT) and interfere with viral replication.
    148.1-38m sodium
  • HY-D1408
    DMTr-4'-Me-U-CED-TBDMS phosphoramidite

    DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite

    		 DNA Stain Phosphoramidites Cardiovascular Disease
    DMTr-4'-Me-U-CED-TBDMS phosphoramidite (DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-Me-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .
    DMTr-4'-Me-U-CED-TBDMS phosphoramidite
  • HY-177815
    R-1 sodium

    		Influenza Virus Infection
    R-1 sodium is a RNA aptamer that bind to Non-structural protein 1 (NS1) (Kd = 1.62 ± 0.30 nM). R-1 sodium inhibits the interaction of NS1 with tripartite motif-containing protein 25 (TRIM25), and suppression of NS1 enabled retinoic acid inducible gene I (
    R-1 sodium
  • HY-177816
    R-2 sodium

    		Influenza Virus Infection
    R-2 sodium is a RNA aptamer that bind to Non-structural protein 1 (NS1) (Kd = 1.92 ± 0.27 nM). R-2 sodium inhibits the interaction of NS1 with tripartite motif-containing protein 25 (TRIM25), and suppression of NS1 enabled retinoic acid inducible gene I (
    R-2 sodium
  • HY-D3387
    TBI

    		Fluorescent Dye Others
    TBI is a fluorescence enhancer with a Kd of 71 nM for the Broccoli fluorogenic RNA aptamer. TBI binds to the Broccoli fluorogenic RNA aptamer to activate its fluorescence.TBI undergoes photobleaching of its trans form, which dissociates rapidly, while cis-TBI from the media replaces the dissociated fluorophore to enable fluorophore recycling.TBI enables enhanced fluorescence of Broccoli during continuous cellular imaging (Ex/Em = 485/527 nm) .
    TBI
  • HY-D3416
    TMR-DN

    TAMRA-2,4-dinitroaniline

    		 Fluorescent Dye Others
    TMR-DN (TAMRA-2,4-dinitroaniline) is a bright orange fluorescent probe that binds to the SRB-2 aptamer, with a Kd value of 35 nM for the SRB-2 aptamer. TMR-DN exhibits low background fluorescence, enabling wash-free live-cell RNA imaging .
    TMR-DN
  • HY-D3388
    BI dihydrochloride

    		Fluorescent Dye Drug Derivative Others
    BI dihydrochloride is a DFHBI (HY-110250) derivative for imaging of RNA in cells. BI dihydrochloride increases brightness and photostability of Broccoli aptamers in cells. BI dihydrochloride enables imaging of single Broccoli-tagged mRNAs in living cells. BI dihydrochloride exhibits peak excitation of 470 nm and peak fluorescence emission of 505 nm when bound to Broccoli.
    BI dihydrochloride
  • HY-D2282
    DFHBI-BI

    		Fluorescent Dye Others
    DFHBI-BI is a mimic of the green fluorescence protein chromophore. DFHBI-BI can be bound and activated by Broccoli ( a fluorogenic RNA aptamer) with higher affinity. DFHBI-BI prevents thermal unfolding of Broccoli at 37°C in mammalian cells, subsequently forming more fluorescent Broccoli-BI complexes. The fluorescence wavelength is 559/635 nm .
    DFHBI-BI
  • HY-177933
    mNOX-E36

    		CCR Neurological Disease Inflammation/Immunology
    mNOX-E36 is a murine-specific analogue of NOX-E36 (HY-148100), an anti-CCL-2 L-RNA aptamer that binds and neutralises the mouse chemokine CCL-2. mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery (GFS). mNOX-E36 ameliorates lupus nephritis in mice. mNOX-E36 can be used for GFS and lupus nephritis research .
    mNOX-E36

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