1420815-34-4
1420815-34-4
Chemical Structure
DFHO
- CAS No.: 1420815-34-4
- Formula:C12H9F2N3O3
- Molecular Weight:281.21
IUPAC Name: (E)-4-((E)-3,5-difluoro-4-hydroxybenzylidene)-1-methyl-5-oxo-4,5-dihydro-1H-imidazole-2-carbaldehyde oxime
InChIKey: MZFHSQVSFUWKDU-JDCBMBFUSA-N
SMILES: O=C(N1C)/C(N=C1/C=N/O)=C\C(C=C2F)=CC(F)=C2O
Biological Activity: DFHO is a fluorogenic ligand of Corn fluorogenic aptamer. The RNA aptamer, Corn binds DFHO with a Kd value of 70 nM and converts it to a fluorescent form, enabling RNA imaging in cells[1][2].
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DFHO | 99.68% | DFHO is a fluorogenic ligand of Corn fluorogenic aptamer. The RNA aptamer, Corn binds DFHO with a Kd value of 70 nM and converts it to a fluorescent form, enabling RNA imaging in cells. | ||||||||||||||||||||
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References
- [1]. Wenjiao Song, et al. Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex. Nat Chem Biol. 2017 Nov;13(11):1187-1194. [Content Brief]
- [2]. Hyaeyeong Kim, et al. A Fluorogenic RNA-Based Sensor Activated by Metabolite-Induced RNA Dimerization. Cell Chem Biol. 2019 Dec 19;26(12):1725-1731.e6. [Content Brief]
